Pancreatic Cancer

The pancreas secretes a number of important hormones into the digestive tract and the blood stream. Cancers are most commonly exocrine than endocrine (neuroendocrine) tumors. Functional tumors secre...

Selective monoamine oxidase type B MAOB inhibitors

The clinical benefit of monoamine oxidase type B (MAO-B) inhibitors is thought to arise from an ability of these medications to enhance the level of dopamine by decreasing the catabolism. Additional...

Bad medicine: co-codamol

bmj;346/mar20_1/f1821/FIG1F1fig1The UK Home Office has recently highlighted the sharp rise in prescribing, misuse, and deaths linked to tramadol.1 We’ve known tramadol as a problem in general......

ACMD recommends reclassifying tramadol

Tramadol should be reclassified as a class C drug and listed in schedule 3 of the Misuse of Drugs Regulations 2001, says the Advisory Council on the Misuse of Drugs in a letter addressed to the Home...

Drug experts call for stronger regulation of tramadol to reduce misuse

The UK government should make the analgesic tramadol a controlled class C substance that carries a potential fine and prison sentence for anyone found using it without a prescription or dealing in......

Cipher, Tecnofarma sign supply agreement for extended-release tramadol

Cipher Pharmaceuticals has entered into a definitive distribution and supply agreement with Tecnofarma International under which Cipher has granted Tecnofarma the exclusive right to market and distrib...

Ampio planning follow-on

Ampio Pharmaceuticals Inc. (NASDAQ:AMPE) said late Thursday it is planning a follow-on underwritten by Aegis Capital and Fordham Financial Management. Ampio's Zertane, a fast-dissolving tablet formula...

Tablet Design Software

iTab offers tablet manufacturers a unique tablet design software that aids in the design and calculation of key tablet parameters, while also performing stress analysis for round and shape tool tips i...

Ampio adds $16.9 million

Ampio Pharmaceuticals Inc. (NASDAQ:AMPE) raised $16.9 million through the sale of 5.2 million shares at $3.25 in a follow-on, including the exercise of the deal's overallotment. Aegis Capital and Ford...

Tramadol needs tighter control

The Advisory Council on the Misuse of Drugs (ACMD) has said that tighter controls should be put on the painkiller tramadol. The UK’s official drugs adviser has raised concerns about an increase...

Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation.

Premature ejaculation (PE) is the most common sexual disorder. It affects 20%-30% of adult men; the aetiology of this condition has not yet been elucidated. The aim of this study is to evaluate the ef...

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction.

PURPOSE: We assessed possible drug interactions of tramadol given concomitantly with the potent CYP2B6 inhibitor ticlopidine, alone or together with the potent CYP3A4 and P-glycoprotein inhibitor itra...

Tramadol induces conditioned place preference in rats: Interactions with morphine and buprenorphine.

Surveys and drug surveillance have demonstrated that the abuse liability of tramadol is considerably low in the general population but appears to be higher in opiate addicts, and this difference could...

Tramadol and caffeine produce synergistic interactions on antinociception measured in a formalin model.

Drug combinations have been used in clinical practice for the main purpose of increasing therapeutic effect efficacy. The aim of this study was to determine the antinociceptive effect of tramadol and...

Cutaneous silent period in hand muscles is lengthened by tramadol: Evidence for monoaminergic modulation?

The purpose of this study was to shed light on the neurochemical modulatory mechanisms of the noxious spinal inhibitory cutaneous silent period (CSP). We study the effects of 100mg of oral tramadol in...