Statins (HMG-CoA reductase inhibitors) - a class of drug used to lower cholesterol levels

Statins (or HMG-CoA reductase inhibitors) are a class of drug used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol...

Fenofibrate / simvastatin benefit in dyslipidemia explored

(HealthDay)—Combination treatment with fenofibrate and simvastatin (FENO-S) significantly reduces postprandial (PP) triglyceride (TG) levels compared with simvastatin alone in all subjects, regardle...

Check dose of simvastatin with amlodipine or diltiazem

Prescribing guidelines for simvastatin have been updated because of an increased risk of myopathy associated with high doses of the drug...

Diabetic Wounds Heal Faster With Topical Simvastatin in Mice

Applying petroleum jelly laced with simvastatin to wounds accelerated healing in diabetic mice. Medscape Medical News

Topical simvastatin may be answer to nonhealing diabetic wounds

Topical simvastatin significantly accelerates wound healing in mice and may be a good treatment option for diabetic patients with nonhealing wounds, say researchers.

Combination of HUCBCs and Simvastatin offers promising therapy for stroke: Study

Researchers at the Henry Ford Health System (Detroit, MI) and colleagues at Saneron CCEL Therapeutics, Inc. of Tampa, Florida, have found that when human umbilical cord blood cells were transplanted i...

Merck & Co to pay $688 million to settle investor law suits; Teva could face $2.1 billion damages

US pharma giant Merck & Co (NYSE: MRK) said yesterday that it has reached an agreement in principle with plaintiffs to resolve two federal securities class-action law suits, agreeing to pay $688 milli...

Topically applied simvastatin enhances wound recovery in diabetic mice

Delayed wound healing is a major complication of diabetes because the physiological changes in tissues and cells impair the wound healing process. This can result in additional disease outcomes such a...

Topical simvastatin shown to accelerate wound healing in diabetes

(Elsevier Health Sciences) Delayed wound healing is a major complication of diabetes because the physiological changes in tissues and cells impair the wound healing process. This can result in additio...

Pleiotropic effects of ezetimibe/simvastatin vs. high dose simvastatin.

In the setting of stable coronary artery disease (CAD), it is not known if the pleiotropic effects of cholesterol reduction differ between combined ezetimibe/simvastatin and high-dose simvastatin alon...

Preparation and In Vitro Evaluation of Simvastatin Ethosome.

Abstract:：To prepare ethosome loading simvastatin,an orthogonal test was applied to optimize the prescriptions, and the qualities of simvastatin ethosome were characterized by the shape, particle si...

Therapeutics. Fenofibrate plus simvastatin did not prevent major CV events more than simvastatin alone in type 2 diabetes.

Effect of simvastatin on the pharmacokinetics of anastrozole.

We have prospectively tested the effects of simvastatin on the pharmacokinetics of anastrozole and on estrogen concentrations in postmenopausal women with hormone receptor-positive breast cancer who w...

Ezetimibe/simvastatin vs simvastatin in coronary heart disease patients with or without diabetes.

ABSTRACT: BACKGROUND: Treatment guidelines recommend LDL-C as the primary target of therapy in patients with hypercholesterolemia. Moreover, combination therapies with lipid-lowering drugs that have d...