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Search Results for "Target Identification Protein Small Molecule"

04:18 EDT 26th June 2016 | BioPortfolio

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

The biological rationale for targeting protein–protein interactions as a therapeutic strategy is strong, but identifying viable small-molecule drugs to achieve this has proved highly challenging. Th...

Sanofi, DiCE form discovery collaboration

Sanofi (Euronext:SAN; NYSE:SNY) and DiCE Molecules SV LLC (Redwood City, Calif.) entered a five-year collaboration on Wednesday to co-develop small molecules against up to 12 targets using DiCE's smal...

Proteome-wide covalent ligand discovery in native biological systems

Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes...

Figure: Binding SMART

Warp's independence day Binding SMART Warp Drive Bio LLC's Small Molecule Assisted Receptor Targeting (SMART) technology allows a small molecule to inhibit intracellular protein-protein interactions b...

Small molecule slows down ticking of the biological clock

A group of biologists, theoretical chemists and synthetic chemists at ITbM have come together to develop a small molecule that slows down the circadian clock rhythm through binding to the CRY clock pr...

Promega NanoLuc NanoBRET target engagement technology

Promega NanoLuc technology has been used to directly assess the dynamic process of target engagement in live cancer cells. The company’s scientists have developed a method for use in drug discovery ...

Vanquish Oncology’s small molecule could trigger selective cancer cell death

The drug works by activating a protein called procaspase-3 that triggers

MAb characterisation course could reskill small molecule API workers, NIBRT

Interested in moving from small to large molecule manufacturing? An upcoming course will address mAb characterisation challenges and offer hands-on experience for small molecule manufacturers , says N...

Matching PubMed Articles

An in solution assay for interrogation of affinity and rational minimer design for small molecule-binding aptamers.

Aptamers are short single-stranded oligonucleotides that fold into unique three-dimensional structures, facilitating selective and high affinity binding to their cognate targets. It is not well unders...

Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.

The HIV-1 CA protein is an attractive therapeutic target for the development of new antivirals. An inter-protomer pocket within the hexamer configuration of the CA, which is a binding site for key hos...

Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors.

Application of safety lead optimization screening strategies during the early stage of drug discovery led to the identification of a series of CNS-active small molecule inhibitors with opioid off-targ...

SPLINTS: small-molecule protein ligand interface stabilizers.

Regulatory protein-protein interactions are ubiquitous in biology, and small molecule protein-protein interaction inhibitors are an important focus in drug discovery. Remarkably little attention has b...

Small-Molecule PROTACS: New Approaches to Protein Degradation.

The current inhibitor-based approach to therapeutics has inherent limitations owing to its occupancy-based model: 1) there is a need to maintain high systemic exposure to ensure sufficient in vivo inh...

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