Selective monoamine oxidase type B MAOB inhibitors

The clinical benefit of monoamine oxidase type B (MAO-B) inhibitors is thought to arise from an ability of these medications to enhance the level of dopamine by decreasing the catabolism. Additional...

Bad medicine: co-codamol

bmj;346/mar20_1/f1821/FIG1F1fig1The UK Home Office has recently highlighted the sharp rise in prescribing, misuse, and deaths linked to tramadol.1 We’ve known tramadol as a problem in general......

ACMD recommends reclassifying tramadol

Tramadol should be reclassified as a class C drug and listed in schedule 3 of the Misuse of Drugs Regulations 2001, says the Advisory Council on the Misuse of Drugs in a letter addressed to the Home...

Drug experts call for stronger regulation of tramadol to reduce misuse

The UK government should make the analgesic tramadol a controlled class C substance that carries a potential fine and prison sentence for anyone found using it without a prescription or dealing in......

Cipher, Tecnofarma sign supply agreement for extended-release tramadol

Cipher Pharmaceuticals has entered into a definitive distribution and supply agreement with Tecnofarma International under which Cipher has granted Tecnofarma the exclusive right to market and distrib...

Tramadol needs tighter control

The Advisory Council on the Misuse of Drugs (ACMD) has said that tighter controls should be put on the painkiller tramadol. The UK’s official drugs adviser has raised concerns about an increase...

Quick, simple test developed to identify patients who will not respond to the painkiller tramadol

(ESA (European Society of Anaesthesiology)) French researchers have found a way to identify quickly the five-ten percent of patients in whom the commonly used painkiller, tramadol, does not work effec...

Excipients Top List of Hot Topics at The Bioavailability Challenge

Formulators still think of excipients first when faced with drug bioavailability difficulties judging by trends that emerged at our online event.

Dow Signs Up Cambrex for Bioavailability Partnership

Dow has contracted Cambrex to make its solubility enhancing polymer HPMCAS, adding manufacturing clout to its bioavailability-focused collaboration with Bend Research.

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction.

PURPOSE: We assessed possible drug interactions of tramadol given concomitantly with the potent CYP2B6 inhibitor ticlopidine, alone or together with the potent CYP3A4 and P-glycoprotein inhibitor itra...

Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine.

Surveys and drug surveillance have demonstrated that the abuse liability of tramadol is considerably low in the general population but appears to be higher in opiate addicts, and this difference could...

Tramadol and caffeine produce synergistic interactions on antinociception measured in a formalin model.

Drug combinations have been used in clinical practice for the main purpose of increasing therapeutic effect efficacy. The aim of this study was to determine the antinociceptive effect of tramadol and...

Cutaneous silent period in hand muscles is lengthened by tramadol: Evidence for monoaminergic modulation?

The purpose of this study was to shed light on the neurochemical modulatory mechanisms of the noxious spinal inhibitory cutaneous silent period (CSP). We study the effects of 100mg of oral tramadol in...

Pharmacodynamic profile of tramadol in humans: influence of naltrexone pretreatment.

RATIONALE: Tramadol is a prescription analgesic that activates mu opioid and monoamine receptor systems. Tramadol is thought to have limited abuse potential compared to mu opioid agonists, but laborat...