Search Results for "Target Identification Protein Small Molecule"

06:39 EDT 26th June 2017 | BioPortfolio

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...


PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Non-kinase targets of protein kinase inhibitors

Inhibition of proteins other than the intended target by small molecules can lead to the incorrect assignment of biological functions to particular proteins and wasted drug development efforts. Potent...

Small-molecule phenotypic screening with stem cells

To fully leverage the potential of human-induced pluripotent stem cells (hiPSCs), improved and standardized reprogramming methods and large-scale collections of hiPSC lines are needed, and the stem ce...

Developing Spindlin1 small-molecule inhibitors by using protein microarrays

Single-molecule analysis of ligand efficacy in β2AR–G-protein activation

Single-molecule FRET imaging provides insights into the allosteric link between the ligand-binding and G-protein nucleotide-binding pockets of the β2 adrenergic receptor (β2AR) and improved understa...

Medical News Today: How a small molecule can induce UV-free tanning

Researchers used a small molecule to darken cultured human skin while bypassing sun exposure and the damage caused by ultraviolet rays.

C4 Therapeutics, Calico partnered on targeted protein degradation therapeutics

C4 Therapeutics (C4T) and Calico have announced a five-year collaboration to discover, develop and commercialize therapies for treating diseases of aging, including cancer. Under the terms of the agre...

Using Sugars to Target Triple-Negative Breast Tumors

Researchers at the University of Illinois and collaborators in China have found a way to tag and target elusive cancers with small-molecule sugars by hijacking a cancer cell’s own metabolism.

Pfizer partners with HitGen on small-molecule discovery

HitGen will use its technology to synthesize, design and screen proprietary DNA-encoded libraries to discover small-molecule  -More- 

Matching PubMed Articles

Single-molecule protein identification by sub-nanopore sensors.

Recent advances in top-down mass spectrometry enabled identification of intact proteins, but this technology still faces challenges. For example, top-down mass spectrometry suffers from a lack of sens...

Targeted protein knockdown using small molecule degraders.

Small molecule probes of biological systems have traditionally been designed to bind to and inhibit the active sites of their protein targets. While this class of pharmacological agents has been broad...

Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly.

Domain swapping is the process by which identical proteins exchange reciprocal segments to generate dimers. Here we introduce induced domain swapping (INDOS) as a mechanism for regulating protein func...

Development of a small hybrid molecule that mediates degradation of His-tag fused proteins.

In recent years, the induction of target-protein degradation via the ubiquitin-proteasome system (UPS) mediated by small molecules has attracted attention, and this approach has applications in pharma...

Small-molecule control of protein function through Staudinger reduction.

Using small molecules to control the function of proteins in live cells with complete specificity is highly desirable, but challenging. Here we report a small-molecule switch that can be used to contr...

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