Search Results for "Study Of The Health Effect Of Serine"
Original Source: Effect of Betaine, Serine and Folic Acid on Vascular Function in Healthy Volunteers
The purpose of this study is to determine whether reducing the increase in plasma homocysteine concentrations following an oral methionine load affects vascular function in healthy volunteers, irrespective of the homocysteine-lowering agent.
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Public health is the scientific, political and sociological approach by a society to maximise the health of the population through disease preventaion and mainenance of healthy life-styles. The main...
KIACTA™ (also known as eprodisate) is an orally bioavailable small molecule intended for the treatment of AA amyloidosis, an orphan indication that results from long-standing inflammatory cond...
Health IT Information Technology
Why Health IT? Health information technology (Health IT) makes it possible for health care providers to better manage patient care through secure use and sharing of health information - e...
Mental health, although not being as obvious as physical health, is very important, causing great unhappiness to those affected, causing additional physical health problems and costing the economy m...
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Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Cancer cells exhibit several unique metabolic phenotypes that are critical for cell growth and proliferation. Specifically, they overexpress the M2 isoform of the tightly regulated enzyme pyruvate kin...
Plasma D-serine levels reduced in schizophrenia
Patients with schizophrenia exhibit significantly lower plasma levels of the amino acid D-serine than mentally healthy individuals, Brazilian researchers report.
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
Cancer cells acquire distinct metabolic adaptations to survive stress associated with tumour growth and to satisfy the anabolic demands of proliferation. The tumour suppressor protein p53 (also known...
The Medicines Company drops blood loss drug
The Medicines Company has discontinued development of its investigational serine protease inhibitor MDCO-2019 after serious safety issues arose in a Phase IIb study. The study was the only clinical t...
The Medicines Company discontinues phase IIb trial
The Medicines Company has voluntarily discontinued its phase Iib, dose-ranging study of MDCO-2010, a serine protease inhibitor being developed to reduce blood loss during surgery. This action was take...
Renal fibrosis: Antifibrotic effects of a synthetic serine protease inhibitor
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Gabapentin and (S)-pregabalin decrease intracellular d-serine concentrations in PC-12 cells.
The effects of gabapentin (GBP) and (S)-pregabalin (PGB) on the intracellular concentrations of d-serine and the expression of serine racemase (SR) in PC-12 cells were determined. Intracellular d-seri...
The effects of dietary supplementation with 0.5% methionine, 2.5% serine, or both on hyperhomocysteinemia induced by deprivation of dietary choline or by dietary addition of 0.5% guanidinoacetic acid...
Construction of Escherichia coli strains producing L: -serine from glucose.
L: -Serine is usually produced from glycine. We have genetically engineered Escherichia coli to produce L: -serine from glucose intracellularly. D: -3-Phosphoglycerate dehydrogenase (PGDH, EC 1.1.1.95...
Transport systems of serine at the brain barriers and in brain parenchymal cells.
D-Serine is a co-agonist for N-methyl-D-aspartate-type glutamate receptors. Although D-serine levels in cerebrospinal fluid (CSF) and interstitial fluid (ISF) affect central nervous system function, t...
An update on serine deficiency disorders.
Serine deficiency disorders are caused by a defect in one of the three synthesising enzymes of the L-serine biosynthesis pathway. Serine deficiency disorders give rise to a neurological phenotype with...
