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Cerebral Infusion of AAV9 Vector-encoding Non-self Proteins Can Elicit Cell-mediated Immune Responses

AAV9-mediated VEGF-B Gene Transfer Improves Systolic Function in Progressive Left Ventricular Hypertrophy

Application of Mutated miR-206 Target Sites Enables Skeletal Muscle-specific Silencing of Transgene Expression of Cardiotropic AAV9 Vectors

Improved Survival and Reduced Phenotypic Severity Following AAV9/MECP2 Gene Transfer to Neonatal and Juvenile Male Mecp2 Knockout Mice

News and press releases: European Medicines Agency recommends new advice on safer use of fibrin sealant spray applications

The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended a number of new instructions for healthcare professionals using the fibrin sealants Tisseel, Tis...

Families of SMA and Nationwide Children’s Hospital Announce Multi-Million Dollar Award from NINDS

Elk Grove Village, IL, March 20, 2013 --(PR.com)-- This three-year multi-million dollar cooperative agreement to Brian Kaspar, PhD, principal investigator in the Center for Gene Therapy at The Resear...

Gene Therapy Developed for ALS Treatment: New Biotech Company Neuralgene Enters Evaluation Phase

BOGOTA, Colombia, April 12, 2013 /PRNewswire/ -- Startup biotechnology company Neuralgene (http://neuralgene.com) has announced that it will begin animal studies in May to evaluate the effic...

Covidien Launches Three New Hernia Care Products at American Hernia Society Annual Meeting

Covidien (NYSE:COV), a leading global provider of healthcare products, is launching three new hernia care products that address clinical needs in laparoscopic inguinal, ven...

Strong Cortical and Spinal Cord Transduction After AAV7 and AAV9 Delivery Into the Cerebrospinal Fluid of Nonhuman Primates.

Abstract The present study builds on previous work showing that infusion of adeno-associated virus type 9 (AAV9) into the cisterna magna (CM) of nonhuman primates resulted in widespread transduction t...

Use of fibrin sealant (Tisseel/Tissucol) in hernia repair: a systematic review.

BACKGROUND: Abdominal wall and inguinal hernia repair are the most frequently performed surgical procedures in the United States and Europe. However, traditional methods of mesh...

Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9.

Delivery of therapeutic genes to a large region of the retina with minimal damage from intraocular surgery is a central goal of treatment for retinal degenerations. Recent studies have shown that AAV9...

Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs.

Adeno-associated viral vector 9 (AAV9) has recently been shown to penetrate the blood-brain barrier via intravascular administration, making it a good candidate for diffuse gene delivery. However, the...

AAV9-mediated VEGF-B Gene Transfer Improves Systolic Function in Progressive Left Ventricular Hypertrophy.

Mechanisms of the transition from compensatory hypertrophy to heart failure are poorly understood and the roles of vascular endothelial growth factors (VEGFs) in this process have not been fully clari...