Atrioventricular Block

Thirddegree AV block

Bundle Branch and Fascicular Block

Brilinta (TM) - ticagrelor, AstraZeneca's new heart drug

Brilinta - ticagrelor, AstraZeneca's new heart drug is a blood-thinning medicine designed to prevent dangerous blood clots in patients with serious chest pain or previous heart attacks. It re...

Sinus Node Dysfunction

Sinus node dysfunction refers to a number of conditions producing physiologically inappropriate atrial rates. Symptoms may be minimal or include weakness, palpitations, and syncope. Diagnosis is by...

Human medicines European Public Assessment Report (EPAR): Clopidogrel Zentiva (previously Clopidogrel Winthrop), clopidogrel, Revision: 11, Authorised

Human medicines European Public Assessment Report (EPAR): Clopidogrel Apotex (previously Clopidogrel Mylan Pharma), clopidogrel, Revision: 5, Authorised

Human medicines European Public Assessment Report (EPAR): Clopidogrel Apotex (previously Clopidogrel Mylan Pharma), clopidogrel, Revision: 6, Authorised

Clopidogrel before PCI yields no significant mortality benefit

NEW YORK (Reuters Health) - Patients who receive clopidogrel before scheduled percutaneous coronary intervention (PCI) with stent placement are less apt to suffer major adverse cardiac events but...

Attenuated Benefit With Clopidogrel Therapy in Nonsmokers

Researchers examine data from the large-scale studies that established clopidogrel in clinical practice and conclude that these same studies consistently support "less or no clinical efficacy from clo...

WOEST supports clopidogrel only in PCI patients on anticoagulation

Publication of the WOEST trial results reaffirm the study’s major finding that antiplatelet therapy with clopidogrel alone is preferable to the use of both aspirin and clopidogrel in patients underg...

Treatment With Clopidogrel After Myocardial Infarction—Reply

In Reply: As pointed out by Dr Lin and colleagues, diverging data regarding clopidogrel efficacy between men and women have been reported repeatedly and have caused concerns as to whether women benefi...

New Analysis Questions Clopidogrel Pretreatment Prior to PCI

The only people who gained a benefit from pretreatment with clopidogrel before PCI were the highest-risk STEMI patients, a new meta-analysis suggests. The time has come to question the blanket recomme...

Interaction of clopidogrel and omeprazole.

To the Editor: The label for clopidogrel warns physicians to "avoid concomitant use of . . . strong or moderate CYP2C19 inhibitors." Such inhibitors (e.g., omeprazole) decrease the formation of the...

New clopidogrel napadisilate salt and its solid dispersion with improved stability and bioequivalence to the commercial clopidogrel bisulphate salt in beagle dogs.

The purpose of this study was to develop a novel clopidogrel napadisilate-loaded solid dispersion with improved stability and bioequivalence to the clopidogrel bisulphate-loaded commercial product. Cl...

Allergic Reactions to Clopidogrel and Cross-Reactivity to Other Agents.

Clopidogrel is a widely used antiplatelet agent, particularly after coronary stent implantation. About 1% of patients have allergic or hematologic adverse reactions to clopidogrel. This has important...

Toxicity of clopidogrel and ticlopidine on human myeloid progenitor cells: importance of metabolites.

Ticlopidine and clopidogrel are thienopyridine derivatives used for inhibition of platelet aggregation. Not only hepatotoxicity, but also bone marrow toxicity may limit their use. Aims of the study we...

High leukocyte count and interleukin-10 predict high on-treatment-platelet-reactivity in patients treated with clopidogrel.

According to recent trials, a significant number of patients do not have a completely effective response to clopidogrel. The aim of the study was to evaluate the rate of clopidogrel resistance in the...