Search Results for "Notch Signaling And Nociception"
Original Source: Monoamines activate neuropeptide signaling cascades to modulate nociception in C. elegans: a useful model for the modulation of chronic pain?
Monoamines and neuropeptides interact to modulate key behaviors in most organisms. This review is focused on the interaction between octopamine (OA) and an array of neuropeptides in the inhibition of a simple, sensory-mediated aversive behavior in the C. elegans model system and describes the role of monoamines in the activation of global peptidergic signaling cascades. OA has been often considered the invertebrate counterpart of norepinephrine, and the review also highlights the similarities between OA inh...
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The Notch signaling pathway has been found to play central roles in humans in stem cell maintenance, cell fate decisions, and in cancer as well. Notch family members are being revealed as oncogenes...
Cleft means 'split' or 'separation', and in Cleft Palate and Lip, the palate and lip are split respectively. This occurs as a congenital abnormality because during development in the...
phosphatidylinositol 3 kinase PI3K AKT mTOR Inhibitors
The phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in the regulation of cellular growth, survival, and proliferation. Dysregula...
Multiple sclerosis (MS) is the most common disabling neurological condition affecting 100,000 young adults in the UK. The condition results from autoimmune damage to myelin, causing interference i...
The proteasome is involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune respon...
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Notch Signaling and Kaposi's Sarcoma-Associated Herpesvirus
This detailed review describes the interplay of human tumor viruses with the Notch signaling pathway, with a special focus on Kaposi's sarcoma herpesvirus. Future Microbiology
Inhibition of the Notch Signaling Pathway Blocks Lung Cancer Growth in Mouse Model
Spanish researchers have shown that gamma-secretase inhibitors, which block the Notch signaling pathway, effectively stopped the growth of...
Notch signaling is known to modulate macrophage polarization. Hu and colleagues show that the Notch–RBP-J axis controls the expression of M1 macrophage–specific genes by promoting translation of t...
UCLA researchers report for the first time how cells communicate to activate Notch signaling
During formation of multi-cellular organisms, cells need to talk to each other to make critical decisions as to what kind of cell to become, as well as when and where to become that cell type. The Not...
How cells communicate to activate notch signaling
Researchers have shown for the first time that the mechanical force produced by cell-cell interactions is critical for programming by the Notch signaling system.
BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
The authors show that the oncogene Bcl6 is necessary for proper cortical neurogenesis in vivo and from embryonic stem cells. BCL6 alters the composition of Notch-dependent transcriptional complexes at...
We need to talk: How cells communicate to activate notch
(University of California - Los Angeles Health Sciences) researchers from UCLA's Jonsson Comprehensive Cancer Center have shown for the first time that the mechanical force produced by cell-cell inter...
Matching PubMed Articles
Hypoxia-induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling.
Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells d...
Notch signaling does not regulate segmentation in the honeybee, Apis mellifera.
Notch signaling has been implicated in the segmentation of vertebrates but is not involved in segmentation in Drosophila. Recent evidence, however, implies that Notch signaling regulates segmentation...
Notch Signaling and Bone Remodeling.
Notch signaling plays context-dependent roles in the development and maintenance of many cell types and tissues in mammals. In the skeleton, both osteoblasts and osteoclasts require Notch signaling fo...
Rabconnectin-3 is a functional regulator of mammalian Notch signaling.
The Notch signaling pathway is important for cell fate decisions in embryonic development and adult life. Defining the functional importance of the Notch pathway in these contexts requires the elucida...
Taking HSCs Down a Notch in Leukemia.
The Notch signaling pathway is activated in the majority of T cell acute lymphoblastic leukemias (T-ALL). Adding to the complexity of Notch signaling in hematopoiesis, recently in Nature, Klinakis et...
