Drug Delivery - news, views, blogs

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals.  Drug delivery technologies are patent protected formulat...

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Pharmaceutical Research: Spray-Dried Chitosan Microparticles for Cellular Delivery of an Antigenic Protein: Physico-chemical Properties and Cellular Uptake by Dendritic Cells and Macrophages

Type: Original PaperPurposeSpray-dried chitosan microparticles for cellular delivery of antigen to dendritic cells (DC) and macrophages (Mϕ) were investigated.MethodsChitosan microparticles were prep...

Pharmaceutical Research: A Combinatorial Library of Bi-functional Polymeric Vectors for siRNA Delivery In Vitro

Type: Original PaperPurposeTo apply a combinatorial chemistry approach toward the design of polymeric vectors, and to evaluate their effectiveness as siRNA delivery systems in vitro.MethodsPoly(acryli...

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

The sustained release of both hydrophilic and hydrophobic immunomodulators for metastatic melanoma by nanoscale liposomal polymeric gels administered intratumorally or systemically is demonstrated. It...

Novel topical medication delivery technology aims to overcome problems of eyedropper administration

A microdroplet fluid ejection device is a promising new technology for topical delivery of ophthalmic medications.

When Breathing Is Impaired, Injecting Oxygen Microparticles Into A Vein Could Save Lives

Patients unable to breathe because of acute lung failure or an obstructed airway need another way to get oxygen to their blood - and fast - to avoid cardiac arrest and brain injury. A team led by rese...

Pharmaceutical Research: Critical Solvent Properties Affecting the Particle Formation Process and Characteristics of Celecoxib-Loaded PLGA Microparticles via Spray-Drying

Type: Original PaperPurposeIt is imperative to understand the particle formation mechanisms when designing advanced nano/microparticulate drug delivery systems. We investigated how the solvent power a...

Direct injection of oxygen microparticles could deliver oxygen when breathing is impaired

Patients unable to breathe because of acute lung failure or an obstructed airway need another way to get oxygen to their blood—right now—to avoid cardiac arrest and brain injury. A team led by res...

Pharmaceutical Research: Ternary Polymeric Nanoparticles for Oral siRNA Delivery

Type: Original PaperPurposePoor stability and inefficient absorption in the intestinal tract are major barriers confronting oral delivery of siRNA. We aimed to uncover if ternary polymeric nanoparticl...

A Biodegradable and Biocompatible Drug-Delivery System Based on Polyoxalate Microparticles.

Drug delivery using biodegradable polymeric microparticles is becoming an important means of delivering therapeutic agents. In this work, we describe polyoxalate microparticles as a biodegradable and...

Polymethacrylate Microparticles Gel for Topical Drug Delivery.

PURPOSE: Evaluating the potentials of particulate delivery systems in topical drug delivery. METHODS: Polymethacrylate microparticles (MPs) incorporating verapamil hydrochloride (VRP) as a model hydro...

Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model.

Inhaling corticosteroids, such as budesonide (BD), is the most common treatment for asthma. However, frequent steroid administration is associated with many side effects. We hypothesized that porous m...

Inhalable Microparticles as Carriers for Pulmonary Delivery of Thymopentin-Loaded Solid Lipid Nanoparticles.

PURPOSE: Microparticles containing solid lipid nanoparticles (SLNs) are receiving increased attention as carriers for the lung delivery of the SLNs. Thus, we aim to prepare the hybrid microparticles a...

Immunopotentiation of Hepatitis B Vaccine Using Biodegradable Polymers as an Adjuvant.

BACKGROUND/PURPOSE: The purpose of this research was to develop an alternative adjuvant for hepatitis B vaccine (HBsAg) that elicits a long-lasting immune response after a single administration. In th...