Transdermal and Intravaginal Steroid Contraceptives

Parathyroid Hormone PTH Receptor

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins. * parathy...

FDA Approves Transdermal Patch for Migraine

The FDA approved a single-use, battery-powered, iontophoretic transdermal system to deliver sumatriptan for the acute treatment of adult migraine with or without aura. FDA Approvals

Noven initiates d-Amphetamine Transdermal System Phase 2 study in ADHD

Noven Pharmaceuticals, Inc., a wholly-owned subsidiary of Hisamitsu Pharmaceutical Co., Inc., today announced commencement of a Phase 2 study of a d-Amphetamine Transdermal System (d-ATS) for the trea...

Japan's Fujifilm To Proceed With Dissolvable Transdermal Patch

Fujifilm said animal tests indicate the efficacy of a transdermal patch that delivers drugs through microneedles made of dissolvable materials.

Tapemark Expands Capabilities for Transdermal Patches

Tapemark has announced the addition of several new capabilities for transdermal patches, including the formulation, blending, and coating steps in the patch manufacturing process.

Medicure develops Aggrastat transdermal delivery formulation

Medicure has developed a transdermal delivery formulation for its AGGRASTAT (tirofiban Hcl) drug for treating acute coronary syndromes.

Noven announces US launch of estradiol transdermal system

Noven Pharmaceutical has announced the US launch of Minivelle (estradiol transdermal system), which contains a plant-based estrogen for treating menopause symptoms including hot flashes and night swea...

AAPS PharmSciTech: The Experimental Evaluation and Molecular Dynamics Simulation of a Heat-Enhanced Transdermal Delivery System

Type: Original PaperTransdermal delivery systems are useful in cases where preferred routes such as the oral route are not available. However, low overall extent of delivery is seen due to the permeat...

SLP to add transdermal, subcutaneous dosing model in GastroPlus

Simulations Plus (SLP) has entered into a collaboration agreement with a pharmaceutical company to add a transdermal and subcutaneous dosing model within its GastroPlus simulation software program.

Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study.

PURPOSE: A novel transdermal formulation of granisetron (the granisetron transdermal delivery system (GTDS)) has been developed to deliver granisetron continuously over 7 days. This double-blind, pha...

Cardiac effects of granisetron in a prospective crossover randomized dose comparison trial.

PURPOSE: Cardiac side effects of granisetron have been studied mostly in adult patients that are using cardiotoxic chemotherapeutics. There is limited evidence in pediatric age g...

Involvement of nitric oxide in granisetron improving effect on scopolamine-induced memory impairment in mice.

Granisetron, a serotonin 5-HT(3) receptor antagonist, widely used as an antiemetic drug following chemotherapy, has been found to improve learning and memory. In this study, effects of granisetron on...

Comparative trial of two intravenous doses of granisetron (1 versus 3 mg) in the prevention of chemotherapy-induced acute emesis: a double-blind, randomized, non-inferiority trial.

PURPOSE: A single 3 mg or 40 μg/kg intravenous dose of granisetron combined with dexamethasone is routinely used in several countries, although the antiemetic guidelines have recommended granisetro...

A meta-analysis of prevention of postoperative nausea and vomiting: randomised controlled trials by Fujii et al. compared with other authors.

The population sampling in randomised controlled trials by Fujii et al. have been shown to exhibit unusual distributions. This systematic review analysed the effectiveness of prophylactic antiemetics...