Advertisement

Topics

Search Results for "Target Identification Protein Small Molecule"

01:54 EDT 29th July 2016 | BioPortfolio

Matching Channels

Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

Matching News

Small-molecule control of protein function through Staudinger reduction

A generally applicable small-molecule switch for protein function in live cells has been developed based on selective protein protection using unnatural amino acid mutagenesis and a bioorthogonal depr...

Targeting RNA-Binding Proteins

An RNA-binding protein fused with the catalytic domain of an RNA-editing enzyme makes for easier identification of the binding protein's target—a boon for studying gene expression and cellular f...

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

The biological rationale for targeting protein–protein interactions as a therapeutic strategy is strong, but identifying viable small-molecule drugs to achieve this has proved highly challenging. Th...

Sanofi, DiCE form discovery collaboration

Sanofi (Euronext:SAN; NYSE:SNY) and DiCE Molecules SV LLC (Redwood City, Calif.) entered a five-year collaboration on Wednesday to co-develop small molecules against up to 12 targets using DiCE's smal...

Proteome-wide covalent ligand discovery in native biological systems

Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes...

Small molecule slows down ticking of the biological clock

A group of biologists, theoretical chemists and synthetic chemists at ITbM have come together to develop a small molecule that slows down the circadian clock rhythm through binding to the CRY clock pr...

Cantabio signs deal with PRF to advance development work on targeting DJ-1 protein small molecule pharmaceutical chaperone drug candidates

Cantabio Pharmaceuticals has signed an agreement with Purdue Research Foundation (PRF) to advance the company’s development work on targeting DJ-1 protein small molecule pharmaceutical chaperone dru...

Vanquish Oncology’s small molecule could trigger selective cancer cell death

The drug works by activating a protein called procaspase-3 that triggers

Matching PubMed Articles

Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.

The HIV-1 CA protein is an attractive therapeutic target for the development of new antivirals. An inter-protomer pocket within the hexamer configuration of the CA, which is a binding site for key hos...

SPLINTS: small-molecule protein ligand interface stabilizers.

Regulatory protein-protein interactions are ubiquitous in biology, and small molecule protein-protein interaction inhibitors are an important focus in drug discovery. Remarkably little attention has b...

Small-Molecule PROTACS: New Approaches to Protein Degradation.

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inh...

Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin.

15-Deoxyspergualin (DSG) is an immunosuppressive agent being clinically used. Unlike tacrolimus and cyclosporine A, it does not inhibit the calcineurin pathway, and its mechanism of action and target ...

Cell-based selection expands the utility of DNA-encoded small-molecule library technology to cell surface drug targets: Identification of novel antagonists of the NK3 tachykinin receptor.

DNA-encoded small-molecule library technology has recently emerged as a new paradigm for identifying ligands against drug targets. To date, this technology has been used with soluble protein targets t...

Search Whole site using Google

Loading
Quick Search
Advertisement
 
Advertisement Advertisement