Search Results for "Single And Multiple Dose And Pharmacokinetics"
Original Source: Single- and Multiple-Dose Pharmacokinetics of Methylphenidate Administered as Methylphenidate Transdermal System or Osmotic-Release Oral System Methylphenidate to Children and Adolescents With Attention Deficit Hyperactivity Disorder.
This was a 1-month, multicenter, open-label, randomized study to determine single- and multiple-dose pharmacokinetics of d,l-methylphenidate (MPH) after MPH transdermal system (MTS) and osmotic-release oral system MPH (OROS MPH) dosing in children (6-12 years) and adolescents (13-17 years) who had a diagnosis of attention deficit hyperactivity disorder. The pharmacokinetic population consisted of 33 children and 31 adolescents. Accumulation of d-MPH was 34% in children and 57% in adolescents after multiple...
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Multiple sclerosis (MS) is the most common disabling neurological condition affecting 100,000 young adults in the UK. The condition results from autoimmune damage to myelin, causing interference i...
ImuXen® is a liposomal technology platform designed to improve the delivery and effectiveness of DNA, protein and polysaccharide vaccines. Proof of concept preclinical studies with a number of...
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Multiple cone-beam scans fall within acceptable ranges
(HealthDay)—The radiation dose imparted to patients undergoing multiple intraoperative lumbar single cone-beam computed tomography (CT) scans is within the dose range that patients receive during a...
Type: Original PaperThis study investigated the effects of genetic polymorphisms in organic cation transporter (OCT) genes, such as OCT1-3, OCTN1, MATE1, and MATE2-K, on metformin pharmacokinetics. Of...
XenoPort begins Phase I trial of fumarate analog
XenoPort has announced dosing of first patient in the Phase I trial evaluating the pharmacokinetics, safety and tolerability of a single dose of XP23829 administered in both fasted and fed conditions.
Genkyotex’s First in Class NOX Inhibitor GKT137831 to Be Presented at Kidney Week
Genkyotex, the leading developer of NOX inhibitors to treat oxygen-radical mediated diseases, announced today that data from single and multiple dose Phase I studies with the NOX...
Staph Infections Linked to Reuse of Single-Dose Vials
Patients in 2 different clinics acquired Staphylococcus aureus infections after receiving pain medication injections from single-use vials that were used for multiple patients. Medscape Medical News
The AAPS Journal: Pharmacokinetics and Tissue Disposition of Lenalidomide in Mice
Type: Original PaperLenalidomide is a synthetic derivative of thalidomide exhibiting multiple immunomodulatory activities beneficial in the treatment of several hematological malignancies. Murine phar...
All formulations of VIMPAT® (lacosamide) approved in the European Union for initiation as a single loading dose (200 mg) followed by a daily maintenance dose regimen1 UCB announced this week that VIM...
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The aim of the study was to evaluate and compare the pharmacokinetics of lansoprazole (LPZ) and its main metabolites, 5'-hydroxy lansoprazole (HLPZ) and lansoprazole sulfone (LPZS), after single and m...
Pharmacokinetics of single and multiple oral doses of arbidol in healthy Chinese volunteers.
Background: Arbidol is licensed in Russia and China for prophylaxis and treatment of influenza A and B. This study was to assess the pharmacokinetics of single and multiple doses of arbidol in healthy...
Three phase 1 studies of eliglustat tartrate (Genz-112638), an oral inhibitor of glucosylceramide synthase under development for treating Gaucher disease type 1 (GD1), evaluated the safety, tolerabili...
New oral granules of amoxicillin and clavulanic acid in 8:1 ratio have recently been developed and approved to conduct clinical trial in China. To date, there has been no report studying the pharmacok...
Aim:Huperzine A isolated from the Chinese herb Huperzia serrata (Thunb) Trev is a novel reversible and selective AChE inhibitor. The aim of this study was to evaluate the pharmacokinetics and toleranc...
