Search Results for "Proteinase Activated Receptor"
Original Source: Proteinase-activated receptors in the endometrium and endometriosis.
Proteinase-activated receptors (PARs) are G protein-coupled receptors activated by various proteinases. PARs play important roles in haemostasis, thrombosis, and inflammation. PAR1 and PAR2 are expressed in endometrial cells from the eutopic endometrium and endometriotic cells derived from endometriotic lesions. A typical activator of PAR1, thrombin, and a typical activator of PAR2, tryptase, are produced in the endometrium as well as endometriotic lesions. PAR1 activation in endometrial stromal cells induc...
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Peroxisome Proliferator Activated Receptor PPAR Agonists
Despite the tremendous attrition rate of PPAR agonist R&D over the last 20 years, the ones in the market are commercially quite successful and spur development of improved successors. The current...
Factor V Resistance to Activated Protein C APC
Metabotropic Glutamate Receptor 4 (mGluR4)
Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor famil...
Parathyroid Hormone PTH Receptor
There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins. * parathy...
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High-resolution crystal structure of human protease-activated receptor 1
The X-ray crystal structure of the human G-protein-coupled receptor protease-activated receptor 1 (PAR1) bound to the antagonist vorapaxar is solved, revealing an unusual method of drug binding that s...
Grifols to begin trial of inhaled alpha1-proteinase inhibitor for CF
Spanish firm Grifols has announced plans to begin a safety trial of a next-generation inhaled formulation of alpha1-proteinase inhibitor later this year. The news follows the decision by the US FDA to...
[Comment] Anti-interleukin-2 receptor alpha for multiple sclerosis?
In The Lancet, Ralf Gold and colleagues report the results of their 52-week, randomised, placebo-controlled, dose-ranging, phase 2 study of daclizumab high-yield process (HYP)—a humanised monoclonal...
Central centrifugal cicatricial alopecia pathogenesis studied
(HealthDay)—Protease-activated receptor 2 (PAR-2), which is activated by cowhage, may play a role in central centrifugal cicatricial alopecia (CCCA), the most common cause of scarring hair loss in A...
[Seminar] Androgen insensitivity syndrome
Androgen insensitivity syndrome in its complete form is a disorder of hormone resistance characterised by a female phenotype in an individual with an XY karyotype and testes producing age-appropriate...
Ubiquitin removal in the TGF-β pathway
The transforming growth factor (TGF-β) pathway is regulated by ubiquitin-mediated proteolysis at different levels. Two studies now identify deubiquitinating enzymes (DUBs) for the TGF-β type I recep...
Treatment with an Alpha-1 Proteinase Inhibitor Slows the Progression of Emphysema in Some Patients
ATS 2013, PHILADELPHIA─Treatment with an Alpha-1 proteinase inhibitor (A1-PI), a naturally occurring protein that protects lung tissue from breakdown and protects the lung's elasticity, is effective...
Brown Fat Activated By Cold, Not Ephedrine
Researchers at Joslin Diabetes Center have shown that while a type of "good" fat found in the body can be activated by cold temperatures, it is not able to be activated by the drug ephedrine. The find...
Matching PubMed Articles
AIMS: Proteinase-activated receptor-2 (PAR2) and transient receptor potential vanilloid-1 (TRPV1) are co-localized in the primary afferents, and the trans-activation of TRPV1 by PAR2 activation is inv...
Targeting proteinase-activated receptors: therapeutic potential and challenges.
Proteinase-activated receptors (PARs), a family of four seven-transmembrane G protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs are characterized by a uniqu...
We performed this study to determine if curcumin affects pro-inflammatory responses to activation of proteinase-activated receptor-2 (PAR2) in human pulmonary adenocarcinoma A549 cells. Curcumin compl...
Abstract We hypothesized that kallikrein-related peptidase 4 (KLK14) is produced by colonic tumours and can promote tumourigenesis by activating proteinase-activated receptors (PARs). We found that:...
Objective and Design: Although proteinase-activated receptor (PAR)-4 has been implicated in inflammation, its role in regulating eosinophil recruitment in response to chemoattractants has not yet been...
