Vasodilators

Vasodilation refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles and large veins....

CD30 Antibodies

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. It...

Sub-Saharan Africa

Sub-Saharan Africa is a massive market for biotechnology companies with its collection of tropical diseases, large populations and agricultural importance. It is not only a customer in this industry...

SIRT1, heme oxygenase-1 and NO-mediated vasodilation in a human model of endogenous angiotensin II type 1 receptor antagonism: implications for hypertension

Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model

(University of Pennsylvania School of Medicine) Researchers show how fish oils help lower blood pressure via vasodilation at ion channels. In vascular smooth muscle cells, such as those that line bloo...

Study shows how fish oils help lower blood pressure via vasodilation at ion channels

Omega-3 fatty acids found in oily fish may have diverse health-promoting effects, potentially protecting the immune, nervous, and cardiovascular systems.

Risk Adjustment: K-fold Cross Validation

Oftentimes, researchers will use an existing risk adjustment model and apply it to new data.  The question is, which risk adjustment model should be used?  The most popular method is to calibrate th...

[Comment] Vasodilation out of the picture as a cause of migraine headache

The idea of migraine as a “vascular headache” has endured for decades despite progressively increasing contradictory evidence. Findings from the study by Faisal Amin and colleagues reported in thi...

Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers

A slight mechanical pressure applied to healthy skin results in blood vessel dilation, preserving blood flow. Defects in this vasodilatory response lead to an increased risk of pressure ulcers. Fromy...

Why fish is better than supplements: Omega-3s from fish vs. fish oil pills better at maintaining blood pressure in mouse model

Researchers show how fish oils help lower blood pressure via vasodilation at ion channels. In vascular smooth muscle cells, such as those that line blood vessels, ion channels that span the outer memb...

Activists propose new model to fight HIV/AIDS in Kenya

"Twenty-eight years since the first HIV/AIDS case was reported in Kenya, organizations are proposing a new model to fight the epidemic," Sabahi reports. "The model, called 'SAVE,' an acronym for 'Safe...

A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches.

Non-steroidal anti-inflammatory drugs (NSAIDs) that act as cyclo-oxygenase (COX) inhibitors are commonly used in the treatment of a range of headache disorders, although their mechanism of action is u...

Differential effects on nitric oxide-mediated vasodilation in mesenteric and uterine arteries from cytomegalovirus-infected mice.

Chronic cytomegalovirus (CMV) infections are implicated in vascular diseases. Recently, we showed that an active mouse CMV (mCMV) infection in non-pregnant mice increased endothelial-dependent vasodil...

Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta.

In large vessels, endothelium-dependent vasodilation is mainly attributed to endothelial nitric oxide synthase (eNOS)-derived NO production. However, we have recently shown that neuronal nitric oxide...

Involvement of endothelium-dependent and -independent mechanisms in midazolam-induced vasodilation.

Benzodiazepine (BDZ) infusion has been shown to reduce blood pressure in both humans and animals. Although the inhibitory effects of BDZ on the central nervous system have been well documented, less i...

Enalaprilat-Mediated Activation of Kinin B(1) Receptors and Vasodilation in the Rat Isolated Perfused Kidney.

The present study evaluated whether enalaprilat (the active form of enalapril, an angiotensin-converting enzyme inhibitor) activates B(1) receptors. We observed that the levels of B(1) receptor mRNA a...