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Search Results for "Target Identification Protein Small Molecule"

00:51 EDT 24th August 2017 | BioPortfolio

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Small Molecule API Market Is Expected to Grow at a CAGR of 7% from 2016 to 2027

Market Synopsis of Small Molecule API Market: Market Scenario: Globally the market for small molecule API is increasing rapidly. The major factors that drive the growth of small molecule API are rise ...

Synthetic compound linked to hunger-hormone production

New research suggests that a man-made cousin of a small molecule found in olive oil can disrupt the hunger-signaling pathway. Researchers identified this promising new target by screening a library o...

Small Molecule API Market Research, Analysis, Opportunities - Global Forecast to 2027

PUNE, MAHARASHTRA, INDIA, August 16, 2017 / EINPresswire.com / -- Market Synopsis of Small Molecule API Market: Market Scenario: Globally the market for small molecule API is increasing rapidly. The m...

BI and Philogen collaborate in small-molecule therapeutics

Boehringer Ingelheim GMBH entered into a multi-target collaboration and license agreement with Philogen SPA to discover and optimize small-molecule therapeutics for serious unmet medical conditions. ...

Biochemists link synthetic compound to hunger-hormone production

New research suggests that a man-made cousin of a small molecule found in olive oil can disrupt the hunger-signaling pathway. Researchers identified this promising new target by screening a library of...

De novo design of a hyperstable non-natural protein–ligand complex with sub-Å accuracy

The first demonstration of a protein designed entirely from first principles that binds a small-molecule cofactor in a precisely predetermined orientation has now been described. The design method uti...

Small-molecule phenotypic screening with stem cells

To fully leverage the potential of human-induced pluripotent stem cells (hiPSCs), improved and standardized reprogramming methods and large-scale collections of hiPSC lines are needed, and the stem ce...

Developing Spindlin1 small-molecule inhibitors by using protein microarrays

Matching PubMed Articles

Single-molecule protein identification by sub-nanopore sensors.

Recent advances in top-down mass spectrometry enabled identification of intact proteins, but this technology still faces challenges. For example, top-down mass spectrometry suffers from a lack of sens...

Targeted protein knockdown using small molecule degraders.

Small molecule probes of biological systems have traditionally been designed to bind to and inhibit the active sites of their protein targets. While this class of pharmacological agents has been broad...

Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly.

Domain swapping is the process by which identical proteins exchange reciprocal segments to generate dimers. Here we introduce induced domain swapping (INDOS) as a mechanism for regulating protein func...

Development of a small hybrid molecule that mediates degradation of His-tag fused proteins.

In recent years, the induction of target-protein degradation via the ubiquitin-proteasome system (UPS) mediated by small molecules has attracted attention, and this approach has applications in pharma...

Identification of aminosulfonylarylisoxazole as microRNA-31 regulators.

The discovery of small-molecule regulators of microRNAs remains challenging, but a few have been reported. Herein, we describe small-molecule inhibitors of miR-31, a tumor-associated microRNA (miRNA),...

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