Search Results for "Target Identification Protein Small Molecule"
Original Source: Identification of direct protein targets of small molecules.
Small-molecule target identification is a vital and daunting task for the chemical biology community as well as for researchers interested in applying the power of chemical genetics to impact biology and medicine. To overcome this "target ID" bottleneck, new technologies are being developed that analyze protein-drug interactions, such as drug affinity responsive target stability (DARTS), which aims to discover the direct binding targets (and off targets) of small molecules on a proteome scale without requir...
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p53 - protein 53 - tumor protein 53
The p53 molecule is centrally important to the apoptosis pathway, and found in many cell pathways leading to apoptosis. As a tumour suppressor protein, its downstream compounds act to prevent apopto...
Human Epidermal Growth Factor receptor EGF R
The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...
MAP kinase kinase MEK Inhibitors
The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death. The MAPK pathway has emerged as the crucial route between membrane-bound Ras...
Bcr Abl and Src Kinase Inhibitors
Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...
Epithelial cell adhesion molecule EpCAM CD326
Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian,...
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Molecular biology: Small RNA tunes protein
A small RNA molecule that controls whether bacteria coalesce into biofilms has a surprising mode of action.Small RNAs are known to regulate gene expression by binding to target messenger RNAs, typical...
Allosteric control of the ribosome by small-molecule antibiotics
Antibiotics target protein synthesis by binding and inhibiting key functional centers of the ribosome. Single-molecule imaging and X-ray crystallography studies now demonstrate that the aminoglycoside...
Small molecule disrupts cancer-causing protein
Researchers have developed a small molecule that inhibits STAT3, a protein that causes cancer. This development could impact the treatment of several tumor types, including breast, lung, prostate and...
Priaxon, GSK sign research collaboration on protein-protein-interactions
Priaxon has signed research collaboration with GlaxoSmithKline (GSK) to develop small molecule modulators for various protein-protein-interactions (PPIs).
Moffitt Cancer Center researchers design small molecule to disrupt cancer-causing protein
(H. Lee Moffitt Cancer Center & Research Institute) Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have developed a small molecule that inhibits STAT3, a protei...
Investigational Brain Cancer Vaccine To Be Tested In Phase I Roswell Park Study
A new clinical research study at Roswell Park Cancer Institute (RPCI) will test a first-of-its-kind cancer "vaccine" that may prove effective against many forms of solid-tumor cancers. The vaccine, to...
Nuevolution raises €11 million in new financing round
Danish small-molecule lead discovery company Nuevolution has raised DKK 80.5 million (€10.8 million) in a new financing round. The round was led by Industrifonden with support from existing investor...
TWi Biotechnology sees hints of success in anti-inflammatory approach to type 2 diabetes
The Taiwanese company TWi Biotechnology is having some success with an oral small-molecule IL-1beta inhibitor in the treatment of type 2 diabetes, Phase IIb data suggest. The product is the leading sm...
Matching PubMed Articles
Identification of direct protein targets of small molecules.
Small-molecule target identification is a vital and daunting task for the chemical biology community as well as for researchers interested in applying the power of chemical genetics to impact biology...
Target identification for small bioactive molecules: finding the needle in the haystack.
Identification and confirmation of bioactive small-molecule targets is a crucial, often decisive step both in academic and pharmaceutical research. Through the development and availability of several...
Identifying the Cellular Targets of Bioactive Small Molecules with Activity-Based Probes.
The renaissance of cell- or organism-based phenotypic assays has made subsequent target identification for bioactive small organic molecules an important aspect of current drug discovery. Among the ma...
An in silico structure-based ligand design approach resulted in the identification of the first non-peptidic small molecule able to inhibit protein-protein interactions between 14-3-3 and c-Abl. This...
Small-Molecule Inhibitors of IL-2/IL-2R: Lessons Learned and Applied.
The IL-2:IL-2R protein-protein interaction is of central importance to both healthy and diseased immune responses, and is one of the earliest examples of successful small-molecule inhibitor discovery...
