Search Results for "Recombinant Factor Vii And Acidosis"
Original Source: Recombinant Activated Factor VII Is Reabsorbed in Renal Proximal Tubules and Is a Ligand to Megalin and Cubilin.
Background/Aims: Recombinant activated factor VIIa (rFVIIa) is used for treatment of haemophilia patients with inhibitors. Tissue distribution studies in rats have shown that injected (125)I-rFVIIa accumulates in organs such as the liver and the kidneys. In this study, we explored which mechanism could be involved in renal clearance of rFVIIa. Methods: Immunohistochemistry was used for examination of the renal distribution in detail after injection of rFVIIa to mice and rats. Surface plasmon resonance evalu...
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Treatment of acute metabolic acidosis: a pathophysiologic approach
Acute metabolic acidosis is common in seriously ill patients, and is associated with increased morbidity and mortality. Rapid recognition of this acid–base disorder and provision of effective therap...
Lactic Acidosis Secondary to Metformin Overdose
A 70-year-old man with type 2 diabetes presented to the ED with severe lactic acidosis after attempting suicide by metformin overdose. How should treatment be approached? Journal of Medical Case Rep...
Fruits, Vegetables Cut Metabolic Acidosis in Kidney Disease
A study has found that the addition of fruits and vegetables to the diets of patients with stage 4 chronic kidney disease improves metabolic acidosis. Medscape Medical News
Fruits/Veggies for Metabolic Acidosis in Kidney Disease?
Fruits and vegetables worked as well as sodium bicarbonate in reducing metabolic acidosis and kidney injury in a small study of patients with late-stage chronic kidney disease (CKD), researchers say....
Adding fruits and vegetables to the diet may help protect the kidneys of patients with chronic kidney disease (CKD) with too much acid build-up, according to a study appearing in an upcoming issue of...
The Product Portfolio Strategy as Decisive Force in Forming the Future Coagulation Factor Market
With over US$ 5.5 bln sales in 2009, the five recombinant products of coagulation factors VIII, IX and VIIa attracted more than 41 projects in the R&D pipeline, 12 of them already in the clin...
Five Servings a Day May Keep Acid Away in CKD (CME/CE)
(MedPage Today) -- SAN DIEGO - Eating more fruits and vegetables can help chronic kidney disease (CKD) patients with borderline metabolic acidosis, researchers said here.
Metformin Safer Than Insulin, Even With Reduced GFR?
No increased risk for death, lactic acidosis, or serious infection was seen in patients with mild renal insufficiency from the Swedish diabetes registry. Medscape Medical News
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Metformin treatment causes persisting lactic acidosis after cardiac arrest.
Metformin associated lactic acidosis (MALA) is a rare condition with a prevalence of 3 per 100,000 patient-years. The reported mortality is about 50%. We describe a case of MALA in a 61- year-old obes...
Preconditioning with hypercapnic acidosis: Hope for the ischemic brain.
Acidosis is an important stress factor triggering cell death under ischemic stress. Accordingly, short acidic pretreatment, i.e. acidic preconditioning, has been used to protect heart and liver. Now t...
Severe Anion Gap Acidosis Associated with Intravenous Sodium Thiosulfate Administration.
INTRODUCTION: Severe anion gap (AG) acidosis associated with intravenous sodium thiosulfate (STS) administration has not been previously described in nondialysis chronic kidney disease (CKD) patients....
Activation of Intrarenal Renin-Angiotensin System during Metabolic Acidosis.
Background: Chronic metabolic acidosis is a common metabolic disturbance and its clinical impact can be severe and extensive. The role and the change of the intrarenal renin-angiotensin system (RAS) d...
Management of metabolic acidosis: does correction with sodium bicarbonate do more harm than good?
Metabolic acidosis is a very common finding in critically ill patients and is associated with increased morbidity and mortality. Metabolic acidosis in critical care patients is commonly the result of...
