Heat shock protein Mab rDNA

Heat shock protein 90 Hsp90

Inhibition of heat shock protein 90 (Hsp90) results in the degradation of oncoproteins that drive malignant progression, inducing cell death, making Hsp90 a target of substantial interest for cancer...

Shock

Hemorrhagic shock

Hypovolemic shock

Binding determinants of the small heat shock protein, αB-crystallin: recognition of the ‘IxI’ motif

Binding determinants of the small heat shock protein, αB-crystallin: recognition of the ‘IxI’ motifCytoprotective small heat-shock proteins display an intrinsic affinity for their C-termini in so...

Mutant Heat Shock Protein Vaccine Prevents Vitiligo in Mouse Model

An experimental vaccine based on a genetically modified form of inducible heat shock protein 70 prevented onset and partially...

Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90

The heat shock protein Hsp90 is a potential target for cancer and neurodegeneration drugs. Here, the introduction of a substituent into the 19-position of the naturally occurring inhibitor geldanamyci...

Insight Into Key Protein Linked To Development Of Cancers And Neurodegenerative Disorders

Virginia Commonwealth University researchers studying a key molecular player called Hsp70 that is responsible for protein homeostasis have uncovered how it binds together with another molecule respons...

Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein Inhibits Angiotensin II-Induced Cardiac Remodeling

Heat Biologics files for IPO

Cancer company Heat Biologics Inc. (Miami Beach, Fla.) filed to raise up to $20 million in an IPO underwritten by Aegis Capital. This year, Heat Biologics plans to start Phase II testing of its lead c...

Tubular expression of heat-shock protein 27 inhibits fibrogenesis in obstructive nephropathy

Heat Shock Protein Hsp104 Could Be Developed To Eliminate Toxic Clumps Linked With Neurodegenerative Diseases

Several fatal brain disorders, including Parkinson's disease, are connected by the misfolding of specific proteins into disordered clumps and stable, insoluble fibrils called amyloid. Amyloid fibrils...

The Entamoeba histolytica methylated LINE binding protein EhMLBP provides protection against heat shock.

Adaptation to environmental stress is a key process that allows the unicellular parasite Entamoeba histolytica to survive in its human host. We previously characterized EhMLBP as an essential protein...

Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.

Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown pr...

Heat Shock Proteins Protect Against Ischemia and Inflammation Through Multiple Mechanisms.

After heat shock or other metabolic stress, heat shock proteins (Hsps) are expressed at high levels in all tissues and cells. The highly inducible 70 kDa heat shock protein (Hsp70) is associated with...

Targeting Heat Shock Proteins in Tauopathies.

Heat shock proteins are members of a large family that function normally in nascent protein folding and the removal of damaged proteins and are able to respond to cellular stresses such as thermal ins...

Inhibition of heat shock transcription factor binding by a linear polyamide binding in an unusual 1:1 mode.

Heat shock proteins (HSPs) are known to protect cells from heat, oxidative stress, and the cytotoxic effects of drugs, and thus can enhance cancer cell survival. As a result, HSPs are a newly emerging...