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Search Results for "Target Identification Protein Small Molecule"

13:28 EDT 27th September 2016 | BioPortfolio

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Small-molecule control of protein function through Staudinger reduction

A generally applicable small-molecule switch for protein function in live cells has been developed based on selective protein protection using unnatural amino acid mutagenesis and a bioorthogonal depr...

Targeting RNA-Binding Proteins

An RNA-binding protein fused with the catalytic domain of an RNA-editing enzyme makes for easier identification of the binding protein's target—a boon for studying gene expression and cellular f...

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

The biological rationale for targeting protein–protein interactions as a therapeutic strategy is strong, but identifying viable small-molecule drugs to achieve this has proved highly challenging. Th...

Proteome-wide covalent ligand discovery in native biological systems

Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes...

Cantabio signs deal with PRF to advance development work on targeting DJ-1 protein small molecule pharmaceutical chaperone drug candidates

Cantabio Pharmaceuticals has signed an agreement with Purdue Research Foundation (PRF) to advance the company’s development work on targeting DJ-1 protein small molecule pharmaceutical chaperone dru...

Hua Xu, Principal Scientist at Pfizer, to Present at Drug Design & Medicinal Chemistry Mtg

Boston, MA, July 19, 2016 --(PR.com)-- Hua Xu, Principal Scientist of Worldwide Medicinal Chemistry at Pfizer, will give a presentation on, “Chemical Biology Tools for Target IdentificationR...

MAb characterisation course could reskill small molecule API workers, NIBRT

Interested in moving from small to large molecule manufacturing? An upcoming course will address mAb characterisation challenges and offer hands-on experience for small molecule manufacturers , says N...

Researchers describe key protein structure and a drug prototype that could assist therapeutic development

Researchers from the University of Chicago have described the three-dimensional, atomic structure of an important cell receptor molecule linked to the development of several diseases, including melano...

Matching PubMed Articles

Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.

The HIV-1 CA protein is an attractive therapeutic target for the development of new antivirals. An inter-protomer pocket within the hexamer configuration of the CA, which is a binding site for key hos...

SPLINTS: small-molecule protein ligand interface stabilizers.

Regulatory protein-protein interactions are ubiquitous in biology, and small molecule protein-protein interaction inhibitors are an important focus in drug discovery. Remarkably little attention has b...

Selectivity determination of a small molecule chemical probe using protein microarray and affinity capture techniques.

Small molecule selectivity is an essential component of candidate drug selection and target validation. New technologies are required to better understand off-target effects, with particular emphasis ...

Small-Molecule PROTACS: New Approaches to Protein Degradation.

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inh...

Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin.

15-Deoxyspergualin (DSG) is an immunosuppressive agent being clinically used. Unlike tacrolimus and cyclosporine A, it does not inhibit the calcineurin pathway, and its mechanism of action and target ...

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