Search Results for "Vdr Mechanism Of Action"
Original Source: Mechanism of action of vitamin D and the vitamin D receptor in colorectal cancer prevention and treatment.
Vitamin D and its analogs are potent inhibitors of colorectal cancer growth and metastasis. A number of recent studies have defined the intersections between the β-catenin-TCF pathway (a known contributor to colorectal cancer progression) and the vitamin D receptor (VDR) pathway, shedding light on the underlying mechanisms. Vitamin D also regulates the innate immune response, and as such influences susceptibility to inflammatory bowel disease, a predisposing factor in colorectal cancer. Understanding the r...
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Antibody-drug conjugates are designed to combine the specificity of antibodies directed against tumor-associated targets with potent cytotoxity. Upon internalization of the ADC, the antibody-bound c...
Most hepatitis C virus (HCV) infected individuals seeking treatment are chronically infected. Treatment goal is to achieve a sustained virological response (SVR), which is the absence of serum HCV R...
Tuberculosis Vaccines and Therapeutics
The WHO estimates that the largest number of new tuberculosis (TB) cases in 2008 occurred in the South-East Asia Region, which accounted for 34% of incident cases globally. However, the estimated inci...
Caspases are a family of enzymes with very specific characteristics that can be used in almost every biological pathway in the body. The knock-on effects of the action of caspases keep us alive, ini...
Sphingosine-1-phospate (S1P) is a phospholipid released by platelets, mast and other cells. It is now known that S1P stimulates at least five different G-protein coupled receptors (GPCRs): S1P1, S1P2,...
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Scientists unravel action mechanism of castor oil
Castor oil is known primarily as an effective laxative; however, it was also used in ancient times with pregnant women to induce labour. Only now have scientists at the Max Planck Institute for Heart...
Phase I for Acorda's new mechanism of action in heart failure justifies more studies
Phase I data are sufficient to justify another human clinical trial in the treatment of heart failure with Acorda Therapeutics' glial growth factor 2 (GGF2), which offers a new mechanism of action t...
LONDON, ONTARIO -- (Marketwire) -- 09/20/12 -- Critical Outcome Technologies Inc. (COTI) (TSX VENTURE: COT) announced today new data that broadens the mechanism of action (MOA) of the Company's lea...
NIH study uncovers new mechanism of action for class of chemotherapy drugs
National Institutes of Health (NIH) researchers have discovered a significant new mechanism of action for a class of chemotherapy drugs known as poly (ADP-ribose) polymerase inhibitors, or PARP inhibi...
Study provides novel mechanism of action of anti-cancer compound: perifosine
Aeterna Zentaris Inc. today announced that an article published in the May 2012 issue of Plos One, outlines a novel mechanism of action of the Company's oral anti-cancer compound, perifosine, which co...
Phase I for Acorda's new mechanism of action in heart failure justifies Phase II
Phase I data are sufficient to justify a Phase II clinical trial in the treatment of heart failure with Acorda Therapeutics' glial growth factor 2 (GGF2), which offers a new mechanism of action that...
G protein-coupled receptor mediates the action of castor oil
(Max-Planck-Gesellschaft) Action mechanism of one of the oldest drugs known to man elucidated.
Biochemists trap a chaperone machine in action
(University of Massachusetts at Amherst) Molecular chaperones have emerged as exciting new potential drug targets, because scientists want to learn how to stop cancer cells, for example, from using ch...
Matching PubMed Articles
Roles of Subcellular Na(+) Channel Distributions in the Mechanism of Cardiac Conduction.
The gap junction and voltage-gated Na(+) channel play an important role in the action potential propagation. The purpose of this study was to elucidate the roles of subcellular Na(+) channel distribut...
Receptor ligands might act as agonists, partial agonists, inverse agonists, or antagonists and it is often difficult to understand structural modifications that alter the mechanism of action. In order...
Rhizoma Drynariae (RD) is an effectively traditional Chinese medicine which is usually used in treating osteoporosis, bone fracture, streptomycin ototoxicity and hyperlipemia. Up to now, studies on ph...
