Search Results for "Targeting Apoptosis Fibroblast On Keloid"
Original Source: Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts.
Keloid, a fibro-proliferative benign tumor of skin, is characterized by an enriched milieu of growth factors and an abundant accumulation of extracellular matrix (ECM). Transforming growth factor (TGF)-β1 is well known as the crucial fibrogenic cytokine promoting ECM production and tissue fibrosis in keloid forming. Epigenetic modifications have been shown to play a role in the pathogenesis of cancer as well as autoimmune and inflammatory disorders. Recent publication reports epigenetic modifications in ke...
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Fibroblast Growth Factors FGFs
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development. Quite a number of FGF-R ag...
Ras is the first protein in the apoptosis cascade
Ras is the first protein in the apoptosis cascade, activated by tyrosine kinase receptors in response to growth factor stimulation from the extra cellular matrix. Ras is an oncogene, meaning it prom...
p53 - protein 53 - tumor protein 53
The p53 molecule is centrally important to the apoptosis pathway, and found in many cell pathways leading to apoptosis. As a tumour suppressor protein, its downstream compounds act to prevent apopto...
Although the human cytokines interleukin-2 (IL-2) and tumor necrosis factor (TNF) alpha are approved marketed for tumor therapy, their use is rather limited due to severe systemic side effects. Targ...
The Ras-Raf-MEK-ERK (ERK) pathway is a logical therapeutic target because it represents a common downstream pathway for several key growth factor tyrosine kinase receptors which are often mutated or...
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Drug companies, universities unite in new drug development
Drug companies are partnering with universities to develop drugs, and are even recruiting academic scientists. -More- New Apoptosis-Targeting Drug Gets B Cells, Spares Platelets Researchers...
Targeting microRNAs to modulate TRAIL-induced apoptosis of cancer cells
New Substance Has Potential To Induce Apoptosis In Cancer Cells
The p53 gene plays a key role in the prevention of cancer, by blocking cell growth and triggering programmed cell death or apoptosis. If, however, p53 has mutated and become defective, the cancer cell...
Scientists find new way to induce programmed cell death, or apoptosis
(The Hebrew University of Jerusalem) Researchers from the Hebrew University and Weizmann Institute have developed a technique to cause apoptosis -- programmed cell death. In two proteins involved in a...
APR-246 can restore function of defective p53 and activate apoptosis in cancer cells
The p53 gene plays a key role in the prevention of cancer, by blocking cell growth and triggering programmed cell death or apoptosis. If, however, p53 has mutated and become defective, the cancer cell...
Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation
Matching PubMed Articles
Pirfenidone suppresses keloid fibroblast-embedded collagen gel contraction.
Keloid is a clinically intractable disease that causes disfigurement, itching, and pain due to abnormal proliferation of fibroblasts and production of collagen. Pirfenidone is a novel anti-fibrotic ag...
Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts.
Keloid, a fibro-proliferative benign tumor of skin, is characterized by an enriched milieu of growth factors and an abundant accumulation of extracellular matrix (ECM). Transforming growth factor (TGF...
Low-dose 5-fluorouracil induces cell cycle G2 arrest and apoptosis in keloid fibroblasts.
Summary Background Intralesional injection of low-dose 5-fluorouracil (5-FU) has recently been used as an experimental modality for treating keloid scarring and shown promising efficacy in improving s...
Background: Keloid scarring is a dermal fibroproliferative disorder characterized by increased fibroblast proliferation and excessive production of collagen-extracellular matrix (ECM) components. T...
Keloid is a dermal fibroproliferative growth that results from dysfunction of the wound healing processes. Through a multistage genome-wide association study using 824 individuals with keloid (cases)...
