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Search Results for "Target Identification Protein Small Molecule"

23:38 EST 12th February 2016 | BioPortfolio

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Single-molecule localization techniques provide high spatial resolution in protein labeling

Protein labeling with synthetic fluorescent probes is a key technology in chemical biology and biomedical research. The target proximity achieved by small-molecule probes is essential to exploit the f...

Selective small-molecule inhibition of an RNA structural element

A novel drug, ribocil, is shown to mimic the binding of a natural ligand to a bacterial riboflavin riboswitch (a non-coding stretch of messenger RNA whose structure is affected by a ligand—usually o...

Regen BioPharma Initiates Small Molecule Hit Validation Study On Cancer Stem Cell Target Gene

SAN DIEGO, September 23, 2015 /PRNewswire/ --Regen BioPharma Inc. (OTCBB: RGBP) and (OTC PINK: RGBP) announced today that it has initiated studies for its small molecule drug discovery platform on its...

Celgene, Nurix Target Protein Homeostasis for Next-Gen Therapies\n

To develop small molecule therapeutics in oncology, inflammation and immunology

Figure: Binding SMART

Warp's independence day Binding SMART Warp Drive Bio LLC's Small Molecule Assisted Receptor Targeting (SMART) technology allows a small molecule to inhibit intracellular protein-protein interactions b...

Small protein engineered to target PD-L1 is more potent than anti-PD-L1 antibody immunotherapeutic

An engineered high-affinity PD-1 small protein that can bind to PD-L1 on tumours was found to be a more effective anticancer immunotherapeutic than conventional anti- PD-L1 antibodies, and this small ...

Methods: A small-molecule SMASh hit

There are many techniques that can be employed to control gene expression at the post-translational level. However, a novel system called SMASh (small molecule–assisted shutoff), which allows for ch...

Promega NanoLuc NanoBRET target engagement technology

Promega NanoLuc technology has been used to directly assess the dynamic process of target engagement in live cancer cells. The company’s scientists have developed a method for use in drug discovery ...

Matching PubMed Articles

An in solution assay for interrogation of affinity and rational minimer design for small molecule-binding aptamers.

Aptamers are short single-stranded oligonucleotides that fold into unique three-dimensional structures, facilitating selective and high affinity binding to their cognate targets. It is not well unders...

Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.

The HIV-1 CA protein is an attractive therapeutic target for the development of new antivirals. An inter-protomer pocket within the hexamer configuration of the CA, which is a binding site for key hos...

Restored physiology in protein-deficient yeast by a small molecule channel.

Deficiencies of protein ion channels underlie many currently incurable human diseases. Robust networks of pumps and channels are usually responsible for the directional movement of specific ions in or...

Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors.

Application of safety lead optimization screening strategies during the early stage of drug discovery led to the identification of a series of CNS-active small molecule inhibitors with opioid off-targ...

SPLINTS: small-molecule protein ligand interface stabilizers.

Regulatory protein-protein interactions are ubiquitous in biology, and small molecule protein-protein interaction inhibitors are an important focus in drug discovery. Remarkably little attention has b...

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