Thimerosal Preservative

Thimerosal is a mercury-based preservative that has been used for decades in the United States in multi-dose vials (vials containing more than one dose) of some vaccines to prevent the growth of ger...

Kadcyla (ado-trastuzumab emtansine)

Kadcyla™ (ado-trastuzumab emtansine or T-DM1) for the treatment of people with HER2-positive metastatic breast cancer (mBC) who have received prior treatment with Herceptin® (trastuzumab)...

Prostate Cancer

Prostate cancer is the most common cancer in men in the UK; affecting 250,000 men. Risk factors for prostate cancer include age (average age at diagnosis is 70), a family history and a Caribbean or...

Anthrax Vaccines and Therapeutics

Anthrax is a zoonotic disease caused by the spore-forming bacterium Bacillus anthracis. The disease most commonly occurs in mammals (e.g., cattle, sheep, goats, camels, antelope. Anthrax occurs in hu...

Glybera

uniQure has developed Glybera as a therapy for patients with the genetic disorder lipoprotein lipase deficiency. LPLD is an orphan disease for which no treatment exists today. The disease is caused...

Toshiba CT Enhances Patient Safety with MITA's Smart Dose Standard

BUSINESS WIRE -- As a leader in developing low dose CT technologies, all new Toshiba America Medical Systems, Inc. Aquilion™ CT systems meet the needs of the recently announced Smart Dose s...

GSK introduces metered dose inhaler with dose counter

GlaxoSmithKline (GSK) Pharmaceuticals today announced the launch of an enhanced version of a metered dose inhaler (MDI) with dose counter, for the first time in India.

Innovation Enhances Low-Dose Imaging Procedures

Automated dose monitoring and optimization will help increase patient care by empowering clinicians to reduce and amend dose levels.

Standard-Dose vs High-Dose Multivitamin Supplements for HIV

To the Editor: In the study by Dr Isanaka and colleagues, patients with human immunodeficiency virus (HIV) receiving highly active antiretroviral therapy were treated either with standard-dose or high...

Pharmacists and carers unsure about paracetamol doses for children with obesity

The correct therapeutic dose is important for this commonly used painkiller, say the authors, because it is potentially fatal to give too high a dose; and too low a dose may result in more serious ill...

Repros' Proellex(R)-V Topline Analysis Suggests 12 Mg Dose Effective and Well Tolerated in ...

Company to request end of Phase 2 meeting with FDA during Q1 2013 Consistent efficacy after 4 months of treatment at 12 mg vaginal dose Overall good benefit risk ratio for 12 mg dose...

GE Meets MITA's Smart Dose Standard

GE Healthcare recently announced that all of its new CT products meet the Medical Imaging and Technology Alliance (MITA) smart dose standard that raises the bar for CT dose management. "Delivering...

Standard-Dose vs High-Dose Multivitamin Supplements for HIV—Reply

In Reply: Drs Padayatty and Levine highlight the familiar challenge in selecting doses for trials of multivitamin efficacy and suggest that the null findings in our study of high-dose vs standard-dose...

Theraputic targeting of Trk supresses tumor proliferation and enhances cisplatin activity in HNSCC.

Head and neck squamous cell carcinoma (HNSCC) is a biologically aggressive disease that has been modestly impacted by improvements in therapeutic strategies. Several lines of evidence support the role...

Dose specification for radiation therapy: dose to water or dose to medium?

The Monte Carlo method enables accurate dose calculation for radiation therapy treatment planning and has been implemented in some commercial treatment planning systems. Unlike conventional dose calcu...

Two-stage designs for Phase 2 dose-finding trials.

We propose a Bayesian adaptive two-stage design for the efficient estimation of the maximum dose or the minimum effective dose in a dose-finding trial. The new design allocates subjects in stage two a...

Logarithmic dose transformation in epidemiologic dose-response analysis: Use with caution.

Dose-response models based on the logarithm of dose or exposure are utilized in the analysis of both toxicologic and epidemiologic data. While the applications are similar, fundamental differences in...

Single versus multi-dose vaccine vials: An economic computational model.

Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developer...