RPL554

Verona’s lead drug, RPL554, is a dual phosphodiesterase (PDE) 3 and 4 inhibitor being developed as a novel treatment for chronic obstructive airways disease as COPD (chronic obstructive pulmon...

Kadcyla (ado-trastuzumab emtansine)

Kadcyla™ (ado-trastuzumab emtansine or T-DM1) for the treatment of people with HER2-positive metastatic breast cancer (mBC) who have received prior treatment with Herceptin® (trastuzumab)...

Gastrointestinal Effects

Immunocytokines

Although the human cytokines interleukin-2 (IL-2) and tumor necrosis factor (TNF) alpha are approved marketed for tumor therapy, their use is rather limited due to severe systemic side effects. Targ...

Adverse drug effects

Super-Powerful "Diet Pills" Make Comeback

NEW YORK, Nov. 28, 2012 /PRNewswire/ -- Most of us thought the era of the "Super-Powerful" diet pill ended a few years back when the FDA removed Ephedra and Fen-Phen from the U.S. market because...

Will ‘Side Effects’ Have Side Effects For Pharma?

There have been several movies over the years that have, in various ways, focused on the pharmaceutical industry and the latest to do so is ‘Side Effects,’ the Steve Soderbergh film that d...

Statin Side Effects Are Usually Overcome

Statin side effects commonly make people discontinue treatment, but most patients who go back to them overcome the side effects and remain on their medication long term, researchers from Brigham and W...

Statin Therapy Side Effects Go Away With Persistence

Statin side effects commonly make people discontinue treatment, but most patients who go back to them overcome the side effects and remain on their medication long term, researchers from Brigham and W...

SNPing side effects: Sidebar: Inform Genomics Inc. Corporate Profile

SNPing side effects Inform Genomics Inc. Boston, Mass. Technology: SNP-based test to predict chemotherapy side effects Disease focus: Diagnostic Clinical status: NA Founded: 2010 by Ed Rubenstein, Sus...

Computer model predicts drug side effects

A new set of computer models has successfully predicted negative side effects in hundreds of current drugs, based on the similarity between their chemical structures and those molecules known to cause...

Close to the bone: metabolic effects of glucocorticoids

Long-term glucocorticoid treatment is associated with many dangerous side effects, including weight gain, insulin resistance, diabetes, and osteoporosis; however, the pathological mechanisms that caus...

In Future It May Be Possible To Sniff Out The Side Effects Of Radiotherapy

Researchers at the University of Warwick and The Royal Marsden NHS Foundation Trust have completed a study that may lead to clinicians being able to more accurately predict which patients will suffer...

Patients' attitudes toward side effects of antidepressants: an Internet survey.

Patients' attitudes toward side effects of antidepressants are likely to differ according to gender, which has not yet been fully addressed in the literature. From the 228,310 registrants, 1,305 parti...

Clinical and biomarker predictors of side effects from tamoxifen.

Tamoxifen decreases breast cancer recurrence, mortality, and breast cancer risk in high-risk women. Despite these proven benefits, tamoxifen use is often limited due to side effects. We identified pre...

New tyrosine kinase and EGFR inhibitors in cancer therapy : Cardiac and skin toxicity as relevant side effects. Part A: heart.

Cardiotoxicity is a serious side effect of targeted molecular therapies in cancer treatment. Monoclonal antibodies and tyrosine kinase inhibitors are known to be potent therapies in various neoplastic...

Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.

BACKGROUND: Understanding individual differences in susceptibility to antidepressant therapy side-effects is essential to optimize the treatment of depression.MethodWe performed genome-wide associatio...

Promoting wellness for patients on androgen deprivation therapy: why using numerous drugs for drug side effects should not be first-line treatment.

The controversy over androgen deprivation therapy (ADT) for prostate cancer seems to have shifted over the past decade. The issue of adverse events or side effects now seems to dominate over that of c...