Search Results for "Target Identification Protein Small Molecule"

15:48 EDT 28th April 2015 | BioPortfolio

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Hybrigenics Corp

Hybrigenics Services was founded on its optimized ULTImate Y2H™ technologies enabling the identification of protein binding partners of any protein (i.e., soluble, membrane-bound, post-translational...

Small molecule could pave way for novel vaccine adjuvants

Identification and characterisation of a small molecule that targets protein receptors that stimulate the immune system could lead to novel vaccine adjuvants and anti-tumour agents.

Small molecule–triggered Cas9 protein with improved genome-editing specificity

Directly modulating the activity of genome-editing proteins has the potential to increase their specificity by reducing activity following target locus modification. We developed Cas9 nucleases that a...

New Developments in Characterizing Protein-Small Molecule Interactions for Drug Discovery

Isothermal titration calorimetry (ITC) is a highly valuable technique that is used throughout drug discovery workflow to study the binding interactions of proteins and small molecules. It is an essent...

Alliance Pharma

Alliance Pharma is a Contract Research Organization (CRO) specializing in Drug Metabolism and Pharmacokinetic (DMPK) and bioanalytical services for both small and large molecules. Our extensive and di...

UK firms target small molecule cancer drugs

Phylogica has entered into an agreement with PhoreMost, a biotechnology company, to identify and develop small molecule cancer drugs.

3-phosphoinositide dependent protein kinase-1 (PDPK1); protein kinase B (AKT; AKT1; PKB; PKBA); ribosomal protein S6 kinase 70kDa polypeptide 1 (RPS6KB1; S6K1)

In vitro studies suggest that small molecule allosteric inhibitors of

Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells

Small molecules that specifically activate an intracellular protein of interest are highly desirable. A generally applicable strategy, however, remains elusive. Herein we describe a small molecule–t...

Matching PubMed Articles

Design of High Throughput Screening Assays and Identification of a SUMO1-Specific Small Molecule Chemotype Targeting the SUMO-Interacting Motif-Binding Surface.

Protein-protein interactions are generally challenging to target by small molecules. To address the challenge, we have used a multi-disciplinary approach to identify small-molecule disruptors of prote...

Substrate Pathways in the Nitrogenase MoFe Protein by Experimental Identification of Small Molecule Binding Sites.

In the nitrogenase molybdenum-iron (MoFe) protein, we have identified five potential substrate access pathways from the protein surface to the FeMo-cofactor (the active site) or the P-cluster using ex...

Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/clinical perspectives.

Medicinal chemistry strategies have contributed to the development, experimental study of and clinical trials assessment of the first type of protein kinase small molecule inhibitor to target the Janu...

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attracti...

Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery.

Heat shock protein 90 (Hsp90) is an adenosine triphosphate dependent molecular chaperone in eukaryotic cells that regulates the activation and maintenance of numerous regulatory and signaling proteins...

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