Sickle Cell Disease

ImmTAC

Immunocore’s ImmTAC technology enables the immune system to recognise and kill cancer or viral cells. T Cell Receptors naturally recognise diseased cells and Immunocore’s competitive ad...

CD20 Antibodies

The chimeric anti-CD20 antibody rituximab (Rituxan & MabThera) from Biogen Idec and Genentech/Roche is one of the world’s commercially most successful antibodies (2007 sales of over US$ 5 bl...

Anti Infective Peptides

Anti-viral peptides are used to treat infections such as HIV and AIDS, influenza incl. H5N1 strains, hepatitis C virus infections (HCV). Anti-bacterial peptides are used to treat infectiou...

Cytotoxic lymphocyte associated molecule 4 CTLA 4 CD152

Cytotoxic lymphocyte-associated molecule-4 (CTLA-4, CD152) is a member of the CD28 receptor family which is expressed on the surface of Helper T cells. CTLA-4 is similar to the T-cell costimulatory pr...

Sickle cell disease, sickle cell trait are not the same

(HealthDay)—Both sickle cell disease and the condition known as sickle cell trait are genetic blood diseases: You're born with one or the other because of the genes inherited from your parents. Beyo...

New combination therapies with anti-sickling capabilities needed for sickle cell disease

Pain is an undeniable focal point for patients with sickle cell disease but it's not the best focus for drug development, says one of the dying breed of physicians specializing in the condition.

Sickle cell anemia: Maps and newborn estimates released

In 2010 around 300,000 babies were born with sickle cell anemia, a serious blood disorder which can be fatal if untreated, and 5.5 million newborns inherited the sickle cell gene, a new study suggests...

Management of an acute painful sickle cell episode in hospital: summary of NICE guidance

Sickle cell disease comprises a group of lifelong, inherited conditions of haemoglobin formation. Although the sickle gene is found in all ethnic groups, most people affected with sickle cell disease....

Anti-sickling therapies should be focus for sickle cell science

(Medical College of Georgia at Georgia Regents University) Pain is an undeniable focal point for patients with sickle cell disease but it's not the best focus for drug development, says one of the dyi...

Sickle Cell Science Should Focus On Anti-Sickling Therapies

Pain is an undeniable focal point for patients with sickle cell disease but it's not the best focus for drug development, says one of the dying breed of physicians specializing in the condition. Rathe...

Gaps in Care Found for Sickle Cell Disease Patients

MONDAY, Dec. 10 (HealthDay News) -- There are major gaps in medical care for sickle cell disease patients as they move from childhood to adulthood, new research finds. Sickle cell disease is an inher...

Mapping the global burden of sickle cell anaemia

The first rigorous study to assess the global burden of sickle cell anaemia in recent times is reported today in the Lancet, giving an up-to-date view of the distribution of the disease. Accurate esti...

Reproductive Decisions in People With Sickle Cell Disease or Sickle Cell Trait.

In the context of an inherited condition such as sickle cell disease (SCD), it is critical to understand how people with SCD or carriers (sickle cell trait [SCT]) face the challenges of making informe...

Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease.

ABSTRACT: BACKGROUND: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complicati...

Membranoproliferative glomerulonephritis in a postpartum woman with sickle cell disease.

Renal insufficiency occurs in a considerable proportion of patients with sickle cell disease. Common advanced glomerular lesions include focal segmental glomerulosclerosis and nonimmune membranoprolif...

Preoperative Exchange Transfusion for Sickle Cell Disease Patients Undergoing Open-Heart Surgery: An Exception to the Rule.

Abstract Preoperative exchange transfusion is a routine practice in patients with sickle cell disease having elevated sickle cell hemoglobin levels (>40%) undergoing open-heart surgery on cardiopulmon...

Neonatal Screening of Sickle Cell Anemia: A Preliminary Report.

OBJECTIVE: To evaluate feasibility of systematic neonatal screening for sickle cell disease in Chhattisgarh. METHODS:...