Cyclic Changes in Other Reproductive Organs

Electrophysiologic Studies EPS

Imaging studies

Electromyography and nerve conduction velocity studies

Metabotropic Glutamate Receptor 4 (mGluR4)

Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor famil...

[Articles] Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: final results of two randomised, placebo-controlled trials

Raltegravir has a favourable long-term efficacy and safety profile in integrase-inhibitor-naive patients with triple-class resistant HIV in whom antiretroviral therapy is failing. Raltegravir is an al...

Long-Term HIV Response Seen with Raltegravir (CME/CE)

(MedPage Today) -- WASHINGTON - At 5 years, more patients maintained better HIV suppression with raltegravir (Isentress) than with efavirenz (Sustiva) when each was combined with standard treatment, r...

Adherence to Raltegravir-Based Regimens Among HIV Patients

How do patterns of adherence to raltegravir influence the risk of virological failure in HIV positive patients? JAIDS: Journal of Acquired Immune Deficiency Syndromes

Enzyme that acts as innate immunity sensor

Two studies by researchers at UT Southwestern Medical Center could lead to new treatments for lupus and other autoimmune diseases and strengthen current therapies for viral, bacterial, and parasitic i...

Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein–protein interaction

Biofilm formation allows pathogenic bacteria to evade detection by the immune system. The second messenger cyclic di-GMP bridges protein subunits of the poly-GlcNAc synthesis machinery to stimulate sy...

[Articles] Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study

The non-inferior efficacy and similar safety profile of dolutegravir compared with raltegravir means that if approved, combination treatment with once-daily dolutegravir and fixed-dose nucleoside reve...

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

The crystal structures of human STING in the apo and c-di-GMP–bound states, supported by mutagenesis and biochemical data, reveal that c-di-GMP binds to preformed dimeric STING. c-di-GMP prolongs ST...

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

Activation of type I interferon by c-di-GMP and c-di-AMP depends on the adaptor STING. Cheng and colleagues show that these bacterial secondary messengers are detected by the helicase DDX41, which for...

Lack of a Clinically Meaningful Pharmacokinetic Effect of Rifabutin on Raltegravir: In Vitro/In Vivo Correlation.

Raltegravir is an HIV-1 integrase strand transfer inhibitor with potent activity against HIV-1. A prior investigation of raltegravir coadministered with rifampin demonstrated a decrease in plasma conc...

Simultaneous determination of raltegravir and raltegravir glucuronide in human plasma by liquid chromatography-tandem mass spectrometric method.

Raltegravir is a highly efficacious inhibitor of HIV integrase. Large pharmacokinetic variability has been reported in clinical trials and this could be due to glucuronidation of raltegravir, the only...

Phenotypic susceptibility of HIV-2 to raltegravir: integrase mutations Q148R and N155H confer raltegravir resistance.

OBJECTIVES:: Raltegravir is the first integrase strand transfer inhibitor approved for treating HIV-1 infection. Although emerging data suggest that raltegravir may also be useful for HIV-2 treatment,...

Raltegravir: a review of its pharmacokinetics, pharmacology and clinical studies.

Importance of the field: Raltegravir is the first HIV-integrase inhibitor licensed by the FDA. Areas covered in this review: A PubMed search was conducted for all published reports up to 1 May 2010 re...

Voltammetric assay of anti-anginal drug nicorandil in different solvents.

Voltammetric behaviour and assay of nicorandil were investigated using square-wave and cyclic voltammetry. Voltammograms in Britton-Robinson (BR) buffer exhibited one well-defined and two merged reduc...