Search Results for "Synergistic Wnt Tlr4"
Original Source: Mechanical strain and TLR4 synergistically induce cell-specific inflammatory gene expression in intestinal smooth muscle cells and peritoneal macrophages.
Mechanical trauma of the gut is an unavoidable event in abdominal surgery. Former studies demonstrated that intestinal manipulation induces a strong inflammation within the tunica muscularis. We hypothesized that mechanical strain initiates or aggravates proinflammatory responses in intestinal smooth muscle cells (iSMC) or macrophages. First, an appropriate isolation and culture method for neonatal rat iSMC was established. Purified iSMC and primary peritoneal macrophages (pMacs) were subjected to static or...
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Signalling: PI3Kδ keeps TLR4 signalling on track
PI3Kδ regulates TLR4 signalling by controlling the subcellular localization of TLR4 and TIRAP.
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Excess free fatty acids (FFAs) are known to induce insulin resistance, and a role for TLR4 has been implicated in this process. But FFAs are believed to be incapable of binding TLR4 directly. In a new...
The TLR4 antagonist Eritoran protects mice from lethal influenza infection
There is a pressing need to develop alternatives to annual influenza vaccines and antiviral agents licensed for mitigating influenza infection. Previous studies reported that acute lung injury caused...
Scientists uncover new role for TLR4 in development of tissue fibrosis or scarring
An international multi-disciplinary research team led by Northwestern Medicine scientists has uncovered a new role for the protein toll-like receptor 4 (TLR4) in the development of tissue fibrosis, or...
TLR4 signaling shifts from plasma membrane TIRAP-MyD88–mediated pathways to endosomal TRAM-TRIF–mediated signaling. Vanhaesebroeck and colleagues show that the kinase PI(3)K p110δ is required for...
Pathway Discovered That Has Potential Implications For Scleroderma Therapy
An international multi-disciplinary research team led by Northwestern Medicine scientists has uncovered a new role for the protein toll-like receptor 4 (TLR4) in the development of tissue fibrosis, or...
NovImmune Initiates Phase I Clinical Study with First-in-Class Anti-TLR4 Monoclonal Antibody
NovImmune SA initiated dosing in a Phase I clinical trial of NI-0101, a monoclonal antibody drug candidate targeting toll-like receptor-4 (TLR4). NI-0101 was discovered a...
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Bacterial endotoxin lipopolysaccharide (LPS) is a potent immune stimulant, with the recognition of LPS and its active principal lipid A mediated by the Toll-like receptor 4 (TLR4)/MD-2 receptor comple...
A Synthetic Lipid A Mimetic Modulates Human TLR4 Activity.
The sincerest form of flattery! A novel, symmetric lipid A mimetic (D1) formed by two glucose units linked through a 6-6' succinic diamide linker is active in modulating the activity of human TLR4....
Islet allografts from donor mice exposed to CO are protected from immune rejection after transplantation via the suppression of membrane trafficking/activation of TLR4 in islets/beta cells. The molecu...
Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2.
Development of contact allergy requires cooperation of adaptive and innate immunity. Ni(2+) stimulates innate immunity via TLR4/MD2, the bacterial LPS receptor. This likely involves receptor dimerizat...
Photoreceptor cells constitutively express functional TLR4.
Toll-like receptor 4 (TLR4) is expressed on a number of cells including neurons in the brain. However, it has yet to be determined if TLR4 is expressed on photoreceptor cells in the retina. In this re...
