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Search Results for "Target Identification Protein Small Molecule"

17:16 EST 10th December 2016 | BioPortfolio

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Human Epidermal Growth Factor receptor EGF R

The human epidermal growth factor receptor (HER) family members include EGFR (erbB1), HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4) that are structurally related, and all except HER3 contain intr...

MAP kinase kinase MEK Inhibitors

The mitogen activated protein kinases (MAPKs) are conserved proteins that regulate cell growth, division and death.  The MAPK pathway has emerged as the crucial route between membrane-bound Ras...

Bcr Abl and Src Kinase Inhibitors

Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a reciprocal translocation between the long arms of the chromosomes 9 and 22 t...

Epithelial cell adhesion molecule EpCAM CD326

Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, ...

PolyXen

PolyXen® is an enabling technology for protein drug delivery.  It uses the natural polymer polysialic acid (PSA) to prolong the active life and improve the stability of therapeutic peptides...

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Small-molecule control of protein function through Staudinger reduction

A generally applicable small-molecule switch for protein function in live cells has been developed based on selective protein protection using unnatural amino acid mutagenesis and a bioorthogonal depr...

Targeting RNA-Binding Proteins

An RNA-binding protein fused with the catalytic domain of an RNA-editing enzyme makes for easier identification of the binding protein's target—a boon for studying gene expression and cellular f...

Proteome-wide covalent ligand discovery in native biological systems

Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes...

Induced protein degradation: an emerging drug discovery paradigm

Small-molecule drug discovery has traditionally focused on occupancy of a binding site that directly affects protein function. This article discusses emerging technologies, such as proteolysis-targeti...

Omeros’ Proprietary Orphan GPCR Program Delivers New Target and Approach in Cancer Immunotherapy

Monday, December 5th 2016 at 12:00pm UTC — Small-Molecule Inhibitors Enhance Immune System and May Offer Advantages over Existing Cancer Therapies — SEATTLE–(BUSINESS WIRE)– Om...

Cantabio signs deal with PRF to advance development work on targeting DJ-1 protein small molecule pharmaceutical chaperone drug candidates

Cantabio Pharmaceuticals has signed an agreement with Purdue Research Foundation (PRF) to advance the company’s development work on targeting DJ-1 protein small molecule pharmaceutical chaperone dru...

MAb characterisation course could reskill small molecule API workers, NIBRT

Interested in moving from small to large molecule manufacturing? An upcoming course will address mAb characterisation challenges and offer hands-on experience for small molecule manufacturers , says N...

Omeros’ Proprietary Orphan GPCR Program Delivers New Target and Approach in Cancer Immunotherapy

-- Small-Molecule Inhibitors Enhance Immune System and May Offer Advantages over Existing Cancer Therapies -- SEATTLE--(BUSINESS WIRE)--Dec. 5, 2016-- Omeros Corporation (NASDAQ: ...

Matching PubMed Articles

SPLINTS: small-molecule protein ligand interface stabilizers.

Regulatory protein-protein interactions are ubiquitous in biology, and small molecule protein-protein interaction inhibitors are an important focus in drug discovery. Remarkably little attention has b...

Selectivity determination of a small molecule chemical probe using protein microarray and affinity capture techniques.

Small molecule selectivity is an essential component of candidate drug selection and target validation. New technologies are required to better understand off-target effects, with particular emphasis ...

Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin.

15-Deoxyspergualin (DSG) is an immunosuppressive agent being clinically used. Unlike tacrolimus and cyclosporine A, it does not inhibit the calcineurin pathway, and its mechanism of action and target ...

Target identification of natural and traditional medicines with quantitative chemical proteomics approaches.

Natural and traditional medicines, being a great source of drugs and drug leads, have regained wide interests due to the limited success of high-throughput screening of compound libraries in the past ...

Recent Advances in Computational Models for the Study of Protein-Peptide Interactions.

We review computational models and software tools in current use for the study of protein-peptide interactions. Peptides and peptide derivatives are growing in interest as therapeutic agents to target...

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