Search Results for "Targeting Integrins In Malignant"
Original Source: Targeting integrins in malignant glioma.
The integrin family of cell adhesion receptors is emerging as a promising target of anticancer therapy. AlphaVbeta3 and alphaVbeta5 integrins are overexpressed on both glioma cells and tumor vasculature. Cilengitide, the most advanced specific integrin inhibitor in oncology, has shown antitumor activity against glioma in early clinical trials. Durable remissions have been observed in phase I and phase II trials for recurrent glioblastoma (GBM) with both lower and higher doses of cilengitide. Pilot trials in...
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Unanchoring integrins in focal adhesions
Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics now indicates that...
Targeting integrins to promote bone formation and repair
Age-related bone loss can eventually result in osteoporosis. In this Review, Pierre Marie describes an emerging therapy that involves targeting certain integrin transmembrane proteins to promote the d...
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
Giannone and colleagues use super-resolution microscopy to analyse the nanoscale dynamic organization of talin and integrins β1 and β3 in focal adhesions.
Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail
Integrin internalization through the endosomal pathway can lead either to recycling back to the surface or to lysosomal degradation. Faessler and colleagues now show that, following internalization, Î...
Got to go? Scientists figure out how you know
Help is on the way for overactive bladder or incontinence. According to new research the epithelium, a layer of cells lining the bladder's surface, senses bladder fullness through proteins called inte...
If you have an overactive bladder or incontinence, help could be on the way. A new research report published online in the The FASEB Journal, shows that the epithelium, a thin layer of cells which lin...
Got to go? Harvard scientists figure out how you know
(Federation of American Societies for Experimental Biology) Help is on the way for overactive bladder or incontinence. According to research published in the FASEB Journal, the epithelium, a layer of...
Peptides and Their Utility in Modulation of Behavior of Cells Expressing alpha3beta1 Integrins
The present invention relates generally to peptides that bind to or are recognized by alpha3beta1 integrins and in particular, to pharmaceutical compositions containing and methods of using said pepti...
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Targeting integrins in hepatocellular carcinoma.
Introduction: Integrins, which are heterodimeric membrane glycoproteins, consist of a family of cell-surface receptors mediating cell-matrix and cell-cell adhesion. Analysis of tumor-associated integr...
Integrin signaling critically contributes to the progression, growth, and therapy resistance of malignant tumors. Here, we show that targeting of β1 integrins with inhibitory antibodies enhances the...
αv-Integrin isoform expression in primary human tumors and brain metastases.
PURPOSE: To determine whether metastasis to brain is associated with altered expression patterns of integrins, we investigated the expression of αvβ3, αvβ5, αvβ6 and αvβ8 integrins in primary...
Targeting integrins in malignant glioma.
The integrin family of cell adhesion receptors is emerging as a promising target of anticancer therapy. AlphaVbeta3 and alphaVbeta5 integrins are overexpressed on both glioma cells and tumor vasculatu...
INTRODUCTION:: This study investigates the expression and the clinical significance of Lewis y and integrins α5 and β1 in serous and mucinous ovarian tumors and then evaluates the association betwee...
