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Search Results for "Target Identification Protein Small Molecule"

21:24 EDT 1st May 2016 | BioPortfolio

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

The biological rationale for targeting protein–protein interactions as a therapeutic strategy is strong, but identifying viable small-molecule drugs to achieve this has proved highly challenging. Th...

Sanofi, DiCE form discovery collaboration

Sanofi (Euronext:SAN; NYSE:SNY) and DiCE Molecules SV LLC (Redwood City, Calif.) entered a five-year collaboration on Wednesday to co-develop small molecules against up to 12 targets using DiCE's smal...

Figure: Binding SMART

Warp's independence day Binding SMART Warp Drive Bio LLC's Small Molecule Assisted Receptor Targeting (SMART) technology allows a small molecule to inhibit intracellular protein-protein interactions b...

Small molecule slows down ticking of the biological clock

A group of biologists, theoretical chemists and synthetic chemists at ITbM have come together to develop a small molecule that slows down the circadian clock rhythm through binding to the CRY clock pr...

Promega NanoLuc NanoBRET target engagement technology

Promega NanoLuc technology has been used to directly assess the dynamic process of target engagement in live cancer cells. The company’s scientists have developed a method for use in drug discovery ...

Light-assisted small-molecule screening against protein kinases

High-throughput live-cell screens are intricate elements of systems biology studies and drug discovery pipelines. Here, we demonstrate an optogenetics-assisted method that avoids the need for chemical...

Vanquish Oncology’s small molecule could trigger selective cancer cell death

The drug works by activating a protein called procaspase-3 that triggers

Teva Backs Small Molecule CGPR Approach To Migraine With Heptares Deal

"CGRP is a well validated target for migraine but getting good small molecules for it have proved difficult because it's a difficult target to 'drug'. Our structure-based drug design approach has had ...

Matching PubMed Articles

An in solution assay for interrogation of affinity and rational minimer design for small molecule-binding aptamers.

Aptamers are short single-stranded oligonucleotides that fold into unique three-dimensional structures, facilitating selective and high affinity binding to their cognate targets. It is not well unders...

Identification of a small molecule HIV-1 inhibitor that targets the capsid hexamer.

The HIV-1 CA protein is an attractive therapeutic target for the development of new antivirals. An inter-protomer pocket within the hexamer configuration of the CA, which is a binding site for key hos...

Restored physiology in protein-deficient yeast by a small molecule channel.

Deficiencies of protein ion channels underlie many currently incurable human diseases. Robust networks of pumps and channels are usually responsible for the directional movement of specific ions in or...

Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors.

Application of safety lead optimization screening strategies during the early stage of drug discovery led to the identification of a series of CNS-active small molecule inhibitors with opioid off-targ...

SPLINTS: small-molecule protein ligand interface stabilizers.

Regulatory protein-protein interactions are ubiquitous in biology, and small molecule protein-protein interaction inhibitors are an important focus in drug discovery. Remarkably little attention has b...

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