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Search Results for "Target Identification Protein Small Molecule"

20:47 EDT 23rd April 2014 | BioPortfolio

Original Source: Identification of direct protein targets of small molecules.

Small-molecule target identification is a vital and daunting task for the chemical biology community as well as for researchers interested in applying the power of chemical genetics to impact biology and medicine. To overcome this "target ID" bottleneck, new technologies are being developed that analyze protein-drug interactions, such as drug affinity responsive target stability (DARTS), which aims to discover the direct binding targets (and off targets) of small molecules on a proteome scale without requir...

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian,...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Bayer exercises option on X-Chem epigenetic-targeting compound

Bayer HealthCare Pharmaceuticals AG exercised an option from X-Chem Inc. (small-molecule drug discovery) on an early-stage small molecule that inhibits an epigenetic protein. The partners began collab...

Cancer, arthritis treatments could target same 'glue' molecule

Two very different diseases, rheumatoid arthritis and some cancers, share a common feature - an over-abundance of a "glue" molecule that helps cells stick together. Now, a new study suggests targeting...

The Latest Protein-Protein Compounds

Here's a review of protein-protein interaction "hot spots" and their application to drug discovery. There have been several overviews like this over the years. This one doesn't break much new ground,...

Oncogenic protein interfaces: small molecules, big challenges

This Review describes some of the latest techniques that are being used to discover modulators of protein–protein interactions and how current drug discovery approaches have been adapted to successf...

Protein folding becomes cancer treatment target

(Medical Xpress)—A molecule that helps cancer cells to keep dividing could be a promising target for new treatments, according to research published in the journal Oncogene.

Labeling: Palladium brings proteins to life

A bioorthogonal decaging strategy, mediated by small-molecule palladium compounds, can recover the lysine-dependent activity of cellular proteins. This activation technique could be generally applicab...

Possible new target for future brain cancer drugs

A molecule in cells that shuts down the expression of genes might be a promising target for new drugs designed to treat glioblastoma, the most frequent and lethal form of brain cancer. The findings su...

Small Molecule Shows Potential in Advanced Cancers

Cleveland BioLabs Inc. announced the achievement of all objectives in a Phase 1 clinical trial of CBL0102, or quinacrine, an orally administered small molecule.Read

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Ribosome Display and Photo-Crosslinking Techniques for In vitro Identification of Target Proteins of Bioactive Small Molecules.

The identification of target proteins of bioactive small molecules as bioprobe candidates or drug seeds is indispensable for elucidating their actions and predicting their side effects. To meet the cu...

Phenotypic Screening to Identify Small-Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy.

Small-molecule glucose uptake enhancers targeted to myotubes and adipocytes were developed through a phenotypic screening linked with target identification and rational optimization. The target protei...

SEC-TID: A Label-Free Method for Small-Molecule Target Identification.

Bioactive small molecules are an invaluable source of therapeutics and chemical probes for exploring biological pathways. Yet, significant hurdles in drug discovery often come from lacking a comprehen...

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.

Phenotypic screening is making a comeback in drug discovery as the maturation of chemical proteomics methods has facilitated target identification for bioactive small molecules. A limitation of these...

A fluorescence-based high throughput assay for the determination of small molecule-human serum albumin protein binding.

Herein, we describe the development of a fluorescence-based high throughput assay to determine the small molecule binding towards human serum albumin (HSA). This innovative competition assay is based...

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