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Search Results for "Target Identification Protein Small Molecule"

07:47 EDT 26th April 2017 | BioPortfolio

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Non-kinase targets of protein kinase inhibitors

Inhibition of proteins other than the intended target by small molecules can lead to the incorrect assignment of biological functions to particular proteins and wasted drug development efforts. Potent...

Induced protein degradation: an emerging drug discovery paradigm

Small-molecule drug discovery has traditionally focused on occupancy of a binding site that directly affects protein function. This article discusses emerging technologies, such as proteolysis-targeti...

Omeros’ Proprietary Orphan GPCR Program Delivers New Target and Approach in Cancer Immunotherapy

Monday, December 5th 2016 at 12:00pm UTC — Small-Molecule Inhibitors Enhance Immune System and May Offer Advantages over Existing Cancer Therapies — SEATTLE–(BUSINESS WIRE)– Om...

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity

The authors developed small-molecule inhibitors of STOML3 oligomerization, a membrane protein that interacts with mechanosensitive ion channels, such as Piezo2. One of these molecules was effective in...

Omeros’ Proprietary Orphan GPCR Program Delivers New Target and Approach in Cancer Immunotherapy

-- Small-Molecule Inhibitors Enhance Immune System and May Offer Advantages over Existing Cancer Therapies -- SEATTLE--(BUSINESS WIRE)--Dec. 5, 2016-- Omeros Corporation (NASDAQ: ...

Identification of small molecule drugs that could benefit from a synbio-based manufacturing process

SOURCE Synthetic biology has been recognized as one of the most promising technologies that may impact our future and I, […]

Preclinical activity of CPI-0610, a novel small-molecule bromodomain and extra-terminal protein inhibitor in the therapy of multiple myeloma

Pfizer partners with HitGen on small-molecule discovery

HitGen will use its technology to synthesize, design and screen proprietary DNA-encoded libraries to discover small-molecule  -More- 

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Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly.

Domain swapping is the process by which identical proteins exchange reciprocal segments to generate dimers. Here we introduce induced domain swapping (INDOS) as a mechanism for regulating protein func...

Selectivity determination of a small molecule chemical probe using protein microarray and affinity capture techniques.

Small molecule selectivity is an essential component of candidate drug selection and target validation. New technologies are required to better understand off-target effects, with particular emphasis ...

Recent Advances in Computational Models for the Study of Protein-Peptide Interactions.

We review computational models and software tools in current use for the study of protein-peptide interactions. Peptides and peptide derivatives are growing in interest as therapeutic agents to target...

Small-molecule control of protein function through Staudinger reduction.

Using small molecules to control the function of proteins in live cells with complete specificity is highly desirable, but challenging. Here we report a small-molecule switch that can be used to contr...

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit.

A hypoxic state is critical to the metastatic and invasive characteristics of cancer. Numerous pathways play critical roles in cancer maintenance, many of which include noncoding RNAs such as microRNA...

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