Prion Diseases

Dementia

Dementia describes a range of symptoms of cognitive decline. For example memory loss, problems with reasoning and communication skills, and a reduction in a person's abilities and skills in carr...

Transdermal and Intravaginal Steroid Contraceptives

Delirium and Dementia

Frontotemporal Dementia

A microplate-based prion seeding assay is more sensitive and much faster than using animal models

Using a newly developed prion seeding assay researchers can now measure prion seeding...

Copper Facilitates Prion Disease

Scientists report that reducing copper in the body delays the onset of prion disease. Mice lacking a copper-transport gene lived significantly longer when infected with a prion disease than did normal...

Characterization of prion-like conformational changes of the neuronal isoform of Aplysia CPEB

The protein CPEB, required for learning-related synaptic plasticity in the snail Aplysia, has been suggested to convert from a soluble to a prion-like state. Now these conformational forms of Aplysia...

Reducing copper in the body delays onset of prion disease

Many of us are familiar with prion disease from its most startling and unusual incarnations-the outbreaks of "mad cow" disease (bovine spongiform encephalopathy) that created a crisis in the global be...

Scientists show copper facilitates prion disease

(Medical Xpress) -- Many of us are familiar with prion disease from its most startling and unusual incarnations—the outbreaks of “mad cow” disease (bovine spongiform encephalopathy) tha...

Role May Be Played By Prion Protein In Aiding Learning And Memory

Scientists from the University of Leeds have found that the protein called prion helps our brains to absorb zinc, which is believed to be crucial to our ability to learn and the wellbeing of our memor...

Prion protein hints at role in aiding learning and memory

Scientists from the University of Leeds have found that the protein called prion helps our brains to absorb zinc, which is believed to be crucial to our ability to learn and the wellbeing of our memor...

TSRI scientists identify new drugs for human prion disease

Human diseases caused by misfolded proteins known as prions are some of most rare yet terrifying on the planet—incurable with disturbing symptoms that include dementia, personality shifts, hallucina...

Progress in the development of therapeutic antibodies targeting prion proteins and beta-amyloid peptides.

Prion diseases and Alzheimer's disease (AD) are characterized by protein misfolding, and can lead to dementia. However, prion diseases are infectious and transmissible, while AD is not. The similariti...

Steroid-responsive encephalopathy subsequently associated with Alzheimer disease pathology: A case series.

Background: Steroid-responsive encephalopathies can be considered vasculitic or non-vasculitic. Clinicopathological studies of non-vasculitic steroid-responsive encephalopathy are unusual, but can exp...

Variably Protease-Sensitive Prionopathy: a Novel Disease of the Prion Protein.

Variably protease-sensitive prionopathy (VPSPr) is a novel disease involving the prion protein (PrP) that has clinical similarities with non-Alzheimer's dementias especially frontotemporal dementia, d...

Divergent clinical and neuropathological phenotype in a Gerstmann-Sträussler-Scheinker P102L family.

OBJECTIVES: Gerstmann-Sträussler-Scheinker syndrome belongs to the genetic prion diseases being associated with mutations in the prion protein gene (PRNP). The most common is the point mutation at co...

Detergents modify proteinase K resistance of PrP Sc in different transmissible spongiform encephalopathies (TSEs).

Prion diseases are diagnosed by the detection of their proteinase K-resistant prion protein fragment (PrP(Sc)). Various biochemical protocols use different detergents for the tissue preparation. We fo...