Extrapulmonary Tuberculosis

Tuberculosis Vaccines and Therapeutics

The WHO estimates that the largest number of new tuberculosis (TB) cases in 2008 occurred in the South-East Asia Region, which accounted for 34% of incident cases globally. However, the estimated inci...

Tuberculosis TB

Tuberculosis (TB) is an infectious disease caused by bacteria belonging to the Mycobacterium tuberculosis complex. Over nine million new cases of TB, and nearly two million deaths from TB, are est...

Hepatitis B Immune Globulin Cangene

HepaGam B® [Hepatitis B Immune Globulin (Human) Injection] contains purified antibodies specific for the hepatitis B surface antigen (HBsAg). * It is approved in Canada and the United States f...

Follicle stimulating hormone FSH

Follicle-stimulating hormone (FSH) now has become an established means of ovulation induction (OI) as part of assisted reproductive technology (ART). FSH is used to induce development of multiple foll...

Russian Researchers Develop Highly Accurate TB Test To Replace PPD

Russian scientists say they have developed a new test for tuberculosis they say is nearly 100% accurate, versus the protein purified derivative skin test in use for a the past century.

Interferon-γ-Release Assays for Latent Tuberculosis

To the Editor: The Viewpoint by Drs LoBue and Castro regarding latent tuberculosis infection and the use of interferon-γ-release assays (IGRAs) does not discuss another potential advantage of these b...

[Series] Drug-resistant tuberculosis: time for visionary political leadership

Two decades ago, WHO declared tuberculosis a global emergency, and invested in the highly cost-effective directly observed treatment short-course programme to control the epidemic. At that time, most...

[Comment] Unexpected high levels of multidrug-resistant tuberculosis present new challenges for tuberculosis control

Most international recommendations for tuberculosis control have been developed for multidrug-resistant (MDR) tuberculosis prevalence of up to around 5%. Yet we now face prevalence up to ten times hig...

'Missing link' discovered in the defense mechanism of the tuberculosis pathogen

Flemish biologists lead by Joris Messens (VIB / Vrije Universiteit Brussel) have discovered that Mycobacterium tuberculosis – the bacterium that causes tuberculosis – has an ingenious defence mech...

Tuberculosis pathogen has an ingenious defence mechanism against oxygen

Flemish biologists lead by Joris Messens (VIB / Vrije Universiteit Brussel) have discovered that Mycobacterium tuberculosis - the bacterium that causes tuberculosis - has an ingenious defence mechanis...

[Comment] A major event for new tuberculosis vaccines

One of the great quests of contemporary medical research is the search for an improved tuberculosis vaccine—one that provides greater and more consistent protection against tuberculosis than the BCG...

[Articles] Corticosteroids for prevention of mortality in people with tuberculosis: a systematic review and meta-analysis

Steroids could be effective in reducing mortality for all forms of tuberculosis, including pulmonary tuberculosis. However, further evidence is needed since few recent trials have assessed the effecti...

National shortage of purified-protein derivative tuberculin products.

Tubersol, a product of Sanofi Pasteur Limited, is in short supply nationwide until at least the end of May 2013. Tubersol is one of two purified-protein derivative (PPD) tuberculin products licensed b...

In vitro levels of cytokines in response to purified protein derivative (PPD) antigen in a population with high prevalence of pulmonary tuberculosis.

The control of mycobacterial infection by the host depends on cell-mediated immunity (CMI), involving activated macrophages, T cells, and type 1 cytokines (Th1). Here we evaluated the capacity of anti...

Latent tuberculosis: what the host "sees"?

Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB), is the most successful pathogen of mankind and remains a major threat to global health as the leading cause of death due to...

Eucapsitrione, an Anti-Mycobacterium tuberculosis Anthraquinone Derivative from the Cultured Freshwater Cyanobacterium Eucapsis sp.

Eucapsitrione (1), an anthraquinone derivative with an indeno-anthracene-trione skeleton, was isolated from the cyanobacterium Eucapsis sp. (UTEX 1519) by bioassay-guided fractionation. The chemical s...

Profiling of human leukocyte antigens in Eales disease and tuberculosis.

To analyze the association between Eales disease, histocompatibility leukocyte antigen alleles (HLA-A/B, HLA-DRB/DQB) and tuberculosis infection, and to explore susceptible genes and protective genes...