Search Results for "Poly Lactide Lactic Injection"
Original Source: A novel injectable in situ forming poly-DL-lactide and DL-lactide/glycolide implant containing lipospheres for controlled drug delivery.
One of the greatest challenges in in situ forming implant (ISFI) systems by polymer precipitation is the large burst release during the first 1-24 hours after implant injection. The aim of this study was to decrease the burst-release effect of a water-soluble model drug, donepezil HCl, with a molecular weight of 415.96 Da, from in situ forming implants using a novel in situ implant containing lipospheres (ISILs). In situ implant suspensions were prepared by dispersing cetyl alcohol and glyceryl stearate l...
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Intracytoplasmic sperm injection
poly adenyl ribose polymerase PARP Inhibitors
Poly (ADP-ribose) polymerases (PARPs) are a family of nuclear enzymes implicated in the regulation of multiple physiological cellular functions, including DNA repair, gene transcription, protein modif...
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Type: Original PaperThe influence of a tertiary amine, namely risperidone (pKa = 7.9) on the degradation of poly(d, l lactide-co-glycolide) (PLGA) microspheres was elucidated. Risperidone and blan...
Biodegradable coronary stents show long-term safety
NEW YORK (Reuters Health) - Follow-up for more than 10 years attests to the safety of the first-in-man fully biodegradable coronary stents made of poly-l-lactic acid (PLLA), Japanese and Dutch res...
Lactic Acidosis Secondary to Metformin Overdose
A 70-year-old man with type 2 diabetes presented to the ED with severe lactic acidosis after attempting suicide by metformin overdose. How should treatment be approached? Journal of Medical Case Rep...
Type: Original PaperPurposeTo utilize a novel type of polymer-drug conjugate micelle to enhance the delivery of low-potency curcumin.MethodsMultiple curcumin molecules were conjugated to poly(lactic a...
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding
Although the poly(A) tail and poly(A) binding protein (PABP) have emerged as important effectors of miRNA function, how they contribute to miRNA-mediated gene silencing has been unclear. A combination...
Type: Original PaperPurposeTo develop poly 1,3-bis-(p-carboxyphenoxy) hexane-co-sebacic acid (p(CPH/SA)) microspheres for controlled basal insulin delivery and evaluate their in vivo efficacy and toxi...
Toronto, Ontario (PRWEB) May 07, 2013 BroadConnect Telecom, North Americaâs premier supplier of hosted voice, video, managed data and security services has announced their intent to deliver un...
Type: Original PaperPurposeRecombinant osteoprotegerin (OPG) has been proven to be useful for treating various bone disorders such as osteoporosis. To improve its in vivo pharmacological effect, OPG w...
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The quality of the monomers lactic acid and lactide as well as the chemical changes induced during polymerization and processing are crucial parameters for controlling the properties of the resulting...
The simultaneous improvement of the melting temperature (T(m) = 224 °C) and the decomposition temperature (T(10) = 359 °C) of poly(lactide)s was achieved by the stereocomplex formation of poly(l-lac...
High-Pressure Reactivity of l,l-Lactide.
l,l-Lactide, a dimer of l-lactic acid, is the typical monomer used for the catalytic synthesis of poly(l-lactic acid) (PLLA). We studied its phase diagram and reactivity at high pressure and high temp...
Electrospinning is a long-known polymer processing technique that has received more interest and attention in recent years due to its versatility and potential use in the field of biomedical research....
To avoid the clinical inconvenience of repeated injection of the immune modulator thymopentin (TP5), biodegradable implants comprising a mixed polymer matrix of poly(lactide acid) (PLA) and poly(lacti...
