Raf Kinases Pages on BioPortfolio:

BioPortfolio - PAK1 - p21/Cdc42/Rac1-activated kinase 1 (STE20 ...
Characterization of S338 phosphorylation for Raf-1 activation. Raf kinases are essential for regulating cell proliferation, survival and. ...
http://www.bioportfolio.com/gene/5058-PAK1.html...

Biotechnology News new drug class tesamorelin. serostim. vat ...
Companies to Study B-Raf Kinase Inhibitors for Cancer Treatments INDIANAPOLIS, Ind. and LAWRENCE, Kan., Oct. 3 /PRNewswire-FirstCall/ -- Eli Lilly and ...
http://www.bioportfolio.co.uk/cgi-bin/dialogserver.exe?CMD=e...

Biotechnology News kidney ckd. bp. flynn. peralta. shlipak ...
Potential $130M Per Program Privately held Deciphera Pharmaceuticals LLC signed its first big pharma deal, licensing rights to four preclinical B-Raf kinase ...
http://www.bioportfolio.co.uk/cgi-bin/dialogserver.exe?CMD=e...

BioPortfolio - PKM2 - pyruvate kinase, muscle
BIND, pyruvate kinase, muscle isoform 1 · v-raf-1 murine leukemia viral oncogene homolog 1, RAF1 (C-Raf) interacts with PKM2 (PyK). ...
http://www.bioportfolio.com/gene/5315-PKM2.html...

BioPortfolio - wikipedia p21RAS
BioPortfolio wikipedia p21RAS Oncogene Protein P21Ras Bioportfolio Indepth Wikipedia ... Sulindac block the interaction of p21ras with the Raf kinase thus
...
http://www.bioportfolio.com/search/wikipedia_p21RAS.html...

BioPortfolio RAF1 Antibody
Protein Kinases O-Z -- Search - Antibodies Abs to Cardiac Markers 14-3-3 Actin ... Primary Antibodies : Kinases and Phosphatases - Anti-Human Raf-1 pS239 ...
http://www.bioportfolio.co.uk/antibody/anti-RAF1.htm...

LeadDiscovery - Therapeutic Advances - Focus on Angiogenesis
Promising development of BAY 43-9006, a novel Raf Kinase and Vascular Endothelial Growth Factor Receptor Inhibitor, for the treatment of renal and
other ...
http://www.bioportfolio.com/LeadDiscovery/targetangiogenesis...

BioPortfolio anti-c antibody Antibody
... related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, .... Focus on - Antibodies to Rhodopsin and Rhodopsin Kinases - Acris
...
http://www.bioportfolio.co.uk/antibody/anti-anti-c%20antibod...

BioPortfolio - Immunotherapy patents
7423150, Substituted benzazoles and methods of their use as inhibitors of Raf kinase. 7423123, Interleukin-9 antagonist muteins and their pharmacological ...
http://www.bioportfolio.com/indepth/immunotherapy/patents.ht...

Biotechnology News agreement deciphera. raf. braf. kinas. lilli ...
Companies to Study B-Raf Kinase Inhibitors for Cancer Treatments INDIANAPOLIS, Ind. ... Eli Lillylicensed Deciphera Pharmaceuticals preclinical B-Raf kinase
...
http://www.bioportfolio.co.uk/cgi-bin/dialogserver.exe?CMD=e...

Results from other life science and pharmaceutical sites:

Raf kinase signaling functions in sensory neuron differentiation ...
Both kinase-dependent and kinase-independent Raf signaling have been ..... Our current results indicate that Raf kinases may mediate this effect of NT3 ...
http://www.nature.com/neuro/journal/v10/n5/full/nn1898.html...

Isotype-specific functions of Raf kinases. [Exp Cell Res. 1999 ...
However, it is not known how these isotype-specific functions of Raf kinases occur in the cell. Published data suggest that Raf proteins might differ in the
...
http://www.ncbi.nlm.nih.gov/pubmed/10579909...

Antitumor activity of a phosphorothioate antisense ...
Substantial evidence exists supporting a direct role for raf kinases in the development and maintenance of certain human malignancies. ...
http://www.nature.com/nm/journal/v2/n6/abs/nm0696-668.html...

Forebrain-specific knockout of B-raf kinase leads ...[J Neurosci ...
Raf kinases are downstream effectors of Ras and upstream activators of the MEK- ERK cascade. Ras and MEK-ERK signaling play roles in learning and memory ...
http://www.ncbi.nlm.nih.gov/pubmed/16342120...

B-Raf kinase inhibitors for cancer treatment Nanxin Li , David ...
inhibitors of B-Raf kinase are currently undergoing clinical ... homolog was called c-Raf-1. The Raf kinases play central. roles in cell proliferation and
...
http://www.biomedcentral.com/content/pdf/cd-799046.pdf...

The ins and outs of Raf kinases. [Trends Biochem Sci. 1994 ...
Raf kinases are signal-integrating enzymes that have the ability to switch tyrosine kinase signalling to serine/threonine phosphorylation and connect
growth ...
http://www.ncbi.nlm.nih.gov/pubmed/7855890...

Plasma Membrane-Targeted Raf Kinase Activates NF-κB and Human ...
In particular, the NF-κB motif in the HIV long terminal repeat (LTR) represents a Raf-responsive element in fibroblasts. Regulation of the Raf kinase in T ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=10...

Positive and negative regulation of Raf kinase activity and ...
Activating and inhibitory phosphorylation mechanisms play an essential role in regulating Raf kinase activity. Here we demonstrate that phosphorylation of ...
http://www.nature.com/emboj/journal/v20/n14/full/7593869a.ht...

Activation of B-Raf kinase requires phosphorylation of the ...
The Raf kinase family serves as a central intermediate to relay signals from Ras to ERK. The precise molecular mechanism for Raf activation is still not ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=31...

ArQule Announces the Discovery of Oral B-RAF Kinase Inhibitors for ...
RAF Kinase Inhibitors This newly announced program comprises a series of compounds which inhibit both B-RAF and c-RAF kinases in the nanomolar range. ...
http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=...

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