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Search Results for "Paediatric Study Teriflunomide"

15:20 EDT 27th May 2017 | BioPortfolio

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SERAPHIN study

SERAPHIN - STUDY WITH ENDOTHELIN RECEPTOR ANTAGONIST IN PULMONARY ARTERIAL HYPERTENSION TO IMPROVE CLINICAL OUTCOME. SERAPHIN (Study with an Endothelin Rece...

KIACTA

KIACTA™ (also known as eprodisate) is an orally bioavailable small molecule intended for the treatment of AA amyloidosis, an orphan indication that results from long-standing inflammatory cond...

Viruses

A virus is a small infectious agent that can replicate only inside the living cells of organisms. Virus particles (known as virions) consist of two or three parts: the genetic material made from eit...

Hepatitis C

Most hepatitis C virus (HCV) infected individuals seeking treatment are chronically infected. Treatment goal is to achieve a sustained virological response (SVR), which is the absence of serum HCV R...

Spirometry Test

The gold standard in lung testing In the same way that blood pressure measurements provide a simple yet effective screening method for cardiovascular disease, spirometry tests can help to unmask t...

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Paediatric rheumatic diseases: Navigating the transition from paediatric to adult care

New guidelines from EULAR and the Paediatric Rheumatology European Society recommend a set of quality standards for the care of young adults with childhood-onset rheumatic diseases during their transf...

CD47 antibody fights paediatric brain tumors in preclinical testing

Five types of paediatric brain cancer were safely and effectively treated in mice by an antibody that causes immune cells to engulf and eat tumours without hurting healthy brain cells, according to a ...

New treatment recommendations for a high-risk paediatric leukaemia

Research led by St. Jude Children's Research Hospital has identified three genetic alterations to help identify high-risk paediatric patients with acute megakaryoblastic leukaemia (AMKL) who may benef...

Advances in paediatric ALL

Dr Locatelli speaks with ecancer about the state of care for paediatric ALL. He considers the past, present and future of treatment modalities, with the advent of TKI therapy for a range of patient s...

Molecular 'on switch' could point to treatments for paediatric brain tumour

Massachusetts General Hospital (MGH) researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common...

The importance of early collaboration in developing paediatric cancer medicines

Yesterday’s European Parliament event delivered a clear message: collaboration between all stakeholders is the only way to ensure an effective development of new drugs for paediatric cancers. The S...

US FDA grants paediatric exclusivity for AstraZeneca's Symbicort

The US Food and Drug Administration (FDA) granted six months of paediatric exclusivity for AstraZeneca's Symbicort (budesonide/formoterol) inhalation Aerosol.

BRIEF-Vectura says U.S. FDA approves IND for paediatric asthma trial

* Fda approves IND to support Vectura's wholly-owned programme VR647 in paediatric asthma Source text for Eikon: Further company coverage: (Bengaluru Newsroom: +91 80 6749 1136)

Matching PubMed Articles

Intracellular CD3+ T-lymphocyte teriflunomide concentration is poorly correlated with and has greater variability than unbound plasma teriflunomide concentration.

Leflunomide's active metabolite teriflunomide inhibits dihydro-oroate dehydrogenase (DHODH), an enzyme essential to proliferation of T-lymphocytes. As teriflunomide must reach the target site to have ...

The efficacy of teriflunomide in patients who received prior disease-modifying treatments: Subgroup analyses of the teriflunomide phase 3 TEMSO and TOWER studies.

Teriflunomide is a once-daily oral immunomodulator approved for relapsing-remitting multiple sclerosis (MS). The objective of this post hoc analysis of the phase 3, pooled TEMSO (NCT00134563) and TOWE...

Influence of postcode on paediatric admissions in Seville.

The postcode (where the home is situated) is an indicator of socioeconomic status and is associated with morbidity, mortality, and the use of health services. The aim of this study was to analyse its ...

Epidemiological study of paediatric germ cell tumours revealed the incidence and distribution that was expected, but a low mortality rate.

Germ cell tumours (GCTs) are a rare heterogeneous tumour group derived from primordial germ cells, which can be benign or malignant and occur in the gonads or extragonadally. This study mapped the pae...

Challenges of paediatric organ donation.

Paediatric organ donation represents a small fraction of overall organ donation in Australia and New Zealand and indeed world-wide. Many factors contribute to low donation rates including low paediatr...

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