Sickle Cell Disease

Oxidative damage

Stress

Stress is caused by your perception of situations around you and then the reaction of your body to them. The automatic stress response to unexpected events is known as 'fight or flight'. Dis...

Stress Disorders

Stress echocardiography

Role Of Oxidative Stress Needs To Be Re-Evaluated

Oxidative stress is believed to cause a number of diseases. Up to now, it has been common practice to measure oxidative stress levels by determining the oxidation state of a small molecule called glut...

Role of oxidative stress in diseases needs to be re-evaluated: Preventive detention for oxidizing agents

Oxidative stress is believed to cause a number of diseases. Up to now, it has been common practice to measure oxidative stress levels by determining the oxidation state of a small molecule called glut...

Preventive detention for oxidizing agents

(Helmholtz Association of German Research Centres) Oxidative stress is believed to cause a number of diseases. Up to now, it has been common practice to measure oxidative stress levels by determining...

Sickle cell disease, sickle cell trait are not the same

(HealthDay)—Both sickle cell disease and the condition known as sickle cell trait are genetic blood diseases: You're born with one or the other because of the genes inherited from your parents. Beyo...

Oxidative stress and the ageing endocrine system

A progressive decline in cellular function and organismal fitness and an increase in age-related diseases are associated with ageing; many theories have attempted to explain this phenomenon. This Revi...

Red hair is a sign of oxidative stress in wild boars, but gray is a-ok

(University of Chicago Press Journals) A coat of a certain color could be costly for wild boars, according to research published in the journal Physiological and Biochemical Zoology. The research foun...

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

Yuji Okuno et al. find that pathological angiogenesis in mice requires dampening of oxidative stress. In the absence of the ATM protein kinase, increased oxidative stress leads to activation of the p3...

Treatment relieves oxidative stress in periodontitis

Nonsurgical periodontal therapy significantly reduces oxidative stress in individuals with chronic periodontitis, research shows.

N-acetylcysteine reduces oxidative stress in sickle cell patients.

Oxidative stress is of importance in the pathophysiology of sickle cell disease (SCD). In this open label randomized pilot study the effects of oral N-acetylcysteine (NAC) on phosphatidylserine (PS) e...

MicroRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease.

Although individuals with homozygous sickle cell disease (HbSS) share the same genetic mutation, the severity and manifestations of this disease are extremely heterogeneous. We have previously shown t...

Reproductive Decisions in People With Sickle Cell Disease or Sickle Cell Trait.

In the context of an inherited condition such as sickle cell disease (SCD), it is critical to understand how people with SCD or carriers (sickle cell trait [SCT]) face the challenges of making informe...

Sickle cell disease serum induces NADPH enzyme subunit expression and oxidant production in leukocytes.

Oxidative stress plays a significant role in sickle cell disease (SCD), contributing to haemolysis, vaso-occlusive processes and endothelial dysfunction. To study the effects that the serum of SCD ind...

Plasma levels of advanced glycation end products are associated with haemolysis-related organ complications in sickle cell patients.

Summary Oxidative stress plays an important role in the pathophysiology of sickle cell disease (SCD). Plasma levels of advanced glycation end products (AGEs) are increased under oxidative conditions a...