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GPhA: 'Up-scheduling' hydrocodone combos will impede patient access, won't curb abuse

Ahead of a two-day meeting of the FDA's Drug Safety and Risk Management Advisory Committee (DSaRM), in which regulators are seeking advice about whether to "up-schedule" hydrocodone combination medi...

DEA agent to FDA safety panel: Hydrocodone combos are 'killing us'

Drug safety advisers to the US FDA heard arguments from both ends of the spectrum on 24 January about the impact to patients and society if hydrocodone combination medicines, like Vicodin (acetaminop...

AAPA and AANP Comment on FDA Hydrocodone Recommendation

A recent recommendation by a Food and Drug Administration (FDA) panel about hydrocodone elicited responses from American Association of Nurse Practitioners president Angela Golden, DNP, FNP-C, FAANP,...

FDA panel votes for tougher restrictions on hydrocodone

(HealthDay)—A U.S. Food and Drug Administration advisory panel met Thursday and Friday to discuss the fate of certain painkillers that contain the opioid known as hydrocodone, concluding in a vote i...

FDA panel backs tougher restrictions for hydrocodone products

FDA's Drug Safety and Risk Management Advisory Committee voted 19-10 on Friday that the U.S. Drug Enforcement Administration (DEA) reschedule hydrocodone combination products as class II scheduled dru...

Is Zogenix A Buy After FDA Panel Says 'No' To Zohydro?

ByC.R. Jackson:Zogenix Inc., (ZGNX) is the first pharmaceutical company to face a U.S. Food and Drug Administration (FDA) panel seeking approval for pure hydrocodone, a painkilling drug that can be 10...

FDA Faced With A Judgment Call On Hydrocodone Upscheduling

Commenters in favor of and opposed to new restrictions on combination hydrocodone products make strong cases, but without much new data.

Should Hydrocodone Be Rescheduled?

A pain expert weighs in on an FDA advisory committee's recent vote in favor of reclassifying hydrocodone-containing medications as schedule II. Medscape Neurology

Anomalous observations of hydrocodone in patients on oxycodone.

BACKGROUND: Urine drug monitoring is used by physicians treating chronic pain patients with opioid therapy. Patients are tested in part to insure that they are not taking other drugs. Therefore, the f...

Hydrocodone and morphine possess similar rewarding effects and reduce ERK and CREB phosphorylation in the nucleus accumbens.

The number of prescriptions for hydrocodone-containing opioid analgesics has greatly increased over the past decade. This increase has led to an associated enhancement in the non-medical use of hydroc...

Update on hydrocodone metabolites in rats and dogs aided with a semi-automatic software for metabolite identification Mass-MetaSite.

1. There has been a lack of in vivo metabolite profiling update of hydrocodone since the original report on species differences was published in 1978. As such, the mechanism for its analgesic activity...

Fatal Hydrocodone Overdose in a Child: Pharmacogenetics and Drug Interactions.

Fatal opioid toxicity occurred in a developmentally delayed child aged 5 years 9 months who was inadvertently administered high doses of hydrocodone for a respiratory tract infection. The concentratio...

Propoxyphene and the risk of out-of-hospital death.

PURPOSE: The opioid analgesic propoxyphene was withdrawn from the US market in 2010, motivated by concerns regarding fatality in overdose and adverse cardiac effects, including prolongation of the QT...