Search Results for "Trimethoprim Dosing Obese"
Original Source: Trimethoprim/Sulfamethoxazole Pharmacokinetics in Two Patients Undergoing Continuous Venovenous Hemodiafiltration (October).
OBJECTIVE: To determine the extent of elimination of trimethoprim (TMP) and sulfamethoxazole (SMX) via continuous venovenous hemodiafiltration (CVVHDF) in 2 critically ill patients with renal failure. CASE SUMMARY: A 62-year-old woman with Pneumocystis jirovecii pneumonia (PCP) was admitted to our intensive care unit for severe acute respiratory distress syndrome. A 77-year-old man was admitted for aortic root replacement and developed septic shock and nosocomial pneumonia due to Stenotrophomonas maltophili...
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Trimethoprim and Sulfamethoxazole
ATX-MS-1467 for patients with multiple sclerosis (MS)
ATX-MS-1467 is a novel treatment that was developed with the aim of working with the immune system to treat the underlying cause of disease rather than just treating the symptoms or suppressing the...
Interleukin 1 IL 1 Receptor IL 1R
Interleukin-1 (IL-1) beta is a proinflammatory cytokine driving joint inflammation as well as systemic signs of inflammation, such as fever and acute phase protein production. Current therapy targetin...
Therapies targeting TNF have already demonstrated efficacy across a wide range of inflammatory diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondulitis, psoria...
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NIBR and UCSF researchers have shown that altering the dosing regimen of Zelboraf can prevent the development of drug resistance in mouse models of melanoma. The team will now test an intermittent Zel...
Peristaltic Pumps for the Pharmaceutical Industry
Vederflex have provided an award winning pharmaceutical dosing pump for MethaMeasure, helping to deliver a new kind of methadone dosing system. The pump will automate the dosing process, making rehab...
THURSDAY, Oct. 25 (HealthDay News) -- Young, obese males have reduced levels of testosterone, which greatly increases their risk of being impotent and infertile as adults, according to a new study. R...
In Obese Patients With Type 2 Diabetes, Results Of Fitness Program Show Gender Differences
More than one-third of Americans are obese, and these individuals often experience accompanying health issues, such as Type 2 diabetes and cardiovascular problems. In response to the so-called "obesit...
Obese Girls Have Higher Risk Of MS
Although a rare condition, multiple sclerosis (MS) appears to be more common among overweight and obese girls, to the point where extremely obese girls have nearly four times the risk of developing t...
Obese Drivers At Higher Risk Of Death
A new US study finds that obese drivers are much more likely to die in road accidents than drivers of normal weight. The authors say car designers need to make their vehicles safer for obese drivers,...
Study highlights benefits of pharmacy UTI service
Providing trimethoprim to treat urinary tract infections (UTIs) from community pharmacies via a patient group direction (PGD) could improve access for patients and maintain antibiotic stewardship, a...
Acetaminophen dosing guidelines needed for overweight children, report shows
There is considerable discrepancy among caregivers and pharmacists regarding the appropriate dosage of acetaminophen for overweight and obese children.
Matching PubMed Articles
Cefepime Dosing in the Morbidly Obese Patient Population.
Proper dosing of specific antibiotics in morbidly obese patients has been studied inadequately. However, these data are beneficial as this patient population is at an increased risk to develop postope...
The E28D variant of dihydrofolate reductase from Moritella profunda was generated and found to have the same K (i) (within error) for the competitive inhibitor trimethoprim as the...
Colistin dosing and nephrotoxicity in a large community teaching hospital.
Thirty adult patients who received intravenous colistin (5.1 +/- 2.4 mg/kg/day) were reviewed to evaluate dosing with respect to nephrotoxicity, which occurred in 10 (33%) patients within the first 5...
The effects of obesity on drug pharmacokinetics in humans.
Introduction : The prevalence of obesity and associated co-morbid conditions is increasing globally. Physiological changes accompanying obesity are likely to result in altered drug pharmacokinetics; h...
Comparison of initial warfarin response in obese patients versus non-obese patients.
Achieving therapeutic anticoagulation with warfarin is complicated by substantial inter-patient and intra-patient variability with numerous factors known to influence dose requirements. Obesity is one...
