Search Results for "Surfactant Deficiency"
Original Source: Surfactant Protein D Deficiency Increases Lung Injury during Endotoxemia.
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are major causes of acute respiratory failure with high rates of morbidity and mortality. While SP-D plays a critical role in pulmonary innate immunity and several clinical studies suggest that this protein may be implicated in the pathophysiology of ARDS, little is known regarding the function of SP-D in ARDS. In the present study, we induced indirect lung injury by intraperitoneal injection of LPS and direct lung inju...
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Frank vitamin E deficiency is rare and overt deficiency symptoms have not been found in healthy people who obtain little vitamin E from their diets. Premature babies of very low birth weight (<1,...
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Type: Original PaperSelf-emulsifying oil/surfactant mixtures can be incorporated into pellets that have the advantages of the oral administration of both microemulsions and a multiple-unit dosage form...
CPAP as good as surfactant in extremely premature babies
NEW YORK (Reuters Health) - An updated assessment of extremely-premature infants has confirmed that early treatment with continuous positive airway pressure (CPAP) lowers the risk of death or neur...
Victorian Wallpaper in Your Lungs
[caption id="attachment_4287" align="aligncenter" width="560" caption="Lung Surfactant image (C) The Biophysical Society. "] [/caption]No William Morris didn't design this 18th century simulacrum...
Vitamin B12 Deficiency Prevalent Among Refugees
New research from the University of Adelaide has discovered a high prevalence of vitamin B12 deficiency among refugees, prompting calls for refugees to be routinely screened for the problem soon after...
Type: Original PaperPurposeTo study the effect of three nonionic surfactants on the protein-silicone oil interactions.MethodsThe adsorption of Tween® 80, Pluronic® F68 and Tween® 20 at the silicone...
Type: Original PaperNanoemulsions are increasingly being investigated for their fascinating capability of loading both hydrophobic and hydrophilic molecules while their stability is still an issue, be...
Vitamin D deficiency may contribute to alcohol-related muscular weakness
Myopathy refers to a muscular disease in which muscle fibers do not function, resulting in muscular weakness and wasting. Vitamin D deficiency is a well-recognized cause of myopathy, and excessive dri...
Changes in hemodynamics after rescue surfactant administration
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BACKGROUND: Surfactant deficiency is the pivotal abnormality in Neonatal and Acute Respiratory Distress Syndrome. Surfactant deactivation can produce hypoxemia, loss of lung compliance, and pulmonary...
Fatal respiratory failure in a full-term newborn with two ABCA3 gene mutations: a case report.
Genetic mutations associated with pulmonary surfactant protein deficiency are associated with diverse clinical phenotypes. Mutations of the surfactant protein B and C genes were the first to be descri...
Vasoactive intestinal peptide (VIP) is a major neurotransmitter in the lungs and regulates many aspects of pulmonary functions. Pulmonary surfactant (PS), a complex mixture of lipids and proteins, pro...
The surfactant lipid transporter ABCA3 is N-terminally cleaved inside LAMP3-positive vesicles.
ABCA3 mutations cause fatal surfactant deficiency and interstitial lung disease. ABCA3 protein is a lipid transporter indispensible for surfactant biogenesis and storage in lamellar bodies (LB). The p...
Effect of Surfactant Hydrophobicity on the Pathway for Unfolding of Ubiquitin.
This paper describes the interaction between ubiquitin (UBI) and three sodium n-alkyl sulfates (SC(n)S) that have the same charge (Z = -1) but different hydrophobicity (n = 10, 12, or 14). Increasing...
