Search Results for "Pharmacokinetics Vitreous"
Original Source: Intraocular and Systemic Pharmacokinetics of Triamcinolone Acetonide after a Single 40-mg Posterior Subtenon Application.
PURPOSE: To characterize the pharmacokinetics of triamcinolone acetonide (TA) in aqueous, vitreous, and systemic circulation after a single subtenon injection. DESIGN: Prospective interventional case series. PARTICIPANTS: Thirty-six patients (36 eyes) who received a single posterior subtenon injection of TA (40 mg in 0.4 ml). METHODS: Aqueous, vitreous, and blood samples were obtained at 1-hour, 1-day, 3-day, 5-day, 10-day, 14-day, 21-day, and 28-day time points after the posterior subtenon TA injection. At...
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Macitentan (Opsumit®) is a novel dual endothelin receptor antagonist (ERA) that resulted from a tailored drug discovery process with the target to develop an ERA optimized for efficacy and safet...
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Ocriplasmin launched for vitreomacular traction
Patients with the eye condition vitreomacular traction can now be treated with a new medicine, ocriplasmin. It is available from Alcon Laboratories and marketed as Jetrea. Detachment of the vitreo...
Ranibizumab no better than saline for vitreous hemorrhage
(HealthDay)—For patients with vitreous hemorrhage from proliferative diabetic retinopathy (PDR), the probability of vitrectomy within 16 weeks after intravitreal injections of ranibizumab or saline...
Type: Original PaperPurposeTo determine the outward permeability of retina-choroid-sclera (RCS) layer for different ophthalmic drugs and to develop correlations between drug physicochemical properties...
Vitreous levels of somatostatin in patients with chronic uveitic macular oedema
Vitreous levels of somatostatin in patients with chronic uveitic macular oedema Eye advance online publication, August 10 2012. doi:10.1038/eye.2012.161 Authors: A Fonollosa, E Coronado, R...
[Clinical Picture] Sub-inner limiting membrane haemorrhages
In July, 2005, a 47-year-old man presented to us with impaired vision of his left eye. Fundoscopy examination showed premacular sub-inner limiting membrane haemorrhages () and a glistening light refle...
Vitreomacular traction syndrome: a comparison of treatment with intravitreal plasmin enzyme vs spontaneous vitreous separation without treatment Eye advance online publication, December 14 2012....
Evaluation of corpus geniculatum laterale and vitreous fluid by magnetic resonance spectroscopy in patients with glaucoma; a preliminary study Eye advance online publication, May 25, 2012. d...
Diagnostic cellular yield is superior with full pars plana vitrectomy compared with core vitreous biopsy Eye advance online publication, November 16 2012. doi:10.1038/eye.2012.224 Authors:...
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PURPOSE: To characterize the pharmacokinetics of triamcinolone acetonide (TA) in aqueous, vitreous, and systemic circulation after a single subtenon injection. DESIGN: Prospective interventional case...
Novel Vitreous Modulators for Pharmacologic Vitreolysis in the Treatment of Diabetic Retinopathy.
Vitreous constitutes about 80% of the volume of the human eye. It is an extended extracellular matrix that is composed of collagen, hyaluronan, and other extracellular matrix molecules, but mostly wat...
Ocular Pharmacokinetic Study Using T(1) Mapping and Gd-Chelate- Labeled Polymers.
PURPOSE: Recent advances in drug discovery have led to the development of a number of therapeutic macromolecules for treatment of posterior eye diseases. We aimed to investigate the clearance of macro...
Pharmacokinetics and pharmacodynamics of the sustained-release dexamethasone intravitreal implant.
PURPOSE. To determine the pharmacokinetics and pharmacodynamics of the sustained-release dexamethasone (DEX) intravitreal implant (Ozurdex; Allergan, Inc.). METHODS. Thirty-four male Macaca fascicular...
Purpose: To assess vitreous vascular endothelial growth factor (VEGF) concentrations in proliferative diabetic retinopathy (PDR) in comparison to proliferative vitreoretinopathy (PVR). Patients and Me...
