Kinases Raf Inhibitors

The Ras-Raf-MEK-ERK (ERK) pathway is a logical therapeutic target because it represents a common downstream pathway for several key growth factor tyrosine kinase receptors which are often mutated or...

FDA Clears Drug for Urea Cycle Disorders

Glycerol phenylbutyrate has been approved for chronic management of some urea cycle disorders in patients aged 2 years and older. FDA Approvals

Ravicti OK'd for Lethal Urea Cycle Defects

(MedPage Today) -- The Food and Drug Administration has approved glycerol phenylbutyrate (Ravicti) for the treatment of the rare hereditary conditions known as urea cycle disorders.

Hyperion Therapeutics receives FDA approval for Ravicti to treat urea cycle disorders

The U.S. Food and Drug Administration today approved Ravicti (glycerol phenylbutyrate) for the chronic management of some urea cycle disorders (UCDs) in patients ages 2 years and older.

Polycystic kidney disease: An early urea-selective urine-concentrating defect in ADPKD

A defect in urine-concentrating ability is discernable in patients with autosomal dominant polycystic kidney disease (ADPKD) before any decline in glomerular filtration rate, and is associated with el...

A Urea Based Cream for Severe Xerosis in T2DM Patients

Moisturization of foot skin in diabetics is important to prevent diabetic foot complications. This study evaluated the efficacy of a topical urea-based cream compared with a simple emollient. BMC De...

Ravicti approved for urea cycle disorders

(HealthDay)—Ravicti (glycerol phenylbutyrate) has been approved by the U.S. Food and Drug Administration to treat certain urea cycle disorders (UCDs) in people 2 years and older.

FDA approves new drug for the chronic management of some urea cycle disorders

The U.S. Food and Drug Administration today approved Ravicti (glycerol phenylbutyrate) for the chronic management of some urea cycle disorders (UCDs) in patients ages 2 years and older.

FDA Approves Ravicti for the Chronic Management of Some Urea Cycle Disorders

February 1, 2013 -- The U.S. Food and Drug Administration today approved Ravicti (glycerol phenylbutyrate) for the chronic management of some urea cycle disorders (UCDs) in patients ages 2 years and o...

UT-B1 Mediates Transepithelial Urea Flux in the Rat Gastrointestinal Tract.

The process of urea nitrogen salvaging plays a vital role in the symbiotic relationship between mammals and their intestinal bacteria. The first step in this process requires the movement of urea from...

UreA, the major urea/H(+) symporter in Aspergillus nidulans.

We report here the characterization of UreA, a high-affinity urea/H(+) symporter of Aspergillus nidulans. The deletion of the encoding gene abolishes urea transport at low substrate concentrations, su...

Evaporation of Urea at Atmospheric Pressure.

Aqueous urea solution is widely used as reducing agent in the selective catalytic reduction of NO(x) (SCR). Because reports of urea vapor at atmospheric pressure are rare, gaseous urea is usually negl...

How Does the Urea Dynamics Differ from Water Dynamics inside the Reverse Micelle?

In this study, the urea dynamics inside AOT reverse micelle (RM) has been monitored without intervention of water using time-resolved fluorescence techniques from the picosecond to nanosecond time reg...

Geometry-Selective Synthesis of E or Z N-Vinyl Ureas (N-Carbamoyl Enamines).

N-Vinyl ureas are emerging as a valuable class of compounds with both nucleophilic and electrophilic reactivity. They may be made by capturing the enamine tautomer of an imine with an isocyanate, a re...