Search Results for "Salinomycin"
Original Source: Salinomycin Selectively Targets 'CD133+' Cell Subpopulations and Decreases Malignant Traits in Colorectal Cancer Lines.
BACKGROUND: Cancer stem-like cells (CSCs) in colorectal cancers (CRC) may account for the failure of treatments because they are resistant to many current anticancer therapies. Salinomycin, a potassium ionophore, was recently identified as a selective inhibitor of breast CSCs. METHODS: The human CRC cell lines HT29 and SW480 were treated with salinomycin and oxaliplatin. Cell viability was determined with cell counting kit 8. Fraction of CD133+ cell subpopulations was assessed by Flow Cytometric analysis. C...
Matching Channels
None
Matching News
Eisai, Versatem In Development Agreement For Small-Molecule Drug
Eisai has agreed with U.S.-based Versatem to collaborate on developing small-molecule drugs based on the U.S. firm's VS-507 (salinomycin) for targeting cancer stem cell.
Eisai and Verastem in a pact for Wnt inhibitors
Verastem announced a research collaboration with Eisai for the next-generation of small molecule Wnt inhibitors. VS-507 is a proprietary formulation of salinomycin and will be the starting point for t...
Verastem Enters Research Collaboration with Eisai for Small Molecule Wnt Inhibitors
Verastem, Inc., (NASDAQ: VSTM) a biopharmaceutical company focused on discovering and developing drugs to treat breast and other cancers by targeting cancer stem cells, announced...
Matching PubMed Articles
Synthesis and antimicrobial activity of amide derivatives of polyether antibiotic-salinomycin.
For the first time a direct and practical approach to the synthesis of eight amide derivatives of polyether antibiotic-salinomycin is described. The structure of allyl amide (3a) has been determined u...
Combination of salinomycin and gemcitabine eliminates pancreatic cancer cells.
Previous research has documented that a subpopulation of pancreatic cancer cells, named cancer stem cells (CSCs), harbor stem cell-like properties. Here, we examined the efficacy of combined treatment...
Salinomycin - a New Cancer Drug Candidate.
Very recently it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis-resist...
Effects of salinomycin on human bone marrow-derived mesenchymal stem cells in vitro.
Various hypotheses on the origin of cancer stem cells (CSCs) exist, including that CSCs develop from transformed human bone marrow mesenchymal stem cells (hBMSC). Since the polyether antibiotic salino...
BACKGROUND: Cancer stem-like cells (CSCs) in colorectal cancers (CRC) may account for the failure of treatments because they are resistant to many current anticancer therapies. Salinomycin, a potassiu...
