Vascular Dementia

Vascular Dementia accounts for 25% of all dementias (the second most commen cause after Alzheimers. It is the cumulative effects of many small strokes - patients often have evidence of vascular path...

Crohns Disease

Crohns Disease is a chronic inflammatory disease, affecting the whole of the alimentary tract from mouth to anus, and all layers of the gut wall. The most commonly affected sites are the terminal il...

Alzheimer's Disease

Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles'...

BioPortfolio Twitter Accounts

BioPortfolio has created a number of Twitter accounts to help you keep upto date on the latest news, research papers, reports and clinical trials on a selected range of important and popular topics....

Caspase Pathways

Caspases are a family of enzymes with very specific characteristics that can be used in almost every biological pathway in the body. The knock-on effects of the action of caspases keep us alive, ini...

Human medicines European Public Assessment Report (EPAR): Thalidomide Celgene (previously Thalidomide Pharmion), thalidomide, Revision: 11, Authorised

Human medicines European Public Assessment Report (EPAR): Thalidomide Celgene (previously Thalidomide Pharmion), thalidomide, Revision: 13, Authorised

Human medicines European Public Assessment Report (EPAR): Thalidomide Celgene (previously Thalidomide Pharmion), thalidomide, Revision: 12, Authorised

Human medicines European Public Assessment Report (EPAR): Thalidomide Celgene (previously Thalidomide Pharmion), thalidomide, Revision: 14, Authorised

Thalidomide survivors to get £80m grant

The government has set aside £80m to meet the health needs of 325 Thalidomide victims in England over the next decade. It will support them as they approach old age and be paid to the Thalidomid...

Thalidomide Apology 50 Years Later

Gruenenthal Group's CRO has apologized to mothers who took Thalidomide in the 1950s and 1960s and gave birth to children with congenital birth defects. Exactly 50 years ago today, Thalidomide was pull...

Alzheimers Can Strike Earlier than Expected

Alzheimers can develop much sooner than some might expect; catching it early however can mean a longer life.

#SciAmBlogs Thursday - Thalidomide, coral guards, tool-using cockatoo, carnivorous harp sponge, last Ethiopian wolves, and more.

- Judy Stone - From the Holocaust to Thalidomide: A Nazi Legacy   [More]

Teratogenic effects of thalidomide: molecular mechanisms.

Fifty years ago, prescription of the sedative thalidomide caused a worldwide epidemic of multiple birth defects. The drug is now used in the treatment of leprosy and multiple myeloma. However, its use...

Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin analogue.

Herein we describe the synthesis of the first Thalidomide-biotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the a...

In Vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice.

In vivo drug interactions of the teratogen thalidomide with the model cytochrome P450 (P450) 3A substrate midazolam were investigated in mice with humanized livers. The clearance of midazolam (adminis...

Metabolism of thalidomide by human liver microsome cytochrome CYP2C19 is required for its antimyeloma and antiangiogenic activities in vitro.

In this study, we used a system of human liver microsomes to investigate the antimyeloma and antiangiogenic activities of thalidomide. Myeloma cells and human umbilical vein endothelial cells (HUVECs)...

Lessons of Leprosy: The Emergence of TH17 Cytokines During Type II Reactions (ENL) Is Teaching Us About T-cell Plasticity.

Background: Leprosy was the first disease classified according to the thymus derived T-cell in the 1960s and the first disease classified by the cytokine profile as intact interferon- (IFN-γ) an...