Arteriovenous Malformations

Congenital malformations

Lymphatic Malformations

Crohns Disease

Crohns Disease is a chronic inflammatory disease, affecting the whole of the alimentary tract from mouth to anus, and all layers of the gut wall. The most commonly affected sites are the terminal il...

Human medicines European Public Assessment Report (EPAR): Thalidomide Celgene (previously Thalidomide Pharmion), thalidomide, Revision: 13, Authorised

Human medicines European Public Assessment Report (EPAR): Thalidomide Celgene (previously Thalidomide Pharmion), thalidomide, Revision: 12, Authorised

Human medicines European Public Assessment Report (EPAR): Thalidomide Celgene (previously Thalidomide Pharmion), thalidomide, Revision: 11, Authorised

Thalidomide survivors to get £80m grant

The government has set aside £80m to meet the health needs of 325 Thalidomide victims in England over the next decade. It will support them as they approach old age and be paid to the Thalidomid...

Thalidomide Apology 50 Years Later

Gruenenthal Group's CRO has apologized to mothers who took Thalidomide in the 1950s and 1960s and gave birth to children with congenital birth defects. Exactly 50 years ago today, Thalidomide was pull...

Pregnancy May Raise Risk of Cerebral Bleeding in Some Women

TUESDAY, Aug. 14 (HealthDay News) -- Pregnant women are at higher risk of bleeding in the brain from vessel abnormalities known as arteriovenous malformations, a new study indicates. Arteriovenous ma...

#SciAmBlogs Thursday - Thalidomide, coral guards, tool-using cockatoo, carnivorous harp sponge, last Ethiopian wolves, and more.

- Judy Stone - From the Holocaust to Thalidomide: A Nazi Legacy   [More]

100-Plus Aussies, Kiwis Get Chance For Diageo Thalidomide Settlements

More than 100 New Zealanders and Australians have been advised they, too, will be invited to discuss settlements of thalidomide suits against U.K. drug distributor Diageo in the wake of its first out-...

The thalidomide experience: review of its effects 50 years later.

This year is the 50(th) anniversary of the discovery that the drug thalidomide causes birth defects and should therefore be considered as a teratogen. However, despite the existence of several other d...

Teratogenic effects of thalidomide: molecular mechanisms.

Fifty years ago, prescription of the sedative thalidomide caused a worldwide epidemic of multiple birth defects. The drug is now used in the treatment of leprosy and multiple myeloma. However, its use...

Redox-stimulation of cardiomyogenesis versus inhibition of vasculogenesis upon treatment of mouse embryonic stem cells with thalidomide.

Thalidomide (-(N-phthalimido)-glutarimide) exerts anti-angiogenic properties and causes cardiac malformations in embryos. Herein the effects of thalidomide on cardiovascular differentiation were inves...

The role of HIF-1, angiopoietin-2, Dll4 and Notch1 in bleeding gastrointestinal vascular malformations and thalidomide-associated actions: A pilot in vivo study.

  To investigate plasma levels of hypoxia inducible factor-1 (HIF-1), angiopoietin-2 (Ang-2), Delta-like ligand 4 (Dll4) and Notch1 in patients with recurrent gastrointestinal bleeding due to gastro...

Managing the teratogenic risk of thalidomide and lenalidomide: an industry perspective.

Celgene has developed and operated pregnancy prevention programs since 1998 with the first approval of thalidomide in the US. With the development and marketing of lenalidomide, an analog of thalidomi...