Angiotensin inhibition

Tissue Growth Factors BMP 2

The classical tissue factors typically are proteins used for tissue repair and growth stimulation. Among the approved products are the growth factors PDGF, IGF, EGF, BMP and FGF. One of the commercial...

Transforming growth factor beta TGF beta

Transforming growth factor-beta (TGF-beta) family members are secreted multifunctional cytokines that play pivotal roles in development and disease. The prototypic member of this family, TGF-beta, pla...

Growth hormone GH

Tumor Growth and Metastasis

Individualized Cancer Therapy that Suppresses Tumor Progression and Metastasis Through Decreased Expression of TGF-beta Receptor II in Bone Marrow Derived Cells

Scientists at the NIH have developed a method of suppressing tumor progression and metastasis by targeting a pathway. This novel treatment method is an individualized therapy that first screens patien...

The AAPS Journal: Interactions of Everolimus and Sorafenib in Pancreatic Cancer Cells

Type: Original PaperEverolimus targets the mammalian target of rapamycin, a kinase that promotes cell growth and proliferation in pancreatic cancer. Sorafenib inhibits the Raf-mitogen-activated protei...

[Comment] IGF-1R inhibition: right direction, wrong pathway?

Inhibition of oestrogen receptor is a mainstay of treatment for oestrogen-receptor-positive breast cancer. Unfortunately, intrinsic and acquired resistance undermine the long-term effectiveness of end...

PDGFR blockade is a rational and effective therapy for NPM-ALK–driven lymphomas

Anaplastic large cell lymphomas (ALCL) often express the oncoprotein NPM-ALK. This study shows that the activator protein 1 family members JUN and JUNB promote lymphoma development through platelet-de...

Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

NRAS-driven melanomas have limited therapeutic options. Combining genetically engineered models and oncogenic signaling inhibitors with rational systems-biology approaches, the authors compare the eff...

VEGF Inhibition Via TGF-B1 Suggested For Glaucoma Surgery

The most common cause of failure after glaucoma surgery is scarring at the surgical site, so researchers are actively looking for ways to minimize or prevent scar formation. Previous work had suggeste...

Inhibition of FOXM1 transcription factor suppresses cell proliferation and tumor growth of breast cancer

Inhibition of the Stem Cell Marker Nestin Reduces Tumor Growth and Invasion of Malignant Melanoma

Hyaluronan synthesis mediates the fibrotic response of keratocytes to transforming growth factor beta.

Transforming growth factor beta (TGFbeta) induces fibrosis in healing corneal wounds, and in vitro, corneal keratocytes upregulate expression of several fibrosis-related genes in response to TGFbeta....

TGFbeta signaling in head and neck squamous cell carcinoma.

Transforming growth factor beta (TGFbeta) is a key regulator of epithelial cell proliferation, immune function and angiogenesis. Because TGFbeta signaling maintains epithelial homeostasis, dysregulate...

Role of Transforming Growth Factor Beta in Corneal Function, Biology and Pathology.

Transforming growth factor-beta (TGFbeta) is a pleiotropic multifunctional cytokine that regulates several essential cellular processes in many parts of the body including the cornea. Three isoforms o...

Resistance to Transforming Growth Factor-{beta}-mediated tumor suppression in melanoma: Are multiple mechanisms in place?

Resistance to Transforming Growth Factor beta (TGFbeta)-mediated tumor suppression in melanoma appears to be a crucial step in tumor aggressiveness, since it is usually coupled with the ability of TGF...

Inhibition of JNK enhances chondrogenesis of mesenchymal progenitor cells by increasing autocrine TGFbeta signaling.

OBJECTIVE.: To establish the role and mechanism of action of c-Jun N-terminal kinase in chondrogenic differentiation of mesenchymal progenitor cells. METHODS.: Chondrogenic differentiation of human me...