Follicular phase

Atypical Moles

Ovarian Follicular Development

Drug Development for Rare Diseases

The economics of any industry relies on a large demand for a particular product; this applies to the pharmaceutical industry where efforts are focused on big and relatively straight-forward diseases...

Orphan Diseases

The European Organization for Rare Diseases considers orphan diseases to be those that are rare (occur in 1 in 1500 to 1 in 2500 patients, according to US Rare Disease Act 2002 and European Commissi...

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

Germinal centres support antibody affinity maturation and memory formation. Follicular T-helper cells promote proliferation and differentiation of antigen-specific B cells inside the follicle. A genet...

Origins of key immune cells discovered

Neuropathologists have solved the puzzle surrounding the origins of follicular dendritic cells – cells of lymphoid organs that play an important role in many autoimmune and infectious diseases. The...

Atypical E2Fs drive atypical cell cycles

It is well documented that polyploid cells exist in mammalian tissues such as the placenta and liver, but their function and the mechanisms for their formation have remained elusive. Two studies now i...

UZH research team discovers the origins of key immune cells

(University of Zurich) Neuropathologists at the University of Zurich have solved the puzzle surrounding the origins of follicular dendritic cells -- cells of lymphoid organs that play an important rol...

Inadequate T follicular cell help impairs B cell immunity during HIV infection

B cell responses are impaired in HIV-infected individuals. Elias Haddad and colleagues now report that follicular helper T (TFH) cells, which are crucial for the maturation of B cell memory and de...

Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress

The splenic marginal zone is a unique microenvironment where resident immune cells are exposed to the open blood circulation. Even though it has an important role in responses against blood-borne anti...

Rising incidence of atypical femoral fractures linked with bisphosphonate use

NEW YORK (Reuters Health) - Atypical femoral fractures associated with bisphosphonate use, although rare, have increased in incidence over the past 12 years, researchers from Switzerland reported...

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

Follicular regulatory T cells control humoral immune responses, but how these cells are in turn controlled has been unclear. Sharpe and colleagues demonstrate that signaling via PD-1 regulates number...

Atypical Burkitt's lymphoma transforming from follicular lymphoma.

ABSTRACT: Amongst follicular lymphoma that transforms into a high-grade lymphoma, majority are diffuse large B cell lymphoma. Here we reported a rare atypical Burkitt's lymphoma transformation from an...

Another look at follicular lymphoma: immunophenotypic and molecular analyses identify distinct follicular lymphoma subgroups.

AIMS: The aim of this study was to analyse the immunophenotypic and molecular features of a large series of follicular lymphomas, focusing in particular on atypical cases that fail to express CD10 and...

Nodal follicular lymphoma without complete follicular dendritic cell networks is related to localized clinical stage.

Follicular lymphoma is the most common low-grade lymphoma and it frequently presents with a systemic disease, often showing advanced clinical stage (III/IV). The lymphoma cells are usually growing ass...

Erratum: Should "atypical follicular cells" in thyroid fine-needle aspirates be subclassified?

The elusive identity of T follicular helper cells.

Follicular helper T (Tfh) cells provide help to B cells and allow formation of long-lived antibody responses. Despite an improved understanding of the molecular program that drives Tfh cell formation,...