Search Results for "Role Of Thalidomide In Sarcoidosis"
Original Source: SARCOTHAL. Thalidomide in Skin Sarcoidosis
Sarcoidosis is a multisystem disease involving most frequently the lung, the eyes, the lymph nodes and the skin. Skin lesions may be disfiguring and impair the quality of life. Thalidomide is a multi-target drug that has been shown to be of benefit in skin sarcoidosis in case reports. The objective is to assess the efficacy and tolerance of thalidomide in skin sarcoidosis.
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Progression through the cell cycle is monitored by surveillance mechanisms known as cell cycle checkpoints. Dysfunction in cell cycle checkpoints leads to genomic instability and contributes to tumo...
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. TLRs have become attractive targets for activation or antagonism in pharmaceutical research. TLR ag...
Despite the humorous name, hedgehog signalling cascades are central to embryonic development and has been implicated in the development of a number of diseases, including cancer. The downstream ca...
Myc is the protein encoded by the MYC gene that activates the cell cycle
Myc is the protein encoded by the MYC gene that activates the cell cycle. It promotes cell replication through genetic coding for p14, inhibiting MDM2 and preventing the degradation of the pro-apopt...
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Thalidomide survivors to get £80m grant
The government has set aside £80m to meet the health needs of 325 Thalidomide victims in England over the next decade. It will support them as they approach old age and be paid to the Thalidomid...
Clinical Trial To Treat Chronic Pulmonary Sarcoidosis Enrolling Patients Now
Patients are currently being enrolled in the first clinical trial to investigate the efficacy of immunological therapy for chronic pulmonary sarcoidosis. The trial is being conducted by researchers at...
Increased Hospitalizations Among Sarcoidosis Patients
What has caused the up-tick in admissions for sarcoidosis in the last decade? BMC Pulmonary Medicine
Thalidomide Apology 50 Years Later
Gruenenthal Group's CRO has apologized to mothers who took Thalidomide in the 1950s and 1960s and gave birth to children with congenital birth defects. Exactly 50 years ago today, Thalidomide was pull...
Study reveals sarcoidosis-related mortality rates among black women
A new study conducted by researchers from Boston University has found that sarcoidosis accounts for 25 percent of all deaths among women in the Black Women's Health Study who have the disease. The stu...
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Nasopharyngeal sarcoidosis: a rare involvement.
Sarcoidosis is a chronic, multisystemic, non-caseating granulomatous disease of unknown etiology. Nasopharyngeal involvement is very rare in sarcoidosis. The objective of this report was to evaluate a...
18F-FDG PET/CT for the assessment of myocardial sarcoidosis.
Cardiac involvement portends a poor prognosis inpatients with sarcoidosis. However, due to the non specific clinical manifestations of the disease, patchy myocardial involvement, and the limited diagn...
The Etiologic Role of Infectious Antigens in Sarcoidosis Pathogenesis.
Sarcoidosis is a disease of unknown etiology, characterized pathologically by noncaseating granulomas that most commonly involve the lung, skin, lymph nodes, and eyes. Syndromes with similar pathologi...
Teratogenic effects of thalidomide: molecular mechanisms.
Fifty years ago, prescription of the sedative thalidomide caused a worldwide epidemic of multiple birth defects. The drug is now used in the treatment of leprosy and multiple myeloma. However, its use...
Rheumatologic Manifestations of Sarcoidosis.
Sarcoidosis is a systemic, clinically heterogeneous disease characterized by the development of granulomas. Any organ system can be involved, and patients may present with any number of rheumatologic...
