Search Results for "Superoxide Dismutase In Sickle Cell Diseases"
Original Source: Temporal and regional changes of superoxide dismutase and glutathione peroxidase activities in rats exposed to focal cerebral ischemia.
Reactive oxygen species are important cause of tissue injury during cerebral ischemia and reperfusion (I/R). Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) are intracellular enzymes responsible for endogenous antioxidant defense of tissues affected by I/R. The aim of this study was to examine temporal and regional changes of SOD and GSH-Px activities in animals exposed to transient focal cerebral ischemia. Male Wistar Hannover rats were subjected to the right middle cerebral artery occlusion...
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[Galera Therapeutics] brings in $11mm in Series A funds
[Galera Therapeutics Inc.] (developing drugs that target the oxygen metabolic pathways) has raised $11mm through its Series A round. New Enterprise Associates and Novartis Venture Funds co-led the rou...
Sickle cell disease, sickle cell trait are not the same
(HealthDay)—Both sickle cell disease and the condition known as sickle cell trait are genetic blood diseases: You're born with one or the other because of the genes inherited from your parents. Beyo...
Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis
Loss of Extracellular Superoxide Dismutase Induces Severe IL-23-Mediated Skin Inflammation in Mice
Protection Against Dangers Of Oxygen Offered By "Super" Enzyme
Just like a comic book super hero, you could say that the enzyme superoxide dismutase (SOD1) has a secret identity. Since its discovery in 1969, scientists believed SOD1's only role was to protect liv...
Sickle cell anemia: Maps and newborn estimates released
In 2010 around 300,000 babies were born with sickle cell anemia, a serious blood disorder which can be fatal if untreated, and 5.5 million newborns inherited the sickle cell gene, a new study suggests...
Matching PubMed Articles
Continuous reactive oxygen species (ROS) production in individuals with sickle cell disease (SCD) may alter their overall redox status and cause tissue damage. The aim of this study was to evaluate ox...
A common cause of amyotrophic lateral sclerosis is mutations in superoxide dismutase-1, which provoke the disease by an unknown mechanism. We have previously found that soluble hydrophobic misfolded m...
A novel, highly sensitive superoxide dismutase biosensor for the direct and simultaneous determination of superoxide radicals was developed by immobilization of superoxide dismutase within carboxymeth...
Reproductive Decisions in People With Sickle Cell Disease or Sickle Cell Trait.
In the context of an inherited condition such as sickle cell disease (SCD), it is critical to understand how people with SCD or carriers (sickle cell trait [SCT]) face the challenges of making informe...
Metallation state of human manganese superoxide dismutase expressed in Saccharomyces cerevisiae.
Human manganese superoxide dismutase (Sod2p) has been expressed in yeast and the protein purified from isolated yeast mitochondria, yielding both the metallated protein and the less stable apoprotein...
