Ventricular Tachycardia VT

Ventricular tachycardia is a pulse rate of more than 100 beats per minute, with at least three irregular heartbeats in a row. It is a major cause of sudden cardiac death. The condition can develop...

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QT Prolongation and Serum Sotalol Concentration Are Highly Correlated following Intravenous and Oral Sotalol.

Objectives: The aim of this study was to evaluate the correlation between QT interval (QT) and serum sotalol concentration following a single low dose of oral and intravenous sotalol. Methods: Fifteen...

High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations.

The FDA classifies a drug substance as high-permeability when the fraction of dose absorbed (Fabs) in humans is 90% or higher. This direct correlation between human permeability and Fabs has been rece...

Letter by uzun et Al regarding article, "comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study".

Facile preparation of polysaccharide-coated capillaries using a room temperature ionic liquid for chiral separations.

In this study, the dissolution of polysaccharides into an ionic liquid was investigated and applied as a coating onto the capillary walls of a fused-silica capillary in open-tubular CEC (OT-CEC). The...

Sotalol induced torsades de pointes precipitated during treatment with oseltamivir for H1N1 influenza.

BACKGROUND:: Striking prolongation of the QT interval and the morphologically distinctive polymorphic ventricular tachycardia torsades de pointes can occur in patients treated with antiarrhythmic drug...