Search Results for "Target Identification Protein Small Molecule"

00:16 EDT 2nd August 2015 | BioPortfolio

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Hybrigenics Corp

Hybrigenics Services was founded on its optimized ULTImate Y2H™ technologies enabling the identification of protein binding partners of any protein (i.e., soluble, membrane-bound, post-translational...

Small molecule could pave way for novel vaccine adjuvants

Identification and characterisation of a small molecule that targets protein receptors that stimulate the immune system could lead to novel vaccine adjuvants and anti-tumour agents.

Small molecule–triggered Cas9 protein with improved genome-editing specificity

Directly modulating the activity of genome-editing proteins has the potential to increase their specificity by reducing activity following target locus modification. We developed Cas9 nucleases that a...

New Developments in Characterizing Protein-Small Molecule Interactions for Drug Discovery

Isothermal titration calorimetry (ITC) is a highly valuable technique that is used throughout drug discovery workflow to study the binding interactions of proteins and small molecules. It is an essent...

PROTAC Goes Small-Molecule

Since I mentioned the Bradner lab's protein-destruction technology recently, I should also highlight this recent paper from Craig Crews and co-workers. In that post, I noted that their PROTAC method h...

Know your target, know your molecule

The pharmaceutical industry continues to experience significant attrition of drug candidates during phase 2 proof-of-concept clinical studies. We describe some questions about the characteristics of p...

Alliance Pharma

Alliance Pharma is a Contract Research Organization (CRO) specializing in Drug Metabolism and Pharmacokinetic (DMPK) and bioanalytical services for both small and large molecules. Our extensive and di...

Epigenetics: Disrupting histone lysine methylation

A small molecule targeting the protein-protein interaction between a chromatin binding protein and an oncogenic transcription factor shows therapeutic potential in a subtype of acute myeloid leukemia.

Matching PubMed Articles

Design of High Throughput Screening Assays and Identification of a SUMO1-Specific Small Molecule Chemotype Targeting the SUMO-Interacting Motif-Binding Surface.

Protein-protein interactions are generally challenging to target by small molecules. To address the challenge, we have used a multi-disciplinary approach to identify small-molecule disruptors of prote...

Substrate Pathways in the Nitrogenase MoFe Protein by Experimental Identification of Small Molecule Binding Sites.

In the nitrogenase molybdenum-iron (MoFe) protein, we have identified five potential substrate access pathways from the protein surface to the FeMo-cofactor (the active site) or the P-cluster using ex...

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL-2 family inhibitors such as ABT-263 (navitoclax), making it an attracti...

Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery.

Heat shock protein 90 (Hsp90) is an adenosine triphosphate dependent molecular chaperone in eukaryotic cells that regulates the activation and maintenance of numerous regulatory and signaling proteins...

HIF-1α suppressing small molecule, LW6, inhibits cancer cell growth by binding to calcineurin b homologous protein 1.

Hypoxia inducible factor-1 alpha (HIF-1α) plays an important role in angiogenesis and metastasis and is a promising therapeutic target for the development of anti-cancer drugs. We recently developed ...

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