Primary PEU

Primary causes

Primary CDI

Primary Morphology

Primary Hemochromatosis

Population pharmacokinetics of clozapine and its primary metabolite norclozapine in Chinese patients with schizophrenia

Global Metabolite Profiling

This eBriefing focuses on emerging strategies for global metabolite profiling and how these technologies are being applied to the field of "functional genomics"—the ultimate goal being discovery...

Systematic identification of allosteric protein-metabolite interactions that control enzyme activity in vivo

Integrating metabolomics and computational modeling provides a method to identify allosteric enzyme-metabolite interactions, which have been inaccessible to systematic mapping.

Ion channels: Metabolite targets sodium channels in diabetic pain

Diabetic patients often experience chronic pain as a complication of their condition. In this study, a metabolite produced under hyperglycaemic conditions is shown to influence the function of voltage...

Insulin glargine's main metabolic effect as metabolite M1

(HealthDay)—For patients with type 2 diabetes, following administration of a subcutaneous injection of a therapeutic dose of insulin glargine, glargine is minimally detectable in blood, and most of...

Metabolite damage-control: How our cells cope with toxic small molecules

Scientists have reviewed an important, but so far neglected, part of metabolism, namely metabolite damage-control. Researchers now present a comprehensive overview of the known reactions generating un...

Gold biomineralization by a metallophore from a gold-associated microbe

Microorganisms produce and secrete secondary metabolites to assist in their survival. We report that the gold resident bacterium Delftia acidovorans produces a secondary metabolite that protects from...

Global Metabolomics (Biomarker Discovery/Metabolite Detection/Metabolite Profiling) - 2013 Market Report

Dublin, Ireland (PRWEB) March 15, 2013 Over the last decade, genomics and proteomics have been used as key tools to discover potential drug targets and to better understand the complexities of biol...

Drug Metabolite Profiling and Identification by High-resolution Mass Spectrometry.

Mass spectrometry plays a key role in drug metabolite identification, an integral part of drug discovery and development. The development of high-resolution (HR) MS instrumentation with improved accur...

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation.

Itaconic acid (ITA), or methylenesuccinic acid, is not generally classified as a mammalian metabolite. Using NMR-based metabolomics and (13)C-labeling, we have detected ITA in both macrophage-like VM-...

Heterogeneity in malignant gliomas: a magnetic resonance analysis of spatial distribution of metabolite changes and regional blood volume.

First-pass contrast-enhanced dynamic perfusion imaging provides information about the regional cerebral blood volume (rCBV), an increase of which indicates neovascularization. MR spectroscopic imaging...

Toxic Metabolite Formation from Troglitazone (TGZ): New Insights from a DFT Study.

The hepatotoxicity of Troglitazone (TGZ) has been ascribed to the formation of reactive metabolites, and the primary reactive metabolite of TGZ has been confirmed to be an o-quinone methide. Oxidation...

Potential of Thermophilic Fungus Rhizomucor pusillus NRRL 28626 in Biotransformation of Antihelmintic Drug Albendazole.

In the present investigation, thermophilic fungus Rhizomucor pusillus was used to study biotransformation of antihelmintic drug albendazole to produce its active metabolite, albendazole sulfoxide and...