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Search Results for "Paediatric Study Teriflunomide"

08:42 EDT 23rd April 2014 | BioPortfolio

Original Source: Phase III Study With Teriflunomide Versus Placebo in Patients With First Clinical Symptom of Multiple Sclerosis

The primary objective is to demonstrate that early intervention with Teriflunomide in patients presenting with their first clinical episode consistent with MS prevents or delays conversion to clinically definite Multiple Sclerosis [MS]. The secondary objectives are: - to demonstrate that Teriflunomide prevents or delays conversion to MS based on the revised McDonald Criteria and delays disability progression, - to evaluate the long-term safety of Teriflunom...

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KIACTA™ (also known as eprodisate) is an orally bioavailable small molecule intended for the treatment of AA amyloidosis, an orphan indication that results from long-standing inflammatory cond...


A virus is a small infectious agent that can replicate only inside the living cells of organisms. Virus particles (known as virions) consist of two or three parts: the genetic material made from eit...

Testicular Cancer

Testicular cancer represents only 1 per cent of all cancers in men, but it is the single biggest cause of cancer-related deaths in men aged 15-35 years in the UK. The causes of testicular cancer and...

Hepatitis C

Most hepatitis C virus (HCV) infected individuals seeking treatment are chronically infected. Treatment goal is to achieve a sustained virological response (SVR), which is the absence of serum HCV R...

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IQWiG study finds no added benefit of teriflunomide

Teriflunomide (trade name: Aubagio) has been approved in Germany since August 2013 for adults with relapsing remitting multiple sclerosis. In an early benefit assessment pursuant to the Act on the Ref...

[Articles] Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial

Teriflunomide 14 mg was associated with a lower relapse rate and less disability accumulation compared with placebo, with a similar safety and tolerability profile to that reported in previous studies...

Young clinicians prove susceptible to paediatric trauma distress

A study has found that medical staff regularly exposed to paediatric medical trauma experience more symptoms of secondary traumatic stress than their counterparts, and that the problem is most acute f...

The AAPS Journal: Changes in Individual Drug-Independent System Parameters during Virtual Paediatric Pharmacokinetic Trials: Introducing Time-Varying Physiology into a Paediatric PBPK Model

Type: Original PaperAlthough both POPPK and physiologically based pharmacokinetic (PBPK) models can account for age and other covariates within a paediatric population, they generally do not account f...

Compounding paediatric medicines from adult preparations may result in poor content uniformity

More standardised methods are needed for the extemporaneous preparation of paediatric medicines,according to a doctoral dissertation examined at the University of Eastern Finland. Hospital pharmacies...

Aubagio (Teriflunomide) for the Treatment of Multiple Sclerosis

Aubagio (teriflunomide) is an immunomodulatory agent indicated for the treatment of relapsing forms of multiple sclerosis (MS). It was developed by Genzyme.

Ethics experts study the transition from paediatric to adult health care services

In a study published by the medical journal Paediatrics & Child Health, IRCM researchers address shortcomings in transitional care in the Canadian healthcare system. The team led by Eric Racine and Em...

Mid Staffs set to retain key maternity and paediatric services

Key maternity and paediatric services look set to stay at Stafford Hospital following a high-profile public campaign, according to a final report on its future.

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Continuing education case study quiz.

Goal- The goal of this program is to educate pharmacists about the use of teriflunomide for the treatment of multiple sclerosis (MS). Objectives- At the completion of this program, the reader will be...

Teriflunomide and Its Mechanism of Action in Multiple Sclerosis.

Treatment of multiple sclerosis (MS) is challenging: disease-modifying treatments (DMTs) must both limit unwanted immune responses associated with disease initiation and propagation (as T and B lympho...

What does general paediatric surgery involve? An audit of paediatric cases in 1 year.

As all tertiary paediatric hospitals are based in the capital of Dublin, it is therefore necessary for general surgeons in centres outside of Dublin to undertake routine elective and emergency paediat...

Paediatric day case tonsillectomy: a safe, feasible and an economical way to treat patients - Yorkhill experience.

Day case surgery is widely encouraged as it has many benefits. In this study, we evaluate the feasibility of paediatric tonsillectomies as day case surgery procedures in a tertiary paediatric centre.

The impact of legislation on drug substances used off-label in paediatric wards-a nationwide study.

This nationwide study is aimed at describing to what extent the European Paediatric Regulation has met therapeutic needs in children.

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