Nerve growth factor NGF

Nerve growth factor (NGF) is the prototypical member of the family of neurotrophin growth factors that are involved in the growth and survival of nervous tissue. NGF and its receptors, the tyrosine-...

Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity

Diamyd Medical divests U.S. gene therapy company

Regulatory News: Diamyd Medical AB has entered into an agreement for the sale of the U.S. subsidiary, Diamyd, Inc., involved in drug development primarily relating...

Phase IIb data scratch the itch for Creabilis

Creabilis has reported positive Phase IIb data from with its lead anti-itch product CT327, a novel topical TrkA kinase inhibitor, in psoriasis patients, although not all study endpoints were met. Cre...

Diamyd Medical Limits Further Investment in the Diabetes Vaccine

Regulatory News: Diamyd Medical AB (STO:DIAMB) has decided to allocate a maximum of SEK 30 million over three years for the development of the diabetes vaccine Dia...

Diamyd Medical Reports Results from Phase II Study in Cancer Pain

Regulatory News: Diamyd Medical AB (STO:DIAMB) (Pink Sheets: DMYDY) reports that a Phase II study evaluating the Company’s drug candidate NP2 Enkephalin did not...

Bulletin from Extraordinary General Meeting of Diamyd Medical AB

Regulatory News: The Extraordinary General Meeting of Diamyd Medical AB (publ)(STO:DIAMB)(Pink Sheets:DMYDY) held today decided in accordance with the Board's reso...

Periphagen Holdings completes management buy-out of [Diamyd Inc.]

Existing management of [Diamyd Inc.] have formed Periphagen Holdings and bought out the US drug delivery division from its parent, Swedish biotech [Diamyd Medical AB]. In return, Diamyd Medical recei...

Summons to Extraordinary General Meeting of Diamyd Medical AB

Regulatory News: The shareholders of Diamyd Medical AB (publ) (STO:DIAMB)(Pink Sheets:DMYDY) are hereby summoned to an Extraordinary General Meeting on Tuesday Oct...

Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells.

The tropomyosin-related kinase A (TrkA) receptor and its ligand, nerve growth factor (NGF), play crucial roles in the development and function of the nervous system. NGF is believed to activate TrkA b...

Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.

Nerve growth factor (NGF) binding to its receptor TrkA, which belongs to the family of receptor tyrosine kinases (RTKs), is known to induce its internalization, endosomal trafficking and subsequent ly...

Heat Shock Protein 90 Inhibition Depletes TrkA Levels and Signaling in Human Acute Leukemia Cells.

Nerve growth factor (NGF) induces autophosphorylation and downstream progrowth and prosurvival signaling from the receptor tyrosine kinase TrkA. Overexpression or activating mutation of TrkA has been...

Colitis elicits differential changes in the expression levels of receptor tyrosine kinase TrkA and TrkB in colonic afferent neurons: A possible involvement of axonal transport.

The role of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in colitis-induced hypersensitivity has been suggested. NGF and BDNF facilitate cellular physiology through binding t...

Absence of nerve growth factor and comparison of tyrosine kinase receptor A levels in mature spermatozoa from oligoasthenozoospermic, asthenozoospermic and fertile men.

BACKGROUND: Nerve growth factor (NGF) and the Tyrosine kinase receptor (TrkA) are expressed in mammalian ovaries and testes, where they are involved in oocyte maturation and spermatogenesis. We assess...