Search Results for "Sunitinib"

07:27 EDT 25th May 2015 | BioPortfolio

Original Source: Sunitinib Malate in Patients With Non-Clear Cell Renal Cell Cancer

The goal of this clinical research study is to learn the effectiveness of Sutent® (sunitinib malate, SU011248) in the treatment of patients with non-clear cell renal cell cancer. The safety of sunitinib malate will also be studied.

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Adjuvant treatment with sorafenib or sunitinib does not improve outcomes in localised renal carcinoma

Dr Mark Beresford talks to ecancertv at ASCO GU 2015 reflecting on the initial results of the ASSURE trial where adjuvant treatment with sorafenib or sunitinib is used for localised renal carcinoma...

Gemcitabine-Sunitinib Combo Active in Aggressive RCC

Patients with sarcomatoid or poor-risk renal cell carcinoma (RCC) had frequent objective responses when treated with the combination of gemcitabine (Gemzar) and sunitinib (Sutent), according to the re...

[Articles] Sunitinib in patients with chemotherapy-refractory thymoma and thymic carcinoma: an open-label phase 2 trial

Sunitinib is active in previously treated patients with thymic carcinoma. Further studies are needed to identify potential biomarkers of activity.

Maintenance Sunitinib Improved PFS in Extensive-Stage SCLC

In a phase II study, the use of maintenance sunitinib improved progression-free survival among patients with untreated extensive-stage small-cell lung cancer.

Sorafenib nor Sunitinib Effective As Adjuvant Kidney Cancer Therapy

Neither sunitinib nor sorafenib reduced disease recurrence in patients with locally advanced renal cell carcinoma (RCC) when these agents were given to patients as adjuvant therapy, according to the r...

Tackling renal cancer with a combination of autologous immunotherapy and sunitinib

Prof Figlin talks to ecancertv at ASCO GU 2015 about the use of sunitinib in renal cancer when combined with AGS-003, an autologous immunotherapy designed to induce an immune response to a patient...

Sunitinib Active in Advanced Thymic Carcinoma

Sunitinib is active in advanced thymic carcinoma, concludes the first clinical trial of the drug in heavily pretreated patients. Medscape Medical News

Implications of using adjuvant sorafenib and sunitinib in unfavourable renal carcinoma

Dr Naomi Balzer-Haas talks to ecancertv at ASCO GU 2015 about the initial results from the phase III ASSURE trial. It appears that adjuvant sorafenib or sunitinib do not benefit patients with unfavo...

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AXL as a modulator of sunitinib response in glioblastoma cell lines.

Receptor tyrosine kinase (RTK) targeted therapy has been explored for glioblastoma treatment. However, it is unclear which RTK inhibitors are the most effective and there are no predictive biomarkers ...

Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition.

The angiogenesis inhibitor sunitinib is a tyrosine kinase inhibitor that acts mainly on the VEGF and PDGF pathways. We have previously shown that sunitinib is sequestered in the lysosomes of exposed t...

Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662.

Previously published pharmacokinetics (PK) models for sunitinib and its active metabolite SU12662 were based on a limited dataset or lacked important elements such us correlations between sunitinib an...

Sunitinib Achieved Fast and Sustained Control of VIPoma Symptoms.

Background: VIPomas are rare functioning neuroendocrine tumors (NET). Vasointestinal peptide (VIP) overproduction leads to the Verner-Morrison syndrome, whose management is challenging when refractory...

Efficacy and toxicity of sunitinib for non clear cell renal cell carcinoma (RCC): A systematic review of the literature.

The randomized phase III trial of sunitinib versus interferon Alfa provided level-A evidence for the use of sunitinib in advanced clear cell renal cell carcinoma (RCC). This systematic literature revi...

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