Search Results for "Ras Pathway In Regeneration"
Original Source: Liver regeneration and tumour stimulation: implications of the renin-angiotensin system.
Abstract Liver resection is the most effective treatment for primary liver tumours and metastasis to the liver, and remains the only potentially long-term curative therapy for patients with colorectal cancer (CRC) liver metastases. Nevertheless, there is a significant incidence of tumour recurrence following liver resection. Cellular and molecular changes resulting from resection and the subsequent liver regeneration process may influence the kinetics of tumour growth, contributing to recurrence. Although c...
Matching Channels
EmbdenMeyerhof Pathway Defects
The Notch signaling pathway has been found to play central roles in humans in stem cell maintenance, cell fate decisions, and in cancer as well. Notch family members are being revealed as oncogenes...
Neurotrophic Growth Factors NGF BDNF CNTF
Early clinical trials with classical neurotrophic growth factor proteins such as NGF, BDNF, CNTF have failed for various reasons including safety, efficacy and convenience of administration as well as...
Despite the humorous name, hedgehog signalling cascades are central to embryonic development and has been implicated in the development of a number of diseases, including cancer. The downstream ca...
MAP kinase kinase MEK Inhibitors
The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death. The MAPK pathway has emerged as the crucial route between membrane-bound Ras...
Matching News
Neurosteroids as regenerative agents in the brain: therapeutic implications
The ageing brain retains the capacity for regeneration. This Review highlights the potential of the neurosteroid, allopregnanolone, as a regenerative therapeutic to promote self-renewal and repair in...
Picking up on that reactive oxygen species (ROS) business from the other day (James Watson's paper suggesting that it could be a key anticancer pathway), I wanted to mention this new paper, called to...
CellCoTec: Ian Paling on Cellular Regeneration Technology and Clinical Trials
In this episode of PharmaTelevision News Review, Fintan Walton talks with Ian Paling, Chairman and CEO at CellCoTec. Filmed at BioTrinity 2010 in Newbury, UK, they discuss: • CellCoTec's Cellular Re...
The Hippo pathway and human cancer
A wealth of recent studies has characterized roles for the Hippo pathway in diverse cancer-relevant processes. This Review discusses our latest understanding of Hippo pathway signalling in cancer, inc...
Study on how Hedgehog signal defines cell-cell interaction receives $747,000 grant
While many researchers believe that the Hedgehog (Hh) signaling pathway, which transmits information to embryonic cells for proper development and is important for regeneration, may actually regulate...
Curis: 4 Reasons To Consider This $4 Stock
ByDerek Chipman:Curis Inc. (CRIS) is a company operating within the biotechnology industry that according to Bloomberg gears its focus to "developing therapeutics for the regeneration and restoration...
Turning One Pathway Off Turns Another On: A Cautionary Tale
Therapies that switch off one cancer-promoting signaling pathway may induce another pathway to switch on. Are we prepared to deal with the consequences? Medscape Hematology-Oncology
Polyvalent DP1 keeps the Wnt pathway neat and tidy
Polyvalent DP1 keeps the Wnt pathway neat and tidyTwo opposite actions of DP1 on the Wnt signalling pathway, one negative in the cytoplasm and one positive in the nucleus, contribute to the generation...
Matching PubMed Articles
MicroRNAs (miRNAs) are known to play important roles in liver regeneration, although the role of miRNAs associated with the termination of liver regeneration is not as well studied. Here we reported t...
Analysis of the role of the integrin signaling pathway in hepatocytes during rat liver regeneration.
To explore the role of the integrin signaling pathway in hepatocytes during rat liver regeneration, the integrin signaling pathway-related gene expression profile in hepatocytes of regenerative liver...
To improve the hydrogen productivity and examine the hydrogen evolution mechanism of Clostridium paraputrificum, roles of formate in hydrogen evolution and effects of introducing formate-originated NA...
PI3 Kinase regulation of neural regeneration and muscle hypertrophy after spinal cord injury.
Spinal cord injury (SCI) is a serious neurotrauma that can lead to life-long disability; to date, no suitable therapeutic strategy exists. Axons do not regenerate after SCI in adult mammals and loss o...
Notch pathway: from development to regeneration of skeletal muscle.
In vertebrates, skeletal muscle is derived from mesodermal structures called somites. Myogenic progenitor cells that form skeletal muscles of the trunk and limbs are derived from the dermomyotome, the...
