Structure

PKC (Protein Kinase C)

PKC (protein kinase C) http://www.bioportfolio.com/channels/serine-threonine-protein-kinase-c-pkc is a kinase enzyme and a protein molecule that can change the format of other proteins through chemi...

Serine Threonine protein kinase C PKC

The serine/threonine protein kinase C (PKC) family consists of at least 11 mammalian isozymes belonging to a larger subclass of protein kinases termed the adenine-guanine-cytosine (AGC) kinases. PK...

Tumor Antigens

Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host. Tumor antigens are useful in identifying tumor cells and are potential candidates f...

Bioscience - news, views, reports and blogs

Bioscience - any of the sciences that deal with living organisms.  The study of the nature, behavior, and uses of living organisms as applied to biology. Any of the branches of natural scienc...

[Articles] Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

Hypermethylation of the UTSS region in the TERT promoter is associated with TERT expression in cancers. In paediatric brain tumours, UTSS hypermethylation is associated with tumour progression and poo...

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Cancer cells exhibit several unique metabolic phenotypes that are critical for cell growth and proliferation. Specifically, they overexpress the M2 isoform of the tightly regulated enzyme pyruvate kin...

Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion

Structure of active dimeric human telomerase

EM analyses reveal the three-dimensional structure of human telomerase. Along with functional biochemistry data, the work reveals that telomerase is dimeric in its active form. Each of the two TERT su...

Plasma D-serine levels reduced in schizophrenia

Patients with schizophrenia exhibit significantly lower plasma levels of the amino acid D-serine than mentally healthy individuals, Brazilian researchers report.

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Cancer cells acquire distinct metabolic adaptations to survive stress associated with tumour growth and to satisfy the anabolic demands of proliferation. The tumour suppressor protein p53 (also known...

The TERT variant rs2736100 is associated with colorectal cancer risk

Asymmetric synthesis: Relay catalysis at a boron centre

A boron complex catalyses the addition of allyl groups — hydrocarbon motifs — to 'activated imines' in a relay-like process, generating synthetically useful compounds as single mirror-image isomer...

N-(tert-Butoxycarbonyl)-O-allyl-L-seryl-α-aminoisobutyryl-L-valine methyl ester: a protected tripeptide with an allylated serine residue.

The title compound [systematic name (6S,12S)-methyl 6-(allyloxymethyl)-12-isopropyl-2,2,9,9-tetramethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate], C(21)H(37)N(3)O(7), containing the little st...

Biodegradation of 2-mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate by Pseudomonas desmolyticum NCIM 2112.

2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate is used as supplementary additives in commercial-grade insecticides to compensate for the time factor...

Synthesis and X-ray Structure Determination of Highly Active Pd(II), Pd(I), and Pd(0) Complexes of Di(tert-butyl)neopentylphosphine (DTBNpP) in the Arylation of Amines and Ketones.

The air-stable complex Pd(eta(3)-allyl)(DTBNpP)Cl (DTBNpP = di(tert-butyl)neopentylphosphine) serves as a highly efficient precatalyst for the arylation of amines and enolates using aryl bromides and...

N-Substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization.

Antibiotic resistance is a significant problem and is compounded by the ability of many pathogenic bacteria to form biofilms. A library of N-substituted derivatives of a previously reported 2-aminoimi...

Synthesis of a dimer of β-(1,4)-L-arabinosyl-(2S,4R)-4-hydroxyproline inspired by Art v 1, the major allergen of mugwort.

Nα-tert-Butoxycarbonyl-L-trans-4-hydroxyproline allyl ester (Boc-Hyp-OAll) was glycosylated with 2,3,5-tri-O-benzyl-L-arabinose p-cresylthioglycoside in 60% yield with 4:1 β:α stereoselectivity. De...