Restoring p53 Function in Cancer: Novel Therapeutic Approaches for ...
Restoring p53 Function in Cancer: Novel Therapeutic Approaches for Applying the Brakes to Tumorigenesis. Di Cintio A, Di Gennaro E, Budillon A. ...
http://www.ncbi.nlm.nih.gov/pubmed/19663772...
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Use of p53 for Therapy of Human Cancer
The approaches under study are aimed at restoring the activity of mutant p53 or ...... Bode, AM; Dong, Z. Post-translational modification of p53 in
tumorigenesis. ..... Novel gain-of-function activity of p53 mutants: Activation
of the .... oligonucleotides as a novel therapeutic approach to human breast
cancer: in ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=26...
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MDM2 antagonists induce p53-dependent apoptosis in AML ...
Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J Natl Cancer Inst. 1996;88: 1442-1455. [PubMed]
...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895324/...
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Molecular targeting of cancer: Telomeres as targets
Cancer cells must maintain telomere function despite the tendency of telomeres ... mice also has allowed studies of the role of telomerase in tumorigenesis in
vivo. ... A defect in either of the tumor suppressor genes, p53 or INK4a, ... A
potential limitation of any of these therapeutic approaches is their likely ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=35...
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The molecular genetics of breast cancer and targeted therapy
RAS offers several molecular targets for therapeutic intervention. ...... Bossi G, Sacchi A. Restoration of wild-type p53 function in human cancer: ..... In
vitro propagation of breast tumorigenic cancer cells with stem/progenitor cell
properties. .... Restoring p53-dependent tumor suppression. Cancer Biol Ther.
...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721311/...
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When Mutants Gain New Powers: News From the Mutant p53 Field ...
Indeed, short peptides that disassemble p53R175H from p73 restore the activity of p73 and .... may promote tumorigenesis in the context of chronic inflammation
. ..... A panel of isogenic human cancer cells suggests a therapeutic approach
for ..... Novel gain of function activity of p53 mutants: activation of the ...
http://www.medscape.com/viewarticle/710238_4...
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PARP-1 inhibitors: are they the long-sought genetically specific ...
Thus, one of the therapeutic approaches to kill BRCA1 deficient cancer cells ..... but also, restore the sensitivity to TMZ in resistant tumors 48, 49. ....
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ ... neo
gene from a three-loxP conditional knockout allele by two novel approaches. ...
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1525219/...
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Gene therapy for carcinoma of the breast
It is expected that as new therapeutic targets and approaches are identified .... amplified and functional genes for breast cancer tumorigenesis (dominant
..... P53 function is involved in the cellular response to DNA-damaging events
...... Recombinant antibodies: a novel approach to cancer diagnosis and therapy.
...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=17...
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NIH Research Portfolio Online Reporting Tool (RePORT) - RCDC ...
7 May 2009 ... Ovarian Cancer, OD, 1R21CA134960-01, Novel Ovarian Cancer Detection ... Ovarian Cancer, NCI, 1R21CA133877-01A1, A Low-Dose Decitabine Strategy for Restoring
Ovarian Cancer Sensitivity .... Novel Immunotherapeutic Approaches for Ovarian
Cancer ... ROLES OF MSP58 IN NUCLEAR FUNCTION AND ONCOGENESIS ...
http://report.nih.gov/rcdc/categories/ProjectSearch.aspx?FY=...
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Replication of an E1B 55-Kilodalton Protein-Deficient Adenovirus ...
Nonclonal cell populations were examined, and loss of p53 function was ..... loss of p53 function alone is not sufficient to restore the level of replication
of E1B ... p53 function is a critical and nearly universal event in
tumorigenesis. ... representing the physiologic target for a novel therapeutic
adenovirus, ...
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=22...
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