Search Results for "Rutaecarpine Cyp2e1"
Original Source: Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats.
Although rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been reported to reduce the systemic exposure of caffeine, the mechanism of this phenomenon is unclear. We investigated the microsomal enzyme activity using hepatic S-9 fraction and the plasma concentration-time profiles and urinary excretion of caffeine and its major metabolites after an oral administration of caffeine in the presence and absence of rutaecarpine in rats. Following oral administration of 8...
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Type: Original PaperIsoniazid (INH) and rifampicin (RIF) are the first-line drugs for antituberculosis (anti-TB) chemotherapy. The levels of serum transaminases [aspartate aminotransferase (AST) and a...
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REDDING, Calif., Nov. 6, 2012 /PRNewswire/ -- Creating a new dietary supplement might seem challenging in an industry flooded with products and the possibility of being duplicated by multi-billio...
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Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats.
Although rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been reported to reduce the systemic exposure of caffeine, the mechanism of this phenomenon is un...
Rutaecarpine is an alkaloid of Evodia rutaecarpa which is traditionally used to treat human diseases. Rutaecarpine has been used in combination with other drugs in the treatment of disorders and found...
Mechanism-based inactivation of Human Cytochrome P450 2E1 by Diethyldithocarbamate.
Although disulfiram has been known to inactivate CYP2E1 for more than 20 years, the mechanism has not yet been elucidated. A metabolite of disulfiram, diethyldithocarbamate (DDC), is converted by CYP2...
Wu-Chu-Yu is a well-known herbal drug used for hypertension. Rutaecarpine and evodiamine are main bioactive components of the medicine.
Alcohol steatosis and cytotoxicity: The role of cytochrome P4502E1 and autophagy.
The goal of the current study was to evaluate whether CYP2E1 plays a role in binge-ethanol induced steatosis and if autophagy impacts CYP2E1-mediated hepatotoxicity, oxidative stress and fatty liver f...
