Neutrophil elastase NE

Neutrophil elastase (NE) is a serine protease, expressed mainly by neutrophils, that is capable of degrading a variety of structural proteins of the extracellular matrix. Infiltration of activated n...

Pancreatic Enzymes

Pancreatic Endocrine Tumors

Pancreatic Islet Cell Transplantation

Pancreatic Cancer

The pancreas secretes a number of important hormones into the digestive tract and the blood stream. Cancers are most commonly exocrine than endocrine (neuroendocrine) tumors. Functional tumors secre...

Proteon plans Ph III for elastase in kidney disease surgery

Proteon Therapeutics is planning to move its recombinant human elastase into Phase III trials after announcing positive results from a Phase II trial of the product, PRT-201, in chronic kidney disease...

Imbalance between neutrophil elastase and α1-antitrypsin leads to obesity, inflammation

Many recent studies have suggested that obesity is associated with chronic inflammation in fat tissues. Researchers at Sanford-Burnham Medical Research Institute have discovered that an imbalance betw...

Brigham and Women's Researchers Find That Low Adiponcetin Is Associated With Increased Pancreatic Cancer Risk

Low prediagnostic levels of circulating adiponectin were associated with an increased risk of pancreatic cancer... Low adiponectin plasma levels are associated with the insulin resistance that manifes...

Oral bacteria may signal pancreatic cancer risk

(Brown University) Pancreatic cancer is highly lethal and difficult to detect early. In a new study, researchers report that people who had high levels of antibodies for an infectious oral bacterium t...

Sun exposure, vitamin D and pancreatic cancer risk

High levels of ultraviolet radiation at an individual's birth location, sun-sensitive skin type and a history of skin cancer each decreased risk for pancreatic cancer, according to study results prese...

Oral Bacteria Associated With Pancreatic Cancer Risk

Pancreatic cancer is highly lethal and difficult to detect early. In a new study, researchers report that people who had high levels of antibodies for an infectious oral bacterium turned out to have d...

Could Sunlight Lower Your Odds for Pancreatic Cancer?

TUESDAY, June 19 (HealthDay News) -- Adding to already-conflicting data about sun exposure, vitamin D levels and cancer risk, new Australian research suggests that experiencing high levels of ultravio...

Obesity Hormone Linked to Pancreatic Ca (CME/CE)

(MedPage Today) -- Low levels of the obesity-related hormone adiponectin are associated with an increased risk of pancreatic cancer, researchers reported.

Pancreatic insufficiency in patients with HIV infection: role of didanosine questioned.

OBJECTIVES: The aim of the study was to identify possible causes of pancreatic insufficiency in patients with HIV infection. METHODS: A retrospective analysis of 233 HIV-positive patients for whom fae...

Adaptive changes of pancreatic protease secretion to a short-term vegan diet: influence of reduced intake and modification of protein.

In our previous study, we demonstrated that abstaining from meat, for 1 month, by healthy omnivores (lacto-ovovegetarian model) resulted in a statistical decrease in pancreatic secretion as measured b...

Polymorphonuclear neutrophils promote dyshesion of tumor cells and elastase-mediated degradation of E-cadherin in pancreatic tumors.

Pancreatic ductal adenocarcinoma (PDAC) presenting with a micropapillary growth pattern is frequently associated with a prominent neutrophil infiltration into the tumor. The relevance of neutrophil in...

Acute mechanical effects of elastase on the infrarenal mouse aorta: Implications for models of aneurysms.

Intraluminal exposure of the infrarenal aorta to porcine pancreatic elastase represents one of the most commonly used experimental models of the development and progression of abdominal aortic aneurys...

Protein Matrices for Improved Wound Healing: Elastase Inhibition by a Synthetic Peptide Model.

The unique properties of silk fibroin were combined with keratin to develop new wound-dressing materials. Silk fibroin/keratin (SF/K) films were prepared to reduce high levels of elastase found on chr...